AutismKB 2.0

Annotation Details for GRM4


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Basic Information Top
Gene Symbol:GRM4 ( GPRC1D,MGC177594,MGLUR4,mGlu4 )
Gene Full Name: glutamate receptor, metabotropic 4
Band: 6p21.31
Quick LinksEntrez ID:2914; OMIM: 604100; Uniprot ID:GRM4_HUMAN; ENSEMBL ID: ENSG00000124493; HGNC ID: 4596
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IDA-intracellular15102938
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane15102938
GO:0031410IDA-cytoplasmic vesicle15102938
GO:0042734IBA-presynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004930IMP-G-protein coupled receptor activity8738157
GO:0008066IMP-glutamate receptor activity8738157
GO ID Evidence Qualifier GO_term References
GO:0000187IDA-activation of MAPK activity15102938
GO:0007196IMP-adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway15102938
GO:0007268TAS-chemical synaptic transmission8738157
GO:0007269TAS-neurotransmitter secretion15102938
GO:0043410IEP-positive regulation of MAPK cascade15102938
GO:0043523TAS-regulation of neuron apoptotic process15102938
GO:0051966IBA-regulation of synaptic transmission, glutamatergic-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GRM4GRM4_1455T/C, GRM4_2202A/G, GRM4_2890A/G, GRM4_3639C/T, GRM4_IVS5+29CCGGGn, GRM4_Val797Ile, rs1352632, rs1565366, rs16759, rs1906954, rs2228623, rs2229901, rs2499679, rs2499724, rs3756927, rs3778068, rs3798529, rs733457, rs902193, rs937035 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1351341
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018