AutismKB 2.0

Annotation Details for GSTP1


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Basic Information Top
Gene Symbol:GSTP1 ( DFN7,FAEES3,GST3,GSTP,PI )
Gene Full Name: glutathione S-transferase pi 1
Band: 11q13.2
Quick LinksEntrez ID:2950; OMIM: 134660; Uniprot ID:GSTP1_HUMAN; ENSEMBL ID: ENSG00000084207; HGNC ID: 4638
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space22664934
GO:0005622IDA-intracellular18962899
GO:0005634IEA-nucleus-
GO:0005737TAS-cytoplasm16130169
GO:0005739IDA-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO:0031982IDA-vesicle19190083
GO:0034774TAS-secretory granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO:0097057IDA-TRAF2-GSTP1 complex16636664
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004364IDA-glutathione transferase activity1540159
GO:0004364TAS-glutathione transferase activity-
GO:0004602IDA-glutathione peroxidase activity16624487
GO:0005515IPI-protein binding16636664
GO:0008144IEA-drug binding-
GO:0008432ISS-JUN kinase binding-
GO:0019207ISS-kinase regulator activity-
GO:0035730IDA-S-nitrosoglutathione binding11533048
GO:0035731IDA-dinitrosyl-iron complex binding11533048
GO:0043295IEA-glutathione binding-
GO:0070026NAS-nitric oxide binding11533048
GO ID Evidence Qualifier GO_term References
GO:0000302ISS-response to reactive oxygen species-
GO:0002674NAS-negative regulation of acute inflammatory response18962899
GO:0006469IDA-negative regulation of protein kinase activity16636664
GO:0006749IDA-glutathione metabolic process1540159
GO:0006805IDA-xenobiotic metabolic process1540159
GO:0007417TAS-central nervous system development9802272
GO:0009890IDA-negative regulation of biosynthetic process18962899
GO:0010804IC-negative regulation of tumor necrosis factor-mediated signaling pathway16636664
GO:0014003IEA-oligodendrocyte development-
GO:0031100IEA-animal organ regeneration-
GO:0032355IEA-response to estradiol-
GO:0032691IDA-negative regulation of interleukin-1 beta production18962899
GO:0032720IDA-negative regulation of tumor necrosis factor production18962899
GO:0032869IEA-cellular response to insulin stimulus-
GO:0032872ISS-regulation of stress-activated MAPK cascade-
GO:0032873ISS-negative regulation of stress-activated MAPK cascade-
GO:0032930ISS-positive regulation of superoxide anion generation-
GO:0033591IEA-response to L-ascorbic acid-
GO:0034599TAS-cellular response to oxidative stress-
GO:0035726ISS-common myeloid progenitor cell proliferation-
GO:0035732NAS-nitric oxide storage12871931
GO:0043066TAS-negative regulation of apoptotic process16130169
GO:0043124ISS-negative regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043200IEA-response to amino acid-
GO:0043312TAS-neutrophil degranulation-
GO:0043407IDA-negative regulation of MAP kinase activity11408560
GO:0043409NAS-negative regulation of MAPK cascade18962899
GO:0043508IDA-negative regulation of JUN kinase activity16636664
GO:0043651IDA-linoleic acid metabolic process16624487
GO:0045471IEA-response to ethanol-
GO:0048147ISS-negative regulation of fibroblast proliferation-
GO:0051771IDA-negative regulation of nitric-oxide synthase biosynthetic process18962899
GO:0070372ISS-regulation of ERK1 and ERK2 cascade-
GO:0070373IDA-negative regulation of ERK1 and ERK2 cascade11408560
GO:0070664ISS-negative regulation of leukocyte proliferation-
GO:0071222ISS-cellular response to lipopolysaccharide-
GO:0071364IEA-cellular response to epidermal growth factor stimulus-
GO:0071385IEA-cellular response to glucocorticoid stimulus-
GO:0071460IEA-cellular response to cell-matrix adhesion-
GO:0071638IDA-negative regulation of monocyte chemotactic protein-1 production18962899
GO:0071672IEA-negative regulation of smooth muscle cell chemotaxis-
GO:0098869IEA-cellular oxidant detoxification-
GO:1901687TAS-glutathione derivative biosynthetic process-
GO:1904706IEA-negative regulation of vascular smooth muscle cell proliferation-
GO:2001237IDA-negative regulation of extrinsic apoptotic signaling pathway16636664
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GSTP1FANCC10920511433346 14499622 Affinity Capture-Western; Two-hybrid
GSTP1FANCC10847311433346 14499622 Affinity Capture-Western; Two-hybrid
GSTP1GSTP11092059398518 Co-crystal Structure
TGM2GSTP11092059973324 Affinity Capture-Western
TGM2GSTP11129109973324 Affinity Capture-Western
MAPK8GSTP110920511279197 Affinity Capture-Western; Reconstituted Complex
MAPK8GSTP111158511279197 Affinity Capture-Western; Reconstituted Complex
PNO1GSTP112123216169070 Two-hybrid
PNO1GSTP110920516169070 Two-hybrid
PTNGSTP110920516169070 Two-hybrid
PTNGSTP111173116169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
GSTP1rs1138272, rs1695, rs4891 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
GSTP1rs1138272, rs1695, rs1871042, rs612020 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
GSTP1rs1695 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95865
  • Data Attributes: MGI curated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020806-4'