AutismKB 2.0

Annotation Details for NR3C1


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Basic Information Top
Gene Symbol:NR3C1 ( GCCR,GCR,GR,GRL )
Gene Full Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Band: 5q31.3
Quick LinksEntrez ID:2908; OMIM: 138040; Uniprot ID:GCR_HUMAN; ENSEMBL ID: ENSG00000113580; HGNC ID: 7978
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus15769988
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm15769988
GO:0005759TAS-mitochondrial matrix10887960
GO:0005815IEA-microtubule organizing center-
GO:0005819IEA-spindle-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0043234IDA-protein complex26593036
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding16728402
GO:0001047IDA-core promoter binding17081986
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding16728402
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding15769988
GO:0003723IEA-RNA binding-
GO:0004883TAS-glucocorticoid receptor activity8621628
GO:0005496IDA-steroid binding15769988
GO:0005515IPI-protein binding9079630
GO:0008270IEA-zinc ion binding-
GO:0032183IPI-SUMO binding17081986
GO:0038051IDA-glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity17635946
GO:0051879IPI-Hsp90 protein binding26593036
GO:1990239IDA-steroid hormone binding17635946
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter12902338
GO:0006351IDA-transcription, DNA-templated17081986
GO:0006355IDA-regulation of transcription, DNA-templated19141540
GO:0006366TAS-transcription from RNA polymerase II promoter8621628
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006915IEA-apoptotic process-
GO:0007049IEA-cell cycle-
GO:0007059IEA-chromosome segregation-
GO:0007165TAS-signal transduction7769088
GO:0016569IEA-covalent chromatin modification-
GO:0042921IEA-glucocorticoid receptor signaling pathway-
GO:0043402IEA-glucocorticoid mediated signaling pathway-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter15769988
GO:0051301IEA-cell division-
GO:0071383IDA-cellular response to steroid hormone stimulus15769988
GO:0071549IMP-cellular response to dexamethasone stimulus12902338
GO:0071560IDA-cellular response to transforming growth factor beta stimulus12902338
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NR3C1ADA1091659154805 Reconstituted Complex
NR3C1ADA1066149154805 Reconstituted Complex
NR3C1BAG11070499603979 11101523 Reconstituted Complex
NR3C1BAG11091659603979 11101523 Reconstituted Complex
NR3C1CALR1091658107808 Reconstituted Complex
NR3C1CALR1072628107808 Reconstituted Complex
NR3C1CEBPA1091659817600 Reconstituted Complex
NR3C1CEBPA1074799817600 Reconstituted Complex
NR3C1CEBPB1091659817600 Reconstituted Complex; Two-hybrid
NR3C1CEBPB1074809817600 Reconstituted Complex; Two-hybrid
NR3C1CREB11077758449898 Reconstituted Complex
NR3C1CREB11091658449898 Reconstituted Complex
NR3C1CREBBP1077779590696 9649342 Affinity Capture-Western; Reconstituted Complex
NR3C1CREBBP1091659590696 9649342 Affinity Capture-Western; Reconstituted Complex
NR3C1DAXX10798512595526 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR3C1DAXX10916512595526 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR3C1EP30010834717884810 Affinity Capture-Western
NR3C1EP30010916517884810 Affinity Capture-Western
NR3C1NR2F610916510713182 Reconstituted Complex
NR3C1NR2F610837510713182 Reconstituted Complex
NR3C1ETS210916511279115 Affinity Capture-Western
NR3C1ETS210841511279115 Affinity Capture-Western
NR3C1FKBP41091658341706 Reconstituted Complex
NR3C1FKBP41085788341706 Reconstituted Complex
NR3C1SFN10907212730237 Two-hybrid
NR3C1SFN10916512730237 Two-hybrid
RELANR3C11119027659084 8290595 10995388 Affinity Capture-Western; Reconstituted Complex
RELANR3C11091657659084 8290595 10995388 Affinity Capture-Western; Reconstituted Complex
NFKB1NR3C11091657823959 16380507 Affinity Capture-Western; Reconstituted Complex
NFKB1NR3C11108577823959 16380507 Affinity Capture-Western; Reconstituted Complex
NFKB2NR3C11108587823959 Reconstituted Complex
NFKB2NR3C11091657823959 Reconstituted Complex
HSP90AA1NR3C11091658621522 8645634 8898375 9334248 10066374 10903152 12093808 15916966 16087666 Affinity Capture-Western; Co-localization; Reconstituted Complex
HSP90AA1NR3C11095528621522 8645634 8898375 9334248 10066374 10903152 12093808 15916966 16087666 Affinity Capture-Western; Co-localization; Reconstituted Complex
STAT5BNR3C11126548878484 Affinity Capture-Western
STAT5BNR3C11091658878484 Affinity Capture-Western
YWHAHNR3C11091659079630 Reconstituted Complex; Two-hybrid
YWHAHNR3C11133659079630 Reconstituted Complex; Two-hybrid
TRIM24NR3C11143339115274 Reconstituted Complex
TRIM24NR3C11091659115274 Reconstituted Complex
SMARCA4NR3C11124819128241 10688647 12917342 17387179 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
SMARCA4NR3C11091659128241 10688647 12917342 17387179 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
HNRNPUNR3C11094339353307 Affinity Capture-Western
HNRNPUNR3C11091659353307 Affinity Capture-Western
STAT3NR3C11091659388192 14522952 Affinity Capture-Western; Reconstituted Complex
STAT3NR3C11126519388192 14522952 Affinity Capture-Western; Reconstituted Complex
POU1F1NR3C11114459426156 Reconstituted Complex
POU1F1NR3C11091659426156 Reconstituted Complex
POU2F1NR3C11114479584182 10480874 10490647 Affinity Capture-Western; Reconstituted Complex
POU2F1NR3C11091659584182 10480874 10490647 Affinity Capture-Western; Reconstituted Complex
POU2F2NR3C11114489584182 10480874 10490647 Reconstituted Complex
POU2F2NR3C11091659584182 10480874 10490647 Reconstituted Complex
NCOA2NR3C11091659590696 11266503 12151000 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
NCOA2NR3C11157619590696 11266503 12151000 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
NCOA1NR3C11091659590696 10659697 11266503 12118039 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1NR3C11142009590696 10659697 11266503 12118039 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NEDD4LNR3C11169159649342 Reconstituted Complex
NEDD4LNR3C11091659649342 Reconstituted Complex
TADA2ANR3C11127349649342 Reconstituted Complex
TADA2ANR3C11091659649342 Reconstituted Complex
TBPNR3C11091659649342 Reconstituted Complex
TBPNR3C11127719649342 Reconstituted Complex
HMGB1NR3C11091659671457 Reconstituted Complex
HMGB1NR3C11093899671457 Reconstituted Complex
HMGB2NR3C11091659671457 Reconstituted Complex
HMGB2NR3C11093919671457 Reconstituted Complex
TRIM28NR3C11154579742105 Affinity Capture-Western; Reconstituted Complex
TRIM28NR3C11091659742105 Affinity Capture-Western; Reconstituted Complex
TXNNR3C11091659915858 Reconstituted Complex; Two-hybrid
TXNNR3C11131469915858 Reconstituted Complex; Two-hybrid
ECDNR3C11091659928932 Two-hybrid
ECDNR3C11164509928932 Two-hybrid
NRIP1NR3C111384310364267 10659697 11266503 12773562 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NRIP1NR3C110916510364267 10659697 11266503 12773562 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ONECUT1NR3C110941710430878 Reconstituted Complex
ONECUT1NR3C110916510430878 Reconstituted Complex
MED1NR3C111146510508170 11266503 Reconstituted Complex
MED1NR3C110916510508170 11266503 Reconstituted Complex
MED14NR3C110916510508170 Reconstituted Complex; Two-hybrid
MED14NR3C111469910508170 Reconstituted Complex; Two-hybrid
ARPC5NR3C110916510508170 Two-hybrid
ARPC5NR3C111539910508170 Two-hybrid
HSPD1NR3C110956110508170 Two-hybrid
HSPD1NR3C110916510508170 Two-hybrid
RANNR3C111183710508170 Two-hybrid
RANNR3C110916510508170 Two-hybrid
TSG101NR3C111310210508170 Two-hybrid
TSG101NR3C110916510508170 Two-hybrid
NCOA4NR3C111372610517667 Two-hybrid
NCOA4NR3C110916510517667 Two-hybrid
SMAD3NR3C111026310518526 12902338 Affinity Capture-Western; Reconstituted Complex
SMAD3NR3C110916510518526 12902338 Affinity Capture-Western; Reconstituted Complex
NCOA6NR3C111669110567404 Reconstituted Complex
NCOA6NR3C110916510567404 Reconstituted Complex
PTGES3NR3C111595210691735 16087666 Affinity Capture-Western
PTGES3NR3C110916510691735 16087666 Affinity Capture-Western
PPARGC1ANR3C111609710713165 Two-hybrid
PPARGC1ANR3C110916510713165 Two-hybrid
TGFB1I1NR3C110916510848625 Two-hybrid
TGFB1I1NR3C111289910848625 Two-hybrid
DAP3NR3C110916510903152 Far Western; Reconstituted Complex; Two-hybrid
DAP3NR3C111358710903152 Far Western; Reconstituted Complex; Two-hybrid
HDAC2NR3C110931610958685 Affinity Capture-Western
HDAC2NR3C110916510958685 Affinity Capture-Western
RAF1NR3C111183111005817 Affinity Capture-Western
RAF1NR3C110916511005817 Affinity Capture-Western
TP53NR3C110916511080152 11562347 Affinity Capture-Western; Reconstituted Complex
TP53NR3C111301011080152 11562347 Affinity Capture-Western; Reconstituted Complex
PIAS2NR3C110916511117529 Reconstituted Complex
PIAS2NR3C111452311117529 Reconstituted Complex
NR3C2NR3C111045111154266 Reconstituted Complex; Two-hybrid
NR3C2NR3C110916511154266 Reconstituted Complex; Two-hybrid
NCLNR3C111077111162542 Reconstituted Complex
NCLNR3C110916511162542 Reconstituted Complex
NCOA3NR3C111384111266503 12917342 Affinity Capture-Western; Reconstituted Complex
NCOA3NR3C110916511266503 12917342 Affinity Capture-Western; Reconstituted Complex
KDM5ANR3C111186211358960 Reconstituted Complex
KDM5ANR3C110916511358960 Reconstituted Complex
UBCNR3C110916511555652 11562347 12490527 Affinity Capture-Western
UBCNR3C111316411555652 11562347 12490527 Affinity Capture-Western
MDM2NR3C111035811562347 Affinity Capture-Western
MDM2NR3C110916511562347 Affinity Capture-Western
PSMC3IPNR3C110916511739747 Affinity Capture-Western
PSMC3IPNR3C111894511739747 Affinity Capture-Western
SVILNR3C110916511792840 Two-hybrid
SVILNR3C111270711792840 Two-hybrid
NCOR1NR3C110916512011091 12569182 15016838 15870285 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR1NR3C111497312011091 12569182 15016838 15870285 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR2NR3C111497412011091 15870285 Affinity Capture-Western; Two-hybrid
NCOR2NR3C110916512011091 15870285 Affinity Capture-Western; Two-hybrid
HSPA1ANR3C110953512093808 Reconstituted Complex
HSPA1ANR3C110916512093808 Reconstituted Complex
NR3C1NR3C110916512151000 Co-crystal Structure
RANBP9NR3C111535912361945 Affinity Capture-Western; Two-hybrid
RANBP9NR3C110916512361945 Affinity Capture-Western; Two-hybrid
DDX54NR3C110916512466272 Reconstituted Complex
DDX54NR3C112250312466272 Reconstituted Complex
HOXB1NR3C110945112487626 Affinity Capture-Western
HOXB1NR3C110916512487626 Affinity Capture-Western
PBX1NR3C110916512487626 Affinity Capture-Western
PBX1NR3C111112012487626 Affinity Capture-Western
TDGNR3C111285512874288 Reconstituted Complex
TDGNR3C110916512874288 Reconstituted Complex
SMARCC1NR3C111248312917342 Affinity Capture-Western
SMARCC1NR3C110916512917342 Affinity Capture-Western
SMARCE1NR3C111248912917342 Affinity Capture-Western
SMARCE1NR3C110916512917342 Affinity Capture-Western
SMARCD1NR3C111248612917342 Affinity Capture-Western; Reconstituted Complex
SMARCD1NR3C110916512917342 Affinity Capture-Western; Reconstituted Complex
ZBTB16NR3C111349814521715 Reconstituted Complex
ZBTB16NR3C110916514521715 Reconstituted Complex
JUNNR3C110992814522952 Reconstituted Complex
JUNNR3C110916514522952 Reconstituted Complex
NR2F2NR3C110916514739255 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR2F2NR3C111288414739255 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAD9ANR3C111182014966297 Reconstituted Complex
RAD9ANR3C110916514966297 Reconstituted Complex
HDAC1NR3C110931515826950 16762839 Affinity Capture-Western
HDAC1NR3C110916515826950 16762839 Affinity Capture-Western
PTMSNR3C111173016150697 Affinity Capture-Western
PTMSNR3C110916516150697 Affinity Capture-Western
GRIP1NR3C110916516423881 Affinity Capture-Western
GRIP1NR3C111699516423881 Affinity Capture-Western
SRCNR3C111259216423881 Affinity Capture-Western
SRCNR3C110916516423881 Affinity Capture-Western
SMARCA2NR3C111247917043312 Affinity Capture-Western
SMARCA2NR3C110916517043312 Affinity Capture-Western
C1orf103NR3C110916517455211 Reconstituted Complex
C1orf103NR3C112090517455211 Reconstituted Complex
SETNR3C110916518096310 Affinity Capture-Western; Two-hybrid
SETNR3C111231618096310 Affinity Capture-Western; Two-hybrid
SFPQNR3C110916519339282 Affinity Capture-Western
SFPQNR3C111231919339282 Affinity Capture-Western
NR2E3NR3C110916520211142 Two-hybrid
NR2E3NR3C111532020211142 Two-hybrid
RBM14NR3C110916520211142 Two-hybrid
RBM14NR3C111570020211142 Two-hybrid
ZBTB9NR3C112873620211142 Two-hybrid
ZBTB9NR3C110916520211142 Two-hybrid
MAFFNR3C111726420211142 Two-hybrid
MAFFNR3C110916520211142 Two-hybrid
ZBTB20NR3C110916520211142 Two-hybrid
ZBTB20NR3C111757320211142 Two-hybrid
MSX2NR3C111059420211142 Two-hybrid
MSX2NR3C110916520211142 Two-hybrid
PMLNR3C111138420211142 Two-hybrid
PMLNR3C110916520211142 Two-hybrid
RXRBNR3C110916520211142 Two-hybrid
RXRBNR3C111216920211142 Two-hybrid
ZBTB3NR3C112293320211142 Two-hybrid
ZBTB3NR3C110916520211142 Two-hybrid
ZNF496NR3C112429120211142 Two-hybrid
ZNF496NR3C110916520211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
NR3C1rs6195 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
NR3C1rs6190 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95824
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050522-503'