AutismKB 2.0

Annotation Details for HCK


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Basic Information Top
Gene Symbol:HCK ( JTK9 )
Gene Full Name: hemopoietic cell kinase
Band: 20q11.21
Quick LinksEntrez ID:3055; OMIM: 142370; Uniprot ID:HCK_HUMAN; ENSEMBL ID: ENSG00000101336; HGNC ID: 4840
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005764IDA-lysosome15998323
GO:0005794IEA-Golgi apparatus-
GO:0005829TAS-cytosol-
GO:0005884IDAcolocalizes_withactin filament15998323
GO:0005886IDA-plasma membrane-
GO:0005901IDA-caveola7791757
GO:0005925IMP-focal adhesion11904303
GO:0030133IEA-transport vesicle-
GO:0031234IMP-extrinsic component of cytoplasmic side of plasma membrane11904303
GO:0042995IEA-cell projection-
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0004713EXP-protein tyrosine kinase activity10861086
GO:0004713IMP-protein tyrosine kinase activity10092522
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding7859737
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0002522TAS-leukocyte migration involved in immune response18538446
GO:0002758TAS-innate immune response-activating signal transduction18538446
GO:0006468TAS-protein phosphorylation3496523
GO:0006954IEA-inflammatory response-
GO:0007155TAS-cell adhesion18538446
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007229TAS-integrin-mediated signaling pathway18538446
GO:0007498TAS-mesoderm development3453117
GO:0008284IMP-positive regulation of cell proliferation10092522
GO:0008360IMP-regulation of cell shape10092522
GO:0016032IEA-viral process-
GO:0018108IMP-peptidyl-tyrosine phosphorylation10092522
GO:0019221TAS-cytokine-mediated signaling pathway18538446
GO:0030154IBA-cell differentiation-
GO:0030838TAS-positive regulation of actin filament polymerization18538446
GO:0031663TAS-lipopolysaccharide-mediated signaling pathway18538446
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0043066IMP-negative regulation of apoptotic process17535448
GO:0043299TAS-leukocyte degranulation18538446
GO:0045728TAS-respiratory burst after phagocytosis18538446
GO:0046777IMP-protein autophosphorylation10092522
GO:0050690TAS-regulation of defense response to virus by virus-
GO:0050727TAS-regulation of inflammatory response18538446
GO:0050764IMP-regulation of phagocytosis11904303
GO:0051090IMP-regulation of sequence-specific DNA binding transcription factor activity17535448
GO:0060333TAS-interferon-gamma-mediated signaling pathway18538446
GO:0071801IDA-regulation of podosome assembly15998323
GO:2000251IDA-positive regulation of actin cytoskeleton reorganization15998323
GO:2000251IMP-positive regulation of actin cytoskeleton reorganization11904303
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HCKABL11065439407116 Affinity Capture-Western
HCKABL11093059407116 Affinity Capture-Western
HCKBCR10930510849448 12592324 Affinity Capture-Western
HCKBCR10708310849448 12592324 Affinity Capture-Western
HCKBTK1071608058772 Reconstituted Complex
HCKBTK1093058058772 Reconstituted Complex
HCKCBL10731510092522 11896602 Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex
HCKCBL10930510092522 11896602 Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex
HCKCCR310930510527858 Affinity Capture-Western
HCKCCR310763710527858 Affinity Capture-Western
HCKCSF3R1078289790917 Affinity Capture-Western; Reconstituted Complex
HCKCSF3R1093059790917 Affinity Capture-Western; Reconstituted Complex
HCKDOK110930511071635 Reconstituted Complex
HCKDOK110813111071635 Reconstituted Complex
HCKFCGR1A1093058064233 Affinity Capture-Western
HCKFCGR1A1085038064233 Affinity Capture-Western
HCKRAPGEF110930514551197 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HCKRAPGEF110914614551197 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RASA3HCK1164977782336 Affinity Capture-Western; Reconstituted Complex
RASA3HCK1093057782336 Affinity Capture-Western; Reconstituted Complex
RASA1HCK1118567782336 Affinity Capture-Western; Reconstituted Complex
RASA1HCK1093057782336 Affinity Capture-Western; Reconstituted Complex
BCAR1HCK1149349020138 Reconstituted Complex
BCAR1HCK1093059020138 Reconstituted Complex
SKAP2HCK1093059837776 Affinity Capture-Western
SKAP2HCK1144489837776 Affinity Capture-Western
CHST15HCK11949810749872 Affinity Capture-Western
CHST15HCK10930510749872 Affinity Capture-Western
PECAM1HCK11120110858437 Affinity Capture-Western
PECAM1HCK10930510858437 Affinity Capture-Western
IL6STHCK10978611689697 Affinity Capture-Western
IL6STHCK10930511689697 Affinity Capture-Western
ADAM15HCK11428711741929 Biochemical Activity; Reconstituted Complex
ADAM15HCK10930511741929 Biochemical Activity; Reconstituted Complex
SRCHCK11259211896602 Affinity Capture-Western
SRCHCK10930511896602 Affinity Capture-Western
UBCHCK11316411896602 Affinity Capture-Western
UBCHCK10930511896602 Affinity Capture-Western
ELMO1HCK11518012029088 Affinity Capture-Western; Reconstituted Complex
ELMO1HCK10930512029088 Affinity Capture-Western; Reconstituted Complex
WASHCK11329312029088 Reconstituted Complex
WASHCK10930512029088 Reconstituted Complex
WIPF1HCK11329512029088 Reconstituted Complex
WIPF1HCK10930512029088 Reconstituted Complex
RPL10HCK11205412138090 Reconstituted Complex
RPL10HCK10930512138090 Reconstituted Complex
UNC119HCK11454812496276 Reconstituted Complex
UNC119HCK10930512496276 Reconstituted Complex
TRPV4HCK12188312538589 Affinity Capture-Western
TRPV4HCK10930512538589 Affinity Capture-Western
MAP4K5HCK11635320936779 Two-hybrid
MAP4K5HCK10930520936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96052
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090313-72'