AutismKB 2.0

Annotation Details for UHRF1


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Basic Information Top
Gene Symbol:UHRF1 ( FLJ21925,ICBP90,MGC138707,Np95,RNF106,hNP95 )
Gene Full Name: ubiquitin-like with PHD and ring finger domains 1
Band: 19p13.3
Quick LinksEntrez ID:29128; OMIM: 607990; Uniprot ID:UHRF1_HUMAN; ENSEMBL ID: ENSG00000034063; HGNC ID: 12556
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin17673620
GO:0000790ISS-nuclear chromatin-
GO:0000791IDA-euchromatin21777816
GO:0000792IDA-heterochromatin17967883
GO:0005634IDA-nucleus10646863
GO:0005657IDA-replication fork17673620
GO:0005720IBA-nuclear heterochromatin-
GO:0016363ISS-nuclear matrix-
GO ID Evidence Qualifier GO_term References
GO:0000987IDA-core promoter proximal region sequence-specific DNA binding10646863
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding1868030
GO:0004842IDA-ubiquitin-protein transferase activity17967883
GO:0005515IPI-protein binding15361834
GO:0008270IDA-zinc ion binding21777816
GO:0008327IDA-methyl-CpG binding15361834
GO:0031493ISS-nucleosomal histone binding-
GO:0035064IDA-methylated histone binding17967883
GO:0042393IDA-histone binding21777816
GO:0042802ISS-identical protein binding-
GO:0044729IDA-hemi-methylated DNA-binding17673620
GO:0061630IBA-ubiquitin protein ligase activity-
GO:0061630ISS-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter21777816
GO:0006281IEA-DNA repair-
GO:0006351IEA-transcription, DNA-templated-
GO:0007049IEA-cell cycle-
GO:0008283IEP-cell proliferation15361834
GO:0010216IMP-maintenance of DNA methylation17673620
GO:0010390IBA-histone monoubiquitination-
GO:0010390ISS-histone monoubiquitination-
GO:0016574IDA-histone ubiquitination17967883
GO:0032270IDA-positive regulation of cellular protein metabolic process10646863
GO:0042787IDA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process22945642
GO:0045944IC-positive regulation of transcription from RNA polymerase II promoter10646863
GO:0051865IDA-protein autoubiquitination17967883
GO:0090308IBA-regulation of methylation-dependent chromatin silencing-
GO:2000373IC-positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity10646863
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UHRF1DNMT111889317934516 19800870 19943104 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
UHRF1DNMT110812317934516 19800870 19943104 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
UHRF1DNMT3A11889319798101 Affinity Capture-Western
UHRF1DNMT3A10812519798101 Affinity Capture-Western
UHRF1DNMT3B11889319798101 Affinity Capture-Western
UHRF1DNMT3B10812619798101 Affinity Capture-Western
UHRF1HDAC111889315361834 17934516 19800870 Affinity Capture-Western
UHRF1HDAC110931515361834 17934516 19800870 Affinity Capture-Western
UHRF1HDAC211889315361834 Affinity Capture-Western
UHRF1HDAC210931615361834 Affinity Capture-Western
UHRF1KAT511889319800870 Affinity Capture-Western
UHRF1KAT511577919800870 Affinity Capture-Western
UHRF1EHMT211889319056828 19943104 Affinity Capture-Western; Co-localization
UHRF1EHMT211612319056828 19943104 Affinity Capture-Western; Co-localization
UHRF1BP1UHRF111889315361834 Affinity Capture-MS; Affinity Capture-Western
UHRF1BP1UHRF112023515361834 Affinity Capture-MS; Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
UHRF1D19S216 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1338889
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2039'