AutismKB 2.0

Annotation Details for GSK3B


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Basic Information Top
Gene Symbol:GSK3B ( - )
Gene Full Name: glycogen synthase kinase 3 beta
Band: 3q13.33
Quick LinksEntrez ID:2932; OMIM: 605004; Uniprot ID:GSK3B_HUMAN; ENSEMBL ID: ENSG00000082701; HGNC ID: 4617
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus14744935
GO:0005737IDA-cytoplasm14744935
GO:0005739IEA-mitochondrion-
GO:0005813IDA-centrosome21399614
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane20937854
GO:0030877IDA-beta-catenin destruction complex8638126
GO:0030877TAS-beta-catenin destruction complex11955436
GO:0098794IEA-postsynapse-
GO:1990909TAS-Wnt signalosome24115276
GO ID Evidence Qualifier GO_term References
GO:0001085IPI-RNA polymerase II transcription factor binding20864106
GO:0002020IPI-protease binding25118933
GO:0002039IDA-p53 binding14744935
GO:0004672TAS-protein kinase activity22988876
GO:0004674IDA-protein serine/threonine kinase activity8638126
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding8638126
GO:0005524IEA-ATP binding-
GO:0008013IPI-beta-catenin binding8638126
GO:0016301IDA-kinase activity15448698
GO:0016301TAS-kinase activity-
GO:0019901IPI-protein kinase binding18348280
GO:0031625IPI-ubiquitin protein ligase binding21118991
GO:0034236IPI-protein kinase A catalytic subunit binding11035810
GO:0050321IDA-tau-protein kinase activity14690523
GO:0051059IPI-NF-kappaB binding15465828
GO ID Evidence Qualifier GO_term References
GO:0001837IMP-epithelial to mesenchymal transition15448698
GO:0001954IMP-positive regulation of cell-matrix adhesion18156211
GO:0005977IDA-glycogen metabolic process8638126
GO:0006468IDA-protein phosphorylation11035810
GO:0006468TAS-protein phosphorylation26049140
GO:0006983IDA-ER overload response14744935
GO:0007212NAS-dopamine receptor signaling pathway21711983
GO:0007623ISS-circadian rhythm-
GO:0010822IMP-positive regulation of mitochondrion organization25118933
GO:0016055TAS-Wnt signaling pathway-
GO:0018105IDA-peptidyl-serine phosphorylation8638126
GO:0018107IDA-peptidyl-threonine phosphorylation11955436
GO:0021766IMP-hippocampus development19581563
GO:0031333IMP-negative regulation of protein complex assembly16188939
GO:0031334IDA-positive regulation of protein complex assembly8638126
GO:0032091IDA-negative regulation of protein binding16890161
GO:0032092ISS-positive regulation of protein binding-
GO:0032436IC-positive regulation of proteasomal ubiquitin-dependent protein catabolic process11955436
GO:0032886IMP-regulation of microtubule-based process20937854
GO:0035556IDA-intracellular signal transduction14749367
GO:0035556TAS-intracellular signal transduction26049140
GO:0036016ISS-cellular response to interleukin-3-
GO:0043066IDA-negative regulation of apoptotic process14744935
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043547IMP-positive regulation of GTPase activity18156211
GO:0045719TAS-negative regulation of glycogen biosynthetic process19366350
GO:0045732IC-positive regulation of protein catabolic process16188939
GO:0046777IDA-protein autophosphorylation23184662
GO:0046827IDA-positive regulation of protein export from nucleus14744935
GO:0051534IMP-negative regulation of NFAT protein import into nucleus9072970
GO:0060070IC-canonical Wnt signaling pathway9601641
GO:0060070IDA-canonical Wnt signaling pathway18787224
GO:0060070TAS-canonical Wnt signaling pathway26049140
GO:0071109IMP-superior temporal gyrus development19581563
GO:0090090IC-negative regulation of canonical Wnt signaling pathway11955436
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway19366350
GO:0097192ISS-extrinsic apoptotic signaling pathway in absence of ligand-
GO:0099565NAS-chemical synaptic transmission, postsynaptic21711983
GO:1900034TAS-regulation of cellular response to heat-
GO:1900181ISS-negative regulation of protein localization to nucleus-
GO:1901030ISS-positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway-
GO:1901216IDA-positive regulation of neuron death18508033
GO:1904339TAS-negative regulation of dopaminergic neuron differentiation24431302
GO:1904885TAS-beta-catenin destruction complex assembly-
GO:1904886TAS-beta-catenin destruction complex disassembly-
GO:2000077TAS-negative regulation of type B pancreatic cell development19366350
GO:2000466TAS-negative regulation of glycogen (starch) synthase activity19366350
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GSK3BACLY10656317353931 Affinity Capture-MS
GSK3BACLY10918717353931 Affinity Capture-MS
GSK3BAKT110671016009706 Reconstituted Complex
GSK3BAKT110918716009706 Reconstituted Complex
GSK3BAKT210918712434148 Co-crystal Structure
GSK3BAKT210671112434148 Co-crystal Structure
GSK3BAPC10682111251183 Affinity Capture-Western
GSK3BAPC10918711251183 Affinity Capture-Western
GSK3BAR10918715178691 Affinity Capture-Western; Reconstituted Complex
GSK3BAR10686215178691 Affinity Capture-Western; Reconstituted Complex
GSK3BKLF510918720388706 Affinity Capture-Western
GSK3BKLF510715320388706 Affinity Capture-Western
GSK3BCCNE110918714536078 Biochemical Activity
GSK3BCCNE110733814536078 Biochemical Activity
GSK3BCTNNB110788010330181 11251183 11835406 Affinity Capture-Western; Biochemical Activity
GSK3BCTNNB110918710330181 11251183 11835406 Affinity Capture-Western; Biochemical Activity
GSK3BE2F110820118367454 Affinity Capture-Western
GSK3BE2F110918718367454 Affinity Capture-Western
GSK3BEWSR110843117353931 Affinity Capture-MS
GSK3BEWSR110918717353931 Affinity Capture-MS
PRKCAGSK3B1091871324914 Biochemical Activity
PRKCAGSK3B1115641324914 Biochemical Activity
PTPN1GSK3B1091877514173 Biochemical Activity
PTPN1GSK3B1117367514173 Biochemical Activity
DNM1LGSK3B1153709731200 Reconstituted Complex; Two-hybrid
DNM1LGSK3B1091879731200 Reconstituted Complex; Two-hybrid
AXIN1GSK3B1091879734785 12511557 16199882 18632848 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1GSK3B1139099734785 12511557 16199882 18632848 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MUC1GSK3B1091879819408 11152665 Affinity Capture-Western; Reconstituted Complex
MUC1GSK3B1106699819408 11152665 Affinity Capture-Western; Reconstituted Complex
AXIN2GSK3B10918710966653 12183362 Affinity Capture-Western
AXIN2GSK3B11391010966653 12183362 Affinity Capture-Western
NINGSK3B10918711004522 Two-hybrid
NINGSK3B11937211004522 Two-hybrid
NFKB1GSK3B10918711425860 Biochemical Activity
NFKB1GSK3B11085711425860 Biochemical Activity
PTK2GSK3B11171911809746 Affinity Capture-Western
PTK2GSK3B10918711809746 Affinity Capture-Western
GSK3BGSK3B10918711835406 Biochemical Activity
TP53GSK3B10918712048243 Affinity Capture-Western; Phenotypic Enhancement
TP53GSK3B11301012048243 Affinity Capture-Western; Phenotypic Enhancement
SGK3GSK3B10918712054501 Affinity Capture-Western; Two-hybrid
SGK3GSK3B11719512054501 Affinity Capture-Western; Two-hybrid
NOTCH1GSK3B11091312123574 Biochemical Activity; Reconstituted Complex
NOTCH1GSK3B10918712123574 Biochemical Activity; Reconstituted Complex
PPP1CAGSK3B10918712147701 Affinity Capture-Western
PPP1CAGSK3B11149312147701 Affinity Capture-Western
PRKAR2AGSK3B11156212147701 Affinity Capture-Western
PRKAR2AGSK3B10918712147701 Affinity Capture-Western
AKAP11GSK3B11638412147701 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AKAP11GSK3B10918712147701 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ANKRD6GSK3B11654812183362 Affinity Capture-Western
ANKRD6GSK3B10918712183362 Affinity Capture-Western
TSC1GSK3B11309912511557 Affinity Capture-Western
TSC1GSK3B10918712511557 Affinity Capture-Western
TSC2GSK3B11310012511557 16959574 Affinity Capture-Western; Biochemical Activity
TSC2GSK3B10918712511557 16959574 Affinity Capture-Western; Biochemical Activity
NOTCH2GSK3B11091512794074 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NOTCH2GSK3B10918712794074 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MYCGSK3B11069414563837 Affinity Capture-Western
MYCGSK3B10918714563837 Affinity Capture-Western
UPF3AGSK3B10918715231747 Two-hybrid
UPF3AGSK3B12239715231747 Two-hybrid
SNAI1GSK3B11249915448698 15647282 Affinity Capture-Western; Biochemical Activity
SNAI1GSK3B10918715448698 15647282 Affinity Capture-Western; Biochemical Activity
EPM2AGSK3B11367916115820 Affinity Capture-Western; Two-hybrid
EPM2AGSK3B10918716115820 Affinity Capture-Western; Two-hybrid
SNCAIPGSK3B11498616174773 Affinity Capture-Western; Biochemical Activity
SNCAIPGSK3B10918716174773 Affinity Capture-Western; Biochemical Activity
IGF2BP1GSK3B10918717353931 Affinity Capture-MS
IGF2BP1GSK3B11588617353931 Affinity Capture-MS
STRAPGSK3B11634217353931 Affinity Capture-MS
STRAPGSK3B10918717353931 Affinity Capture-MS
DDX20GSK3B11638717353931 Affinity Capture-MS
DDX20GSK3B10918717353931 Affinity Capture-MS
DHX36GSK3B10918717353931 Affinity Capture-MS
DHX36GSK3B12802217353931 Affinity Capture-MS
XPO6GSK3B10918717353931 Affinity Capture-MS
XPO6GSK3B11682117353931 Affinity Capture-MS
SF3B1GSK3B10918717353931 Affinity Capture-MS
SF3B1GSK3B11701717353931 Affinity Capture-MS
GEMIN4GSK3B11910217353931 Affinity Capture-MS
GEMIN4GSK3B10918717353931 Affinity Capture-MS
C14orf129GSK3B11958917353931 Affinity Capture-MS
C14orf129GSK3B10918717353931 Affinity Capture-MS
SMYD2GSK3B10918717353931 Affinity Capture-MS
SMYD2GSK3B12127417353931 Affinity Capture-MS
SMN2GSK3B11249117353931 Affinity Capture-MS
SMN2GSK3B10918717353931 Affinity Capture-MS
SNRNP70GSK3B11250917353931 Affinity Capture-MS
SNRNP70GSK3B10918717353931 Affinity Capture-MS
RPF2GSK3B10918717353931 Affinity Capture-MS
RPF2GSK3B12391717353931 Affinity Capture-MS
PSEN1GSK3B10918717360711 Biochemical Activity
PSEN1GSK3B11164217360711 Biochemical Activity
CIITAGSK3B11041617991736 Biochemical Activity
CIITAGSK3B10918717991736 Biochemical Activity
SMAD3GSK3B10918718172167 Affinity Capture-Western; Reconstituted Complex
SMAD3GSK3B11026318172167 Affinity Capture-Western; Reconstituted Complex
PPARGC1AGSK3B11609718198341 Biochemical Activity
PPARGC1AGSK3B10918718198341 Biochemical Activity
PHLPP1GSK3B11684319797085 Biochemical Activity
PHLPP1GSK3B10918719797085 Biochemical Activity
TRAF2GSK3B10918720562859 Affinity Capture-MS
TRAF2GSK3B11303820562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
GSK3BGSK3B +409G>A, GSK3B -1293C>A, GSK3B -620T>A, GSK3B_1726A>T, GSK3B_Ex10+162T>C, GSK3B_IVS2-68G>A, GSK3B_IVS8+209T>C, rs334558, rs375557, rs6438552 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
GSK3Brs16830689, rs334558, rs6438552 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
GSK3BGSK3B_1727A/T, rs10934502, rs10934503, rs10934505, rs10934506, rs11919783, rs11923196, rs11925868, rs12053912, rs12629015, rs12630592, rs12634889, rs13080945, rs13319151, rs1381841, rs1574154, rs16830720, rs17204365, rs17471, rs1870931, rs2037547, rs2199503, rs2319398, rs2873950, rs3031824, rs334538, rs334543, rs334547, rs334550, rs334555, rs334558, rs334563, rs3755557, rs4072520, rs4340737, rs4388007, rs4491944, rs4624596, rs4688043, rs4688046, rs4688054, rs4688059, rs6438552, rs6772172, rs6779828, rs6797689, rs6805251, rs6808874, rs749768, rs7624540, rs7639388, rs9846422, rs9861883, rs9872302, rs9878473 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1861437
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990714-4'