AutismKB 2.0

Annotation Details for GRM1


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Basic Information Top
Gene Symbol:GRM1 ( GPRC1A,GRM1A,MGLUR1,MGLUR1A,mGlu1 )
Gene Full Name: glutamate receptor, metabotropic 1
Band: 6q24.3
Quick LinksEntrez ID:2911; OMIM: 604473; Uniprot ID:GRM1_HUMAN; ENSEMBL ID: ENSG00000152822; HGNC ID: 4593
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005886TAS-plasma membrane-
GO:0005887IMP-integral component of plasma membrane24603153
GO:0014069IBA-postsynaptic density-
GO:0030425IEA-dendrite-
GO:0038037IDA-G-protein coupled receptor dimeric complex24603153
GO:0038038IPI-G-protein coupled receptor homodimeric complex10945991
GO:0042734IBA-presynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004930TAS-G-protein coupled receptor activity7476890
GO:0005515IPI-protein binding19084525
GO:0008066IDA-glutamate receptor activity10945991
GO:0008066TAS-glutamate receptor activity7476890
GO:0099583IEA-neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-
GO ID Evidence Qualifier GO_term References
GO:0000186IEA-activation of MAPKK activity-
GO:0000187IEA-activation of MAPK activity-
GO:0007186IDA-G-protein coupled receptor signaling pathway24603153
GO:0007196IBA-adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-
GO:0007216IMP-G-protein coupled glutamate receptor signaling pathway24603153
GO:0007268TAS-chemical synaptic transmission9076744
GO:0007626IEA-locomotory behavior-
GO:0019233IEA-sensory perception of pain-
GO:0038042IDA-dimeric G-protein coupled receptor signaling pathway24603153
GO:0051482IMP-positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway24603153
GO:0051930IEA-regulation of sensory perception of pain-
GO:0051966IBA-regulation of synaptic transmission, glutamatergic-
GO:0071257IEA-cellular response to electrical stimulus-
GO:0099566IEA-regulation of postsynaptic cytosolic calcium ion concentration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRM1ADORA110664611278325 Affinity Capture-Western
GRM1ADORA110916811278325 Affinity Capture-Western
GRM1GRM110916810349865 10945991 Affinity Capture-Western; Reconstituted Complex
TRPC1GRM111307114614461 Affinity Capture-Western
TRPC1GRM110916814614461 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1351338
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7893'