AutismKB 2.0

Annotation Details for ANXA2


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Basic Information Top
Gene Symbol:ANXA2 ( ANX2,ANX2L4,CAL1H,LIP2,LPC2,LPC2D,P36,PAP-IV )
Gene Full Name: annexin A2
Band: 15q22.2
Quick LinksEntrez ID:302; OMIM: 151740; Uniprot ID:ANXA2_HUMAN; ENSEMBL ID: ENSG00000182718; HGNC ID: 537
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IEA-ruffle-
GO:0005576TAS-extracellular region-
GO:0005604IEA-basement membrane-
GO:0005615IDA-extracellular space22664934
GO:0005634IDA-nucleus21630459
GO:0005737IDA-cytoplasm25139904
GO:0005765IDA-lysosomal membrane23360953
GO:0005768IDA-endosome18767904
GO:0005769IEA-early endosome-
GO:0005811IDA-lipid particle14741744
GO:0005829IEA-cytosol-
GO:0005886IDA-plasma membrane18799458
GO:0005913IDA-cell-cell adherens junction25468996
GO:0005938IEA-cell cortex-
GO:0009986IDA-cell surface10809787
GO:0016020IDA-membrane19946888
GO:0016323ISS-basolateral plasma membrane-
GO:0019897IEA-extrinsic component of plasma membrane-
GO:0030496IDA-midbody15166316
GO:0031012ISScolocalizes_withextracellular matrix22261194
GO:0031902IDA-late endosome membrane23360953
GO:0031982IDA-vesicle19190083
GO:0035578TAS-azurophil granule lumen-
GO:0035749IEA-myelin sheath adaxonal region-
GO:0042383IEA-sarcolemma-
GO:0042470IEA-melanosome-
GO:0043220IEA-Schmidt-Lanterman incisure-
GO:0044354IEA-macropinosome-
GO:0045121IDAcolocalizes_withmembrane raft14699089
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO:1990667IDA-PCSK9-AnxA2 complex22848640
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding22848640
GO:0003723IDA-RNA binding22658674
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding14522961
GO:0005544IDA-calcium-dependent phospholipid binding2138016
GO:0005546IMP-phosphatidylinositol-4,5-bisphosphate binding23861394
GO:0008092IEA-cytoskeletal protein binding-
GO:0017137IEA-Rab GTPase binding-
GO:0019834IDA-phospholipase A2 inhibitor activity3013422
GO:0030546IDAcontributes_toreceptor activator activity22848640
GO:0042802IPI-identical protein binding18799458
GO:0044548IPI-S100 protein binding14699089
GO:0048306IPI-calcium-dependent protein binding15226301
GO:0098641IDA-cadherin binding involved in cell-cell adhesion25468996
GO ID Evidence Qualifier GO_term References
GO:0001525IEP-angiogenesis11866539
GO:0001765IMP-membrane raft assembly23861394
GO:0001921IDA-positive regulation of receptor recycling22848640
GO:0001934IEA-positive regulation of protein phosphorylation-
GO:0006900IMP-membrane budding23861394
GO:0007589IEA-body fluid secretion-
GO:0030199IEA-collagen fibril organization-
GO:0031340IDA-positive regulation of vesicle fusion2138016
GO:0032804IDA-negative regulation of low-density lipoprotein particle receptor catabolic process22848640
GO:0036035IDA-osteoclast development7961821
GO:0042730IEA-fibrinolysis-
GO:0043086IEA-negative regulation of catalytic activity-
GO:0043312TAS-neutrophil degranulation-
GO:0044090IMP-positive regulation of vacuole organization25139904
GO:0044147IMP-negative regulation of development of symbiont involved in interaction with host26812398
GO:0048146IEA-positive regulation of fibroblast proliferation-
GO:0051290IDA-protein heterotetramerization23091277
GO:0052362IMP-catabolism by host of symbiont protein26812398
GO:0052405IMP-negative regulation by host of symbiont molecular function26812398
GO:0072661IEA-protein targeting to plasma membrane-
GO:0097066IEA-response to thyroid hormone-
GO:0098609IEA-cell-cell adhesion-
GO:1905581IDA-positive regulation of low-density lipoprotein particle clearance22848640
GO:1905597IDA-positive regulation of low-density lipoprotein particle receptor binding22848640
GO:1905599IMP-positive regulation of low-density lipoprotein receptor activity22848640
GO:1905602IDA-positive regulation of receptor-mediated endocytosis involved in cholesterol transport22848640
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRB2ANXA21091427510700 Affinity Capture-Western
GRB2ANXA21067997510700 Affinity Capture-Western
SOS1ANXA21125377510700 Reconstituted Complex
SOS1ANXA21067997510700 Reconstituted Complex
S100A10ANXA21121899886297 18434302 Affinity Capture-Western; Co-crystal Structure
S100A10ANXA21067999886297 18434302 Affinity Capture-Western; Co-crystal Structure
CTSBANXA210788810777578 Reconstituted Complex
CTSBANXA210679910777578 Reconstituted Complex
APOHANXA210684710809787 Reconstituted Complex
APOHANXA210679910809787 Reconstituted Complex
PCNAANXA211114212171929 Affinity Capture-MS; Affinity Capture-Western
PCNAANXA210679912171929 Affinity Capture-MS; Affinity Capture-Western
PLATANXA210679912468550 Reconstituted Complex
PLATANXA211134312468550 Reconstituted Complex
PHBANXA211126412628297 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PHBANXA210679912628297 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRPV5ANXA212113712660155 Reconstituted Complex
TRPV5ANXA210679912660155 Reconstituted Complex
CEACAM1ANXA210710314522961 Affinity Capture-MS; Reconstituted Complex
CEACAM1ANXA210679914522961 Affinity Capture-MS; Reconstituted Complex
MGMTANXA211041116226712 Affinity Capture-MS
MGMTANXA210679916226712 Affinity Capture-MS
PPM1BANXA211149017353931 Affinity Capture-MS
PPM1BANXA210679917353931 Affinity Capture-MS
STAT6ANXA211265520121258 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
STAT6ANXA210679920121258 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88246
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-1089'