AutismKB 2.0

Annotation Details for GRM8


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Basic Information Top
Gene Symbol:GRM8 ( FLJ41058,GLUR8,GPRC1H,MGC126724,MGLUR8,mGlu8 )
Gene Full Name: glutamate receptor, metabotropic 8
Band: 7q31.33
Quick LinksEntrez ID:2918; OMIM: 601116; Uniprot ID:GRM8_HUMAN; ENSEMBL ID: ENSG00000179603; HGNC ID: 4600
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane9473604
GO:0042734IBA-presynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004930IMP-G-protein coupled receptor activity9473604
GO:0008066IMP-glutamate receptor activity9473604
GO ID Evidence Qualifier GO_term References
GO:0007196IMP-adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway9473604
GO:0007601TAS-visual perception9473604
GO:0007608IEA-sensory perception of smell-
GO:0030818IDA-negative regulation of cAMP biosynthetic process11166323
GO:0051966IBA-regulation of synaptic transmission, glutamatergic-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GRM8GRM8_C2846T, rs1008907, rs1204520, rs1204579, rs1361963, rs1419391, rs1419441, rs1419460, rs1946109, rs2078760, rs2106149, rs2106189, rs2237748, rs2237765, rs2237797, rs2283066, rs2283088, rs2283094, rs2299472, rs2402851, rs3948648, rs886002, rs978874 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1351345
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018