AutismKB 2.0

Annotation Details for GSN


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Basic Information Top
Gene Symbol:GSN ( DKFZp313L0718 )
Gene Full Name: gelsolin
Band: 9q33.2
Quick LinksEntrez ID:2934; OMIM: 137350; Uniprot ID:GELS_HUMAN; ENSEMBL ID: ENSG00000148180; HGNC ID: 4620
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IEA-ruffle-
GO:0002102IDA-podosome24236012
GO:0005576IDA-extracellular region3020431
GO:0005576ISS-extracellular region-
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space14596804
GO:0005634IDAcolocalizes_withnucleus23729654
GO:0005737IDA-cytoplasm23575248
GO:0005829IDA-cytosol3020431
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane23575248
GO:0005925IDA-focal adhesion21423176
GO:0015629TAS-actin cytoskeleton1321812
GO:0016528IDA-sarcoplasm19549824
GO:0030027IEA-lamellipodium-
GO:0030478IDA-actin cap23575248
GO:0030864IDA-cortical actin cytoskeleton24236012
GO:0030864IDAcolocalizes_withcortical actin cytoskeleton23575248
GO:0034774TAS-secretory granule lumen-
GO:0043209IEA-myelin sheath-
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO:0072562IDA-blood microparticle22516433
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0003779IDA-actin binding18266911
GO:0005509IMP-calcium ion binding14596804
GO:0005515IPI-protein binding10793131
GO:0019904IPI-protein domain specific binding23729654
GO:0045159IPI-myosin II binding23325791
GO:0051015IEA-actin filament binding-
GO ID Evidence Qualifier GO_term References
GO:0006911ISS-phagocytosis, engulfment-
GO:0007568IEA-aging-
GO:0010628IMP-positive regulation of gene expression22952982
GO:0014003IEA-oligodendrocyte development-
GO:0014891IMP-striated muscle atrophy19549824
GO:0022617IMPNOTextracellular matrix disassembly24236012
GO:0030041IDA-actin filament polymerization3020431
GO:0030041IMP-actin filament polymerization23729654
GO:0030041ISS-actin filament polymerization-
GO:0031648IMP-protein destabilization19549824
GO:0042246IEA-tissue regeneration-
GO:0042989IMP-sequestering of actin monomers19666531
GO:0043312TAS-neutrophil degranulation-
GO:0044267TAS-cellular protein metabolic process-
GO:0045010IEA-actin nucleation-
GO:0045471IEA-response to ethanol-
GO:0046597IMP-negative regulation of viral entry into host cell23575248
GO:0048015IEA-phosphatidylinositol-mediated signaling-
GO:0051014IDA-actin filament severing3020431
GO:0051014IMP-actin filament severing23575248
GO:0051014ISS-actin filament severing-
GO:0051016IEA-barbed-end actin filament capping-
GO:0051127IMP-positive regulation of actin nucleation19666531
GO:0051593IEA-response to folic acid-
GO:0051693IMP-actin filament capping19666531
GO:0051693ISS-actin filament capping-
GO:0060271IMP-cilium assembly20393563
GO:0071276IEA-cellular response to cadmium ion-
GO:0071801IMP-regulation of podosome assembly24236012
GO:0090527IGI-actin filament reorganization23575248
GO:0097017IMP-renal protein absorption24601799
GO:0097284IMP-hepatocyte apoptotic process22952982
GO:1902174IMP-positive regulation of keratinocyte apoptotic process23729654
GO:1903689IGI-regulation of wound healing, spreading of epidermal cells23729654
GO:1903689IMP-regulation of wound healing, spreading of epidermal cells23729654
GO:1903903IMP-regulation of establishment of T cell polarity23575248
GO:1903906IMP-regulation of plasma membrane raft polarization23575248
GO:1903909IMP-regulation of receptor clustering23575248
GO:1903923ISS-positive regulation of protein processing in phagocytic vesicle-
GO:1990000IMP-amyloid fibril formation19904968
GO:2001269IMP-positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway22952982
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GSNACTA110918910583954 Co-crystal Structure
GSNACTA110657310583954 Co-crystal Structure
GSNACTN410659611733011 Reconstituted Complex
GSNACTN410918911733011 Reconstituted Complex
GSNAPP10684810329371 Affinity Capture-Western; Reconstituted Complex
GSNAPP10918910329371 Affinity Capture-Western; Reconstituted Complex
GSNAR10918912941811 Reconstituted Complex; Two-hybrid
GSNAR10686212941811 Reconstituted Complex; Two-hybrid
GSNCASP410918917353931 Affinity Capture-MS
GSNCASP410728717353931 Affinity Capture-MS
GSNPTK2B10918912578912 Affinity Capture-Western; Biochemical Activity; Two-hybrid
GSNPTK2B10848012578912 Affinity Capture-Western; Biochemical Activity; Two-hybrid
GSNFN11091896092370 Reconstituted Complex
GSNFN11086216092370 Reconstituted Complex
PLCG1GSN1091899164868 Reconstituted Complex
PLCG1GSN1113519164868 Reconstituted Complex
VDAC1GSN10918911039896 Affinity Capture-Western
VDAC1GSN11325911039896 Affinity Capture-Western
PIK3CAGSN10918911577104 Affinity Capture-Western
PIK3CAGSN11130811577104 Affinity Capture-Western
PTK2GSN10918911577104 Affinity Capture-Western
PTK2GSN11171911577104 Affinity Capture-Western
PTPN12GSN10918911577104 Affinity Capture-Western
PTPN12GSN11174611577104 Affinity Capture-Western
PXNGSN10918911577104 Affinity Capture-Western
PXNGSN11178711577104 Affinity Capture-Western
SRCGSN10918911577104 Affinity Capture-Western
SRCGSN11259211577104 Affinity Capture-Western
VCLGSN10918911577104 Affinity Capture-Western
VCLGSN11325711577104 Affinity Capture-Western
PSMD4GSN10918912601813 Affinity Capture-MS
PSMD4GSN11168312601813 Affinity Capture-MS
STK39GSN10918914563843 Two-hybrid
STK39GSN11815914563843 Two-hybrid
TOM1L1GSN10918916169070 Two-hybrid
TOM1L1GSN11535216169070 Two-hybrid
PPM1BGSN10918917353931 Affinity Capture-MS
PPM1BGSN11149017353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GSNrs306761, rs306770, rs306781 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95851
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-8567'