AutismKB 2.0

Annotation Details for PYCARD


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Basic Information Top
Gene Symbol:PYCARD ( ASC,CARD5,MGC10332,TMS,TMS-1,TMS1 )
Gene Full Name: PYD and CARD domain containing
Band: 16p11.2
Quick LinksEntrez ID:29108; OMIM: 606838; Uniprot ID:ASC_HUMAN; ENSEMBL ID: ENSG00000103490; HGNC ID: 16608
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus-
GO:0005634ISS-nucleus-
GO:0005730IDA-nucleolus-
GO:0005737IDA-cytoplasm14730312
GO:0005737NAS-cytoplasm12019269
GO:0005739IDA-mitochondrion14730312
GO:0005783IEA-endoplasmic reticulum-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0008385IDAcolocalizes_withIkappaB kinase complex12486103
GO:0008385TAS-IkappaB kinase complex12656673
GO:0034774TAS-secretory granule lumen-
GO:0035578TAS-azurophil granule lumen-
GO:0072558IDA-NLRP1 inflammasome complex12191486
GO:0072559IDA-NLRP3 inflammasome complex15030775
GO:0097169IDA-AIM2 inflammasome complex19158676
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding24407287
GO:0005138IPI-interleukin-6 receptor binding24407287
GO:0005515IPI-protein binding11786556
GO:0005523IPI-tropomyosin binding24407287
GO:0008656NAS-cysteine-type endopeptidase activator activity involved in apoptotic process12019269
GO:0017024IPI-myosin I binding24407287
GO:0019899IPI-enzyme binding24407287
GO:0032090IPI-Pyrin domain binding15030775
GO:0042802IPI-identical protein binding24630722
GO:0042803IDA-protein homodimerization activity15030775
GO:0070700IPI-BMP receptor binding24407287
GO:0097153IBA-cysteine-type endopeptidase activity involved in apoptotic process-
GO ID Evidence Qualifier GO_term References
GO:0001773IMP-myeloid dendritic cell activation22732093
GO:0002218IDA-activation of innate immune response21575908
GO:0002277ISS-myeloid dendritic cell activation involved in immune response-
GO:0002588ISS-positive regulation of antigen processing and presentation of peptide antigen via MHC class II-
GO:0002821IMP-positive regulation of adaptive immune response22732093
GO:0006915TAS-apoptotic process10567338
GO:0006919NAS-activation of cysteine-type endopeptidase activity involved in apoptotic process12019269
GO:0006954IEA-inflammatory response-
GO:0007165NAS-signal transduction12019269
GO:0010803IMP-regulation of tumor necrosis factor-mediated signaling pathway14730312
GO:0030838ISS-positive regulation of actin filament polymerization-
GO:0031647ISS-regulation of protein stability-
GO:0032088IMP-negative regulation of NF-kappaB transcription factor activity16585594
GO:0032688IMP-negative regulation of interferon-beta production19158675
GO:0032729ISS-positive regulation of interferon-gamma production-
GO:0032755ISS-positive regulation of interleukin-6 production-
GO:0032760IMP-positive regulation of tumor necrosis factor production16982856
GO:0033209IDA-tumor necrosis factor-mediated signaling pathway12656673
GO:0042104ISS-positive regulation of activated T cell proliferation-
GO:0042771IMP-intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator14730312
GO:0043065IDA-positive regulation of apoptotic process12646168
GO:0043124IDA-negative regulation of I-kappaB kinase/NF-kappaB signaling12486103
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process15030775
GO:0043312TAS-neutrophil degranulation-
GO:0044351ISS-macropinocytosis-
GO:0045087IEA-innate immune response-
GO:0046330IMP-positive regulation of JNK cascade21487011
GO:0050718IDA-positive regulation of interleukin-1 beta secretion15030775
GO:0050766ISS-positive regulation of phagocytosis-
GO:0050829IMP-defense response to Gram-negative bacterium16982856
GO:0050870IMP-positive regulation of T cell activation22732093
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity19494289
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity12646168
GO:0051607IDA-defense response to virus21575908
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade21487011
GO:0071222IDA-cellular response to lipopolysaccharide12486103
GO:0071347IDA-cellular response to interleukin-112486103
GO:0071356IDA-cellular response to tumor necrosis factor12486103
GO:0071901IDA-negative regulation of protein serine/threonine kinase activity12486103
GO:0072332IMP-intrinsic apoptotic signaling pathway by p53 class mediator14730312
GO:0090197IMP-positive regulation of chemokine secretion21487011
GO:0090200IDA-positive regulation of release of cytochrome c from mitochondria14730312
GO:2000406ISS-positive regulation of T cell migration-
GO:2000484IMP-positive regulation of interleukin-8 secretion16982856
GO:2000778IMP-positive regulation of interleukin-6 secretion16982856
GO:2001056IDA-positive regulation of cysteine-type endopeptidase activity19158676
GO:2001181IMP-positive regulation of interleukin-10 secretion16982856
GO:2001238IDA-positive regulation of extrinsic apoptotic signaling pathway16964285
GO:2001242IDA-regulation of intrinsic apoptotic signaling pathway14730312
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PYCARDMEFV11037411498534 Affinity Capture-Western; Two-hybrid
PYCARDMEFV11887611498534 Affinity Capture-Western; Two-hybrid
PYCARDPRKAR1A11887616189514 Two-hybrid
PYCARDPRKAR1A11155916189514 Two-hybrid
NLRC4PYCARD12181411374873 Two-hybrid
NLRC4PYCARD11887611374873 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
NLRP3PYCARD18360511786556 PYPAF1 interacts with ASC.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1931465
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000511-2'