AutismKB 2.0

Annotation Details for HGF


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Basic Information Top
Gene Symbol:HGF ( DFNB39,F-TCF,HGFB,HPTA,SF )
Gene Full Name: hepatocyte growth factor (hepapoietin A; scatter factor)
Band: 7q21.11
Quick LinksEntrez ID:3082; OMIM: 142409,608265; Uniprot ID:HGF_HUMAN; ENSEMBL ID: ENSG00000019991; HGNC ID: 4893
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0016020IDA-membrane19946888
GO:0031093TAS-platelet alpha granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004252NASNOTserine-type endopeptidase activity2531289
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding1846706
GO:0008083NAS-growth factor activity2531289
GO:0042056IDA-chemoattractant activity21245381
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000187IEA-activation of MAPK activity-
GO:0000278NAS-mitotic cell cycle2531289
GO:0000902IEA-cell morphogenesis-
GO:0001837TAS-epithelial to mesenchymal transition14679171
GO:0001889IEA-liver development-
GO:0002576TAS-platelet degranulation-
GO:0006508NASNOTproteolysis2531289
GO:0008284IBA-positive regulation of cell proliferation-
GO:0010507NAS-negative regulation of autophagy24743740
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014068IDA-positive regulation of phosphatidylinositol 3-kinase signaling20655899
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030212IEA-hyaluronan metabolic process-
GO:0030335IDA-positive regulation of cell migration21245381
GO:0031100IEA-animal organ regeneration-
GO:0031643IEA-positive regulation of myelination-
GO:0032715IEA-negative regulation of interleukin-6 production-
GO:0032733IEA-positive regulation of interleukin-10 production-
GO:0033137IEA-negative regulation of peptidyl-serine phosphorylation-
GO:0035729IDA-cellular response to hepatocyte growth factor stimulus21245381
GO:0043154IDA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process20655899
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045669NAS-positive regulation of osteoblast differentiation22521434
GO:0045766IEA-positive regulation of angiogenesis-
GO:0045944NAS-positive regulation of transcription from RNA polymerase II promoter22521434
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048012IDA-hepatocyte growth factor receptor signaling pathway21245381
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0050728IEA-negative regulation of inflammatory response-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation21245381
GO:0050918IEA-positive chemotaxis-
GO:0051450IEA-myoblast proliferation-
GO:0060326IDA-cell chemotaxis21245381
GO:0060665IDA-regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling14517989
GO:0070572IEA-positive regulation of neuron projection regeneration-
GO:0090201IDA-negative regulation of release of cytochrome c from mitochondria20655899
GO:1900744IEA-regulation of p38MAPK cascade-
GO:1901299IDA-negative regulation of hydrogen peroxide-mediated programmed cell death20655899
GO:1902042IEA-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:1902947IEA-regulation of tau-protein kinase activity-
GO:2000573IDA-positive regulation of DNA biosynthetic process2531289
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
METHGF1103911655405 8380735 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
METHGF1093301655405 8380735 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SDC2HGF1122858157651 Reconstituted Complex
SDC2HGF1093308157651 Reconstituted Complex
HGFHGF10933011597998 Co-crystal Structure
SDC1HGF11228411830493 Reconstituted Complex
SDC1HGF10933011830493 Reconstituted Complex
CLEC3BHGF10933012694198 Reconstituted Complex
CLEC3BHGF11297812694198 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
NRP1HGF21775515695515 NRP1 (Npn-1) interacts with HGF. This interaction was modeled on a demonstrated interaction between rat NRP1 and human HGF.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96079
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041014-2'