AutismKB 2.0

Annotation Details for TBK1


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Basic Information Top
Gene Symbol:TBK1 ( FLJ11330,NAK,T2K )
Gene Full Name: TANK-binding kinase 1
Band: 12q14.2
Quick LinksEntrez ID:29110; OMIM: 604834; Uniprot ID:TBK1_HUMAN; ENSEMBL ID: ENSG00000183735; HGNC ID: 11584
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm21813773
GO:0005829TAS-cytosol-
GO:0010008TAS-endosome membrane-
GO ID Evidence Qualifier GO_term References
GO:0003676IEA-nucleic acid binding-
GO:0004672TAS-protein kinase activity-
GO:0004674IDA-protein serine/threonine kinase activity25803835
GO:0004674TAS-protein serine/threonine kinase activity21042276
GO:0005515IPI-protein binding14743216
GO:0005524IEA-ATP binding-
GO:0051219IPI-phosphoprotein binding14530355
GO ID Evidence Qualifier GO_term References
GO:0006468IDA-protein phosphorylation27103069
GO:0006954TAS-inflammatory response21042276
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling21042276
GO:0009615TAS-response to virus21042276
GO:0010629IEA-negative regulation of gene expression-
GO:0016239IDA-positive regulation of macroautophagy27103069
GO:0018105IDA-peptidyl-serine phosphorylation25803835
GO:0018107IDA-peptidyl-threonine phosphorylation27103069
GO:0032479TAS-regulation of type I interferon production-
GO:0032480TAS-negative regulation of type I interferon production-
GO:0032481TAS-positive regulation of type I interferon production-
GO:0032606TAS-type I interferon production21042276
GO:0032727IDA-positive regulation of interferon-alpha production16127453
GO:0032728IDA-positive regulation of interferon-beta production16127453
GO:0033138NAS-positive regulation of peptidyl-serine phosphorylation22412986
GO:0035666TAS-TRIF-dependent toll-like receptor signaling pathway-
GO:0043123IEP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0044565IEA-dendritic cell proliferation-
GO:0045087TAS-innate immune response21042276
GO:0045359IEA-positive regulation of interferon-beta biosynthetic process-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16127453
GO:0050830IEA-defense response to Gram-positive bacterium-
GO:0051607IEA-defense response to virus-
GO:1901214NAS-regulation of neuron death25803835
GO:1904417IEA-positive regulation of xenophagy-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TBK1CYLD10792018636086 Affinity Capture-Western
TBK1CYLD11887818636086 Affinity Capture-Western
TBK1HSP90AA210955614743216 Affinity Capture-MS
TBK1HSP90AA211887814743216 Affinity Capture-MS
TBK1IRF310986918636086 Affinity Capture-Western
TBK1IRF311887818636086 Affinity Capture-Western
TBK1NCK11107707706279 Affinity Capture-Western; Reconstituted Complex
TBK1NCK11188787706279 Affinity Capture-Western; Reconstituted Complex
TBK1NFKB111085714743216 Affinity Capture-MS
TBK1NFKB111887814743216 Affinity Capture-MS
TBK1NFKB211085814743216 Affinity Capture-MS
TBK1NFKB211887814743216 Affinity Capture-MS
TBK1PPP6C11152914743216 Affinity Capture-MS
TBK1PPP6C11887814743216 Affinity Capture-MS
TBK1REL11189814743216 Affinity Capture-MS
TBK1REL11887814743216 Affinity Capture-MS
TBK1RELA11190214743216 15489227 Affinity Capture-MS; Biochemical Activity
TBK1RELA11887814743216 15489227 Affinity Capture-MS; Biochemical Activity
TBK1SKP111239114743216 Affinity Capture-MS
TBK1SKP111887814743216 Affinity Capture-MS
TBK1TNF11887815485837 Affinity Capture-MS
TBK1TNF11297915485837 Affinity Capture-MS
TBK1TNFAIP311298319615732 Affinity Capture-MS
TBK1TNFAIP311887819615732 Affinity Capture-MS
TBK1TRAF211303810990461 14743216 20562859 Affinity Capture-MS; Affinity Capture-Western
TBK1TRAF211887810990461 14743216 20562859 Affinity Capture-MS; Affinity Capture-Western
TBK1TRAF311303917991829 Affinity Capture-Western
TBK1TRAF311887817991829 Affinity Capture-Western
TBK1UBC11316418636086 Affinity Capture-Western
TBK1UBC11887818636086 Affinity Capture-Western
TBK1CUL111403214743216 Affinity Capture-MS
TBK1CUL111887814743216 Affinity Capture-MS
TBK1IKBKG11408914743216 20098747 Affinity Capture-MS; Reconstituted Complex
TBK1IKBKG11887814743216 20098747 Affinity Capture-MS; Reconstituted Complex
TBK1BTRC11445714743216 Affinity Capture-MS
TBK1BTRC11887814743216 Affinity Capture-MS
TBK1PPP6R211505314743216 Affinity Capture-MS
TBK1PPP6R211887814743216 Affinity Capture-MS
TBK1TBKBP111510314743216 Affinity Capture-MS
TBK1TBKBP111887814743216 Affinity Capture-MS
TBK1RB1CC111516020562859 Affinity Capture-MS
TBK1RB1CC111887820562859 Affinity Capture-MS
TBK1TANK11532810581243 14743216 17823124 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TBK1TANK11887810581243 14743216 17823124 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TBK1CDC3711631214743216 Affinity Capture-MS
TBK1CDC3711887814743216 Affinity Capture-MS
TBK1PPP6R111653714743216 Affinity Capture-MS
TBK1PPP6R111887814743216 Affinity Capture-MS
TBK1ANKRD2811684714743216 Affinity Capture-MS
TBK1ANKRD2811887814743216 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1929658
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060512-359'