Gene Symbol:	NRG1 ( ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,NDF,SMDF )
Gene Full Name:	neuregulin 1
Band:	8p12
Quick Links	Entrez ID:3084; OMIM: 142445; Uniprot ID:NRG1_HUMAN; ENSEMBL ID: ENSG00000157168; HGNC ID: 7997
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	NAS	-	extracellular region	1348215
GO:0005576	TAS	-	extracellular region	-
GO:0005654	IDA	-	nucleoplasm	-
GO:0005737	IEA	-	cytoplasm	-
GO:0005887	IEA	-	integral component of plasma membrane	-
GO:0009897	IEA	-	external side of plasma membrane	-
GO:0016020	NAS	-	membrane	8096067
GO:0030425	IEA	-	dendrite	-
GO:0030673	IEA	-	axolemma	-
GO:0031594	IEA	-	neuromuscular junction	-
GO:0044297	IEA	-	cell body	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003712	IDA	-	transcription cofactor activity	15073182
GO:0004713	TAS	-	protein tyrosine kinase activity	-
GO:0005088	TAS	-	Ras guanyl-nucleotide exchange factor activity	-
GO:0005125	TAS	-	cytokine activity	10372964
GO:0005176	IEA	-	ErbB-2 class receptor binding	-
GO:0005178	IDA	-	integrin binding	20682778
GO:0008083	NAS	-	growth factor activity	8096067
GO:0030297	NAS	-	transmembrane receptor protein tyrosine kinase activator activity	1348215
GO:0030971	NAS	-	receptor tyrosine kinase binding	1348215
GO:0043125	IDA	-	ErbB-3 class receptor binding	20682778
GO:0045499	IEA	-	chemorepellent activity	-
GO:0046934	TAS	-	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000165	TAS	-	MAPK cascade	-
GO:0000187	IMP	-	activation of MAPK activity	20682778
GO:0000902	IEA	-	cell morphogenesis	-
GO:0001964	IEA	-	startle response	-
GO:0003161	IEA	-	cardiac conduction system development	-
GO:0003222	IDA	-	ventricular trabecula myocardium morphogenesis	17336907
GO:0007154	TAS	-	cell communication	17432114
GO:0007171	IEA	-	activation of transmembrane receptor protein tyrosine kinase activity	-
GO:0007399	TAS	-	nervous system development	17432114
GO:0007416	IEA	-	synapse assembly	-
GO:0007422	IEA	-	peripheral nervous system development	-
GO:0007626	IEA	-	locomotory behavior	-
GO:0008284	IMP	-	positive regulation of cell proliferation	20682778
GO:0008366	IEA	-	axon ensheathment	-
GO:0009790	IEA	-	embryo development	-
GO:0014032	TAS	-	neural crest cell development	17432114
GO:0014066	TAS	-	regulation of phosphatidylinositol 3-kinase signaling	-
GO:0014068	IEA	-	positive regulation of phosphatidylinositol 3-kinase signaling	-
GO:0018108	IEA	-	peptidyl-tyrosine phosphorylation	-
GO:0021781	IEA	-	glial cell fate commitment	-
GO:0021842	IEA	-	chemorepulsion involved in interneuron migration from the subpallium to the cortex	-
GO:0030879	TAS	-	mammary gland development	17432114
GO:0031643	IEA	-	positive regulation of myelination	-
GO:0032148	IMP	-	activation of protein kinase B activity	20682778
GO:0038127	IDA	-	ERBB signaling pathway	11389077
GO:0038127	IMP	-	ERBB signaling pathway	20682778
GO:0038128	TAS	-	ERBB2 signaling pathway	-
GO:0038129	IDA	-	ERBB3 signaling pathway	27353365
GO:0042060	TAS	-	wound healing	16412517
GO:0042177	IEA	-	negative regulation of protein catabolic process	-
GO:0043496	TAS	-	regulation of protein homodimerization activity	16412517
GO:0043497	IDA	-	regulation of protein heterodimerization activity	10559227
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0045213	IEA	-	neurotransmitter receptor metabolic process	-
GO:0045773	IEA	-	positive regulation of axon extension	-
GO:0045892	IDA	-	negative regulation of transcription, DNA-templated	15073182
GO:0045944	IEA	-	positive regulation of transcription from RNA polymerase II promoter	-
GO:0046579	IEA	-	positive regulation of Ras protein signal transduction	-
GO:0046854	IEA	-	phosphatidylinositol phosphorylation	-
GO:0048015	TAS	-	phosphatidylinositol-mediated signaling	-
GO:0048663	IEA	-	neuron fate commitment	-
GO:0048709	IEA	-	oligodendrocyte differentiation	-
GO:0050731	IEA	-	positive regulation of peptidyl-tyrosine phosphorylation	-
GO:0051048	IDA	-	negative regulation of secretion	10559227
GO:0051155	ISS	-	positive regulation of striated muscle cell differentiation	-
GO:0051897	IEA	-	positive regulation of protein kinase B signaling	-
GO:0055007	ISS	-	cardiac muscle cell differentiation	-
GO:0060379	IDA	-	cardiac muscle cell myoblast differentiation	17336907
GO:0060956	IDA	-	endocardial cell differentiation	17336907
GO:0060999	IEA	-	positive regulation of dendritic spine development	-
GO:0070886	IEA	-	positive regulation of calcineurin-NFAT signaling cascade	-
GO:1901185	TAS	-	negative regulation of ERBB signaling pathway	-
GO:1903955	IMP	-	positive regulation of protein targeting to mitochondrion	24270810
GO:2000010	IEA	-	positive regulation of protein localization to cell surface	-
GO:2000145	TAS	-	regulation of cell motility	-
GO:2000727	IEA	-	positive regulation of cardiac muscle cell differentiation	-
GO:2001223	IEA	-	negative regulation of neuron migration	-

Gene Symbol	Interactant	Interaction ID	References	Description
NRG1	EGFR	109332	7730382	Affinity Capture-Western
NRG1	EGFR	108276	7730382	Affinity Capture-Western
NRG1	ERBB2	109332	7592681	Reconstituted Complex
NRG1	ERBB2	108376	7592681	Reconstituted Complex
NRG1	ERBB3	108377	7592681 9168115 11555649	Reconstituted Complex
NRG1	ERBB3	109332	7592681 9168115 11555649	Reconstituted Complex
NRG1	ERBB4	109332	9168115	Reconstituted Complex
NRG1	ERBB4	108378	9168115	Reconstituted Complex
LIMK1	NRG1	109332	9685409	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LIMK1	NRG1	110172	9685409	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for NRG1