AutismKB 2.0

Annotation Details for MSH6


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Basic Information Top
Gene Symbol:MSH6 ( GTBP,HNPCC5,HSAP )
Gene Full Name: mutS homolog 6 (E. coli)
Band: 2p16.3
Quick LinksEntrez ID:2956; OMIM: 600678; Uniprot ID:MSH6_HUMAN; ENSEMBL ID: ENSG00000116062; HGNC ID: 7329
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IEA-nuclear chromatin-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005794IDA-Golgi apparatus-
GO:0005829IDA-cytosol-
GO:0032301IDA-MutSalpha complex8942985
GO:0043231IDA-intracellular membrane-bounded organelle-
GO ID Evidence Qualifier GO_term References
GO:0000287IDAcontributes_tomagnesium ion binding16403449
GO:0000400IDAcontributes_tofour-way junction DNA binding12034830
GO:0003682IEA-chromatin binding-
GO:0003690IDAcontributes_todouble-stranded DNA binding11809883
GO:0005515IPI-protein binding8942985
GO:0005515IPIcontributes_toprotein binding16403449
GO:0005524IDAcontributes_toATP binding15105434
GO:0016887IDAcontributes_toATPase activity16403449
GO:0030983IDA-mismatched DNA binding23622243
GO:0030983IDAcontributes_tomismatched DNA binding8942985
GO:0032137IDAcontributes_toguanine/thymine mispair binding8942985
GO:0032142IDAcontributes_tosingle guanine insertion binding8942985
GO:0032143IDAcontributes_tosingle thymine insertion binding8942985
GO:0032357IDAcontributes_tooxidized purine DNA binding11756455
GO:0032405IDAcontributes_toMutLalpha complex binding16403449
GO:0035064IDA-methylated histone binding23622243
GO:0042803IPINOTprotein homodimerization activity8942985
GO:0043531IDAcontributes_toADP binding15105434
GO ID Evidence Qualifier GO_term References
GO:0000710ISS-meiotic mismatch repair-
GO:0006281IDA-DNA repair8942985
GO:0006298IDA-mismatch repair10871409
GO:0006298IGI-mismatch repair23603115
GO:0006298IMP-mismatch repair8782829
GO:0006298TAS-mismatch repair-
GO:0008340ISS-determination of adult lifespan-
GO:0008630ISS-intrinsic apoptotic signaling pathway in response to DNA damage-
GO:0009411ISS-response to UV-
GO:0016032IEA-viral process-
GO:0016446ISS-somatic hypermutation of immunoglobulin genes-
GO:0016447ISS-somatic recombination of immunoglobulin gene segments-
GO:0043570IMPNOTmaintenance of DNA repeat elements16388310
GO:0045190ISS-isotype switching-
GO:0045830IEA-positive regulation of isotype switching-
GO:0045910IDA-negative regulation of DNA recombination17715146
GO:0051096IDA-positive regulation of helicase activity17715146
GO:0097193ISS-intrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MSH6AIRE10921120085707 Affinity Capture-MS
MSH6AIRE10682320085707 Affinity Capture-MS
MSH6ATM10921110783165 Co-purification
MSH6ATM10696210783165 Co-purification
MSH6ATR10921120029092 Affinity Capture-Western
MSH6ATR10702720029092 Affinity Capture-Western
MSH6BARD110921111498787 Reconstituted Complex
MSH6BARD110705611498787 Reconstituted Complex
MSH6BLM10921110783165 Co-purification
MSH6BLM10711010783165 Co-purification
MSH6BRCA110921110783165 11498787 16260778 Affinity Capture-MS; Co-purification; Reconstituted Complex; Two-hybrid
MSH6BRCA110714010783165 11498787 16260778 Affinity Capture-MS; Co-purification; Reconstituted Complex; Two-hybrid
MSH6CASP410921117353931 Affinity Capture-MS
MSH6CASP410728717353931 Affinity Capture-MS
MSH6CHEK110921120029092 Affinity Capture-Western
MSH6CHEK110753620029092 Affinity Capture-Western
MSH6ESR110921116260778 Affinity Capture-MS
MSH6ESR110840316260778 Affinity Capture-MS
MSH2MSH61105738942985 9774676 10029069 10783165 14657349 Affinity Capture-MS; Co-purification; Reconstituted Complex
MSH2MSH61092118942985 9774676 10029069 10783165 14657349 Affinity Capture-MS; Co-purification; Reconstituted Complex
RAD50MSH610921110783165 Co-purification
RAD50MSH611541710783165 Co-purification
MLH1MSH610921110783165 Co-purification
MLH1MSH611043810783165 Co-purification
MRE11AMSH610921110783165 Co-purification
MRE11AMSH611050110783165 Co-purification
NBNMSH610921110783165 Co-purification
NBNMSH611076310783165 Co-purification
RFC1MSH610921110783165 Co-purification
RFC1MSH611191310783165 Co-purification
PCNAMSH610921111005803 11274057 12171929 Affinity Capture-MS; Affinity Capture-Western; Far Western; Protein-peptide
PCNAMSH611114211005803 11274057 12171929 Affinity Capture-MS; Affinity Capture-Western; Far Western; Protein-peptide
SMC1AMSH610921114657349 Reconstituted Complex
SMC1AMSH611387114657349 Reconstituted Complex
PRKCZMSH611157615808853 Affinity Capture-Western
PRKCZMSH610921115808853 Affinity Capture-Western
UBCMSH610921115808853 Affinity Capture-Western
UBCMSH611316415808853 Affinity Capture-Western
PMS2MSH610921117148452 Affinity Capture-MS
PMS2MSH611140417148452 Affinity Capture-MS
MYCMSH610921117353931 Affinity Capture-MS
MYCMSH611069417353931 Affinity Capture-MS
TOPBP1MSH611625620029092 Affinity Capture-Western
TOPBP1MSH610921120029092 Affinity Capture-Western
CLSPNMSH610921120029092 Affinity Capture-Western
CLSPNMSH612201520029092 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1343961
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020905-3'