AutismKB 2.0

Annotation Details for HCLS1


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Basic Information Top
Gene Symbol:HCLS1 ( CTTNL,HS1 )
Gene Full Name: hematopoietic cell-specific Lyn substrate 1
Band: 3q13.33
Quick LinksEntrez ID:3059; OMIM: 601306; Uniprot ID:HCLS1_HUMAN; ENSEMBL ID: ENSG00000180353; HGNC ID: 4844
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus23001182
GO:0005634ISS-nucleus-
GO:0005667IDA-transcription factor complex23001182
GO:0005737IDA-cytoplasm23001182
GO:0005737ISS-cytoplasm-
GO:0005739IEA-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0001085IPI-RNA polymerase II transcription factor binding23001182
GO:0003779IEA-actin binding-
GO:0005515IPI-protein binding16189514
GO:0017124IEA-SH3 domain binding-
GO:0019901IPI-protein kinase binding23001182
GO:0032403IEA-protein complex binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0006355TAS-regulation of transcription, DNA-templated2587259
GO:0008284ISS-positive regulation of cell proliferation-
GO:0009725ISS-response to hormone-
GO:0014068IMP-positive regulation of phosphatidylinositol 3-kinase signaling23001182
GO:0030041IEA-actin filament polymerization-
GO:0030218ISS-erythrocyte differentiation-
GO:0030833IMP-regulation of actin filament polymerization23001182
GO:0030854IMP-positive regulation of granulocyte differentiation23001182
GO:0033138IMP-positive regulation of peptidyl-serine phosphorylation23001182
GO:0035556TAS-intracellular signal transduction8978766
GO:0042531ISS-positive regulation of tyrosine phosphorylation of STAT protein-
GO:0042993IMP-positive regulation of transcription factor import into nucleus23001182
GO:0045651IEA-positive regulation of macrophage differentiation-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter23001182
GO:0050731IMP-positive regulation of peptidyl-tyrosine phosphorylation23001182
GO:0051897IMP-positive regulation of protein kinase B signaling23001182
GO:0071345IMP-cellular response to cytokine stimulus23001182
GO:2000107IMP-negative regulation of leukocyte apoptotic process23001182
GO:2000251IC-positive regulation of actin cytoskeleton reorganization23001182
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HCLS1CASP310728611689006 11988074 Biochemical Activity
HCLS1CASP310930911689006 11988074 Biochemical Activity
HCLS1CD79A1074117927516 Affinity Capture-Western
HCLS1CD79A1093097927516 Affinity Capture-Western
HCLS1CSNK2A110784111988074 Biochemical Activity
HCLS1CSNK2A110930911988074 Biochemical Activity
HCLS1FGR10855910066823 Reconstituted Complex
HCLS1FGR10930910066823 Reconstituted Complex
HCLS1GRB21091429670936 Reconstituted Complex
HCLS1GRB21093099670936 Reconstituted Complex
LYNHCLS11102457682714 Affinity Capture-Western
LYNHCLS11093097682714 Affinity Capture-Western
MAP4K1HCLS111635410233887 Affinity Capture-Western
MAP4K1HCLS110930910233887 Affinity Capture-Western
ACTR3HCLS110930912534372 Reconstituted Complex
ACTR3HCLS111540312534372 Reconstituted Complex
SH2D4AHCLS112197716189514 Two-hybrid
SH2D4AHCLS110930916189514 Two-hybrid
SSBP3HCLS111717520211142 Two-hybrid
SSBP3HCLS110930920211142 Two-hybrid
TRIM29HCLS111717720211142 Two-hybrid
TRIM29HCLS110930920211142 Two-hybrid
ZBTB25HCLS111342220211142 Two-hybrid
ZBTB25HCLS110930920211142 Two-hybrid
LZTR1HCLS111385220211142 Two-hybrid
LZTR1HCLS110930920211142 Two-hybrid
IKBKGHCLS111408920211142 Two-hybrid
IKBKGHCLS110930920211142 Two-hybrid
BLZF1HCLS111411820211142 Two-hybrid
BLZF1HCLS110930920211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104568
  • Data Attributes: MGI curated and HomoloGene calculated
No data