Annotation Details for HCK
Basic Information Top
Gene Symbol: | HCK ( JTK9 ) |
---|---|
Gene Full Name: | hemopoietic cell kinase |
Band: | 20q11.21 |
Quick Links | Entrez ID:3055; OMIM: 142370; Uniprot ID:HCK_HUMAN; ENSEMBL ID: ENSG00000101336; HGNC ID: 4840 |
Relate to Another Database: | SFARIGene; denovo-db |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0005654 | IDA | - | nucleoplasm | - |
GO:0005764 | IDA | - | lysosome | 15998323 |
GO:0005794 | IEA | - | Golgi apparatus | - |
GO:0005829 | TAS | - | cytosol | - |
GO:0005884 | IDA | colocalizes_with | actin filament | 15998323 |
GO:0005886 | IDA | - | plasma membrane | - |
GO:0005901 | IDA | - | caveola | 7791757 |
GO:0005925 | IMP | - | focal adhesion | 11904303 |
GO:0030133 | IEA | - | transport vesicle | - |
GO:0031234 | IMP | - | extrinsic component of cytoplasmic side of plasma membrane | 11904303 |
GO:0042995 | IEA | - | cell projection | - |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0001784 | IPI | - | phosphotyrosine residue binding | 20624904 |
GO:0004713 | EXP | - | protein tyrosine kinase activity | 10861086 |
GO:0004713 | IMP | - | protein tyrosine kinase activity | 10092522 |
GO:0004715 | IBA | - | non-membrane spanning protein tyrosine kinase activity | - |
GO:0005102 | IBA | - | receptor binding | - |
GO:0005515 | IPI | - | protein binding | 7859737 |
GO:0005524 | IEA | - | ATP binding | - |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0002522 | TAS | - | leukocyte migration involved in immune response | 18538446 |
GO:0002758 | TAS | - | innate immune response-activating signal transduction | 18538446 |
GO:0006468 | TAS | - | protein phosphorylation | 3496523 |
GO:0006954 | IEA | - | inflammatory response | - |
GO:0007155 | TAS | - | cell adhesion | 18538446 |
GO:0007169 | IBA | - | transmembrane receptor protein tyrosine kinase signaling pathway | - |
GO:0007229 | TAS | - | integrin-mediated signaling pathway | 18538446 |
GO:0007498 | TAS | - | mesoderm development | 3453117 |
GO:0008284 | IMP | - | positive regulation of cell proliferation | 10092522 |
GO:0008360 | IMP | - | regulation of cell shape | 10092522 |
GO:0016032 | IEA | - | viral process | - |
GO:0018108 | IMP | - | peptidyl-tyrosine phosphorylation | 10092522 |
GO:0019221 | TAS | - | cytokine-mediated signaling pathway | 18538446 |
GO:0030154 | IBA | - | cell differentiation | - |
GO:0030838 | TAS | - | positive regulation of actin filament polymerization | 18538446 |
GO:0031663 | TAS | - | lipopolysaccharide-mediated signaling pathway | 18538446 |
GO:0038083 | IBA | - | peptidyl-tyrosine autophosphorylation | - |
GO:0038096 | TAS | - | Fc-gamma receptor signaling pathway involved in phagocytosis | - |
GO:0043066 | IMP | - | negative regulation of apoptotic process | 17535448 |
GO:0043299 | TAS | - | leukocyte degranulation | 18538446 |
GO:0045728 | TAS | - | respiratory burst after phagocytosis | 18538446 |
GO:0046777 | IMP | - | protein autophosphorylation | 10092522 |
GO:0050690 | TAS | - | regulation of defense response to virus by virus | - |
GO:0050727 | TAS | - | regulation of inflammatory response | 18538446 |
GO:0050764 | IMP | - | regulation of phagocytosis | 11904303 |
GO:0051090 | IMP | - | regulation of sequence-specific DNA binding transcription factor activity | 17535448 |
GO:0060333 | TAS | - | interferon-gamma-mediated signaling pathway | 18538446 |
GO:0071801 | IDA | - | regulation of podosome assembly | 15998323 |
GO:2000251 | IDA | - | positive regulation of actin cytoskeleton reorganization | 15998323 |
GO:2000251 | IMP | - | positive regulation of actin cytoskeleton reorganization | 11904303 |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
HCK | ABL1 | 106543 | 9407116 | Affinity Capture-Western |
HCK | ABL1 | 109305 | 9407116 | Affinity Capture-Western |
HCK | BCR | 109305 | 10849448 12592324 | Affinity Capture-Western |
HCK | BCR | 107083 | 10849448 12592324 | Affinity Capture-Western |
HCK | BTK | 107160 | 8058772 | Reconstituted Complex |
HCK | BTK | 109305 | 8058772 | Reconstituted Complex |
HCK | CBL | 107315 | 10092522 11896602 | Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex |
HCK | CBL | 109305 | 10092522 11896602 | Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex |
HCK | CCR3 | 109305 | 10527858 | Affinity Capture-Western |
HCK | CCR3 | 107637 | 10527858 | Affinity Capture-Western |
HCK | CSF3R | 107828 | 9790917 | Affinity Capture-Western; Reconstituted Complex |
HCK | CSF3R | 109305 | 9790917 | Affinity Capture-Western; Reconstituted Complex |
HCK | DOK1 | 109305 | 11071635 | Reconstituted Complex |
HCK | DOK1 | 108131 | 11071635 | Reconstituted Complex |
HCK | FCGR1A | 109305 | 8064233 | Affinity Capture-Western |
HCK | FCGR1A | 108503 | 8064233 | Affinity Capture-Western |
HCK | RAPGEF1 | 109305 | 14551197 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
HCK | RAPGEF1 | 109146 | 14551197 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
RASA3 | HCK | 116497 | 7782336 | Affinity Capture-Western; Reconstituted Complex |
RASA3 | HCK | 109305 | 7782336 | Affinity Capture-Western; Reconstituted Complex |
RASA1 | HCK | 111856 | 7782336 | Affinity Capture-Western; Reconstituted Complex |
RASA1 | HCK | 109305 | 7782336 | Affinity Capture-Western; Reconstituted Complex |
BCAR1 | HCK | 114934 | 9020138 | Reconstituted Complex |
BCAR1 | HCK | 109305 | 9020138 | Reconstituted Complex |
SKAP2 | HCK | 109305 | 9837776 | Affinity Capture-Western |
SKAP2 | HCK | 114448 | 9837776 | Affinity Capture-Western |
CHST15 | HCK | 119498 | 10749872 | Affinity Capture-Western |
CHST15 | HCK | 109305 | 10749872 | Affinity Capture-Western |
PECAM1 | HCK | 111201 | 10858437 | Affinity Capture-Western |
PECAM1 | HCK | 109305 | 10858437 | Affinity Capture-Western |
IL6ST | HCK | 109786 | 11689697 | Affinity Capture-Western |
IL6ST | HCK | 109305 | 11689697 | Affinity Capture-Western |
ADAM15 | HCK | 114287 | 11741929 | Biochemical Activity; Reconstituted Complex |
ADAM15 | HCK | 109305 | 11741929 | Biochemical Activity; Reconstituted Complex |
SRC | HCK | 112592 | 11896602 | Affinity Capture-Western |
SRC | HCK | 109305 | 11896602 | Affinity Capture-Western |
UBC | HCK | 113164 | 11896602 | Affinity Capture-Western |
UBC | HCK | 109305 | 11896602 | Affinity Capture-Western |
ELMO1 | HCK | 115180 | 12029088 | Affinity Capture-Western; Reconstituted Complex |
ELMO1 | HCK | 109305 | 12029088 | Affinity Capture-Western; Reconstituted Complex |
WAS | HCK | 113293 | 12029088 | Reconstituted Complex |
WAS | HCK | 109305 | 12029088 | Reconstituted Complex |
WIPF1 | HCK | 113295 | 12029088 | Reconstituted Complex |
WIPF1 | HCK | 109305 | 12029088 | Reconstituted Complex |
RPL10 | HCK | 112054 | 12138090 | Reconstituted Complex |
RPL10 | HCK | 109305 | 12138090 | Reconstituted Complex |
UNC119 | HCK | 114548 | 12496276 | Reconstituted Complex |
UNC119 | HCK | 109305 | 12496276 | Reconstituted Complex |
TRPV4 | HCK | 121883 | 12538589 | Affinity Capture-Western |
TRPV4 | HCK | 109305 | 12538589 | Affinity Capture-Western |
MAP4K5 | HCK | 116353 | 20936779 | Two-hybrid |
MAP4K5 | HCK | 109305 | 20936779 | Two-hybrid |
No data |
No data |
- MGI ID: MGI:96052
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-090313-72