AutismKB 2.0

Annotation Details for HCRTR1


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Basic Information Top
Gene Symbol:HCRTR1 ( OX1R )
Gene Full Name: hypocretin (orexin) receptor 1
Band: 1p35.2
Quick LinksEntrez ID:3061; OMIM: 602392; Uniprot ID:OX1R_HUMAN; ENSEMBL ID: ENSG00000121764; HGNC ID: 4848
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane26950369
GO ID Evidence Qualifier GO_term References
GO:0004930TAS-G-protein coupled receptor activity9491897
GO:0016499IDA-orexin receptor activity26950369
GO:0017046IEA-peptide hormone binding-
GO:0042277IBA-peptide binding-
GO ID Evidence Qualifier GO_term References
GO:0007218IDA-neuropeptide signaling pathway26950369
GO:0007268TAS-chemical synaptic transmission9491897
GO:0007631IBA-feeding behavior-
GO:0032870IBA-cellular response to hormone stimulus-
GO:0045187IBA-regulation of circadian sleep/wake cycle, sleep-
GO:0051480IDA-regulation of cytosolic calcium ion concentration26950369
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:1901652IBA-response to peptide-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2385650
  • Data Attributes: MGI curated and HomoloGene calculated
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018