AutismKB 2.0

Annotation Details for HIF1A


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Basic Information Top
Gene Symbol:HIF1A ( HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8,bHLHe78 )
Gene Full Name: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Band: 14q23.2
Quick LinksEntrez ID:3091; OMIM: 603348; Uniprot ID:HIF1A_HUMAN; ENSEMBL ID: ENSG00000100644; HGNC ID: 4910
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus8089148
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IPI-transcription factor complex9576906
GO:0005737IDA-cytoplasm19651758
GO:0005829IDA-cytosol24681946
GO:0005829TAS-cytosol-
GO:0016604IDA-nuclear body-
GO:0016607ISS-nuclear speck-
GO:0031514IEA-motile cilium-
GO:0043234IMP-protein complex14594809
GO:0090575IDA-RNA polymerase II transcription factor complex7539918
GO:1904115IEA-axon cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000989IDA-transcription factor activity, transcription factor binding22735262
GO:0001076IEA-transcription factor activity, RNA polymerase II transcription factor binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001228IMP-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding24983504
GO:0002039IPI-p53 binding15629713
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding11782478
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding15261140
GO:0003705IDA-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding8387214
GO:0003705IDAcontributes_totranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding7539918
GO:0005515IPI-protein binding9704006
GO:0008134IPI-transcription factor binding7539918
GO:0019899IPI-enzyme binding11641274
GO:0019901IPI-protein kinase binding20889502
GO:0019904IPI-protein domain specific binding14594809
GO:0031625IPI-ubiquitin protein ligase binding11641274
GO:0035035IPI-histone acetyltransferase binding15261140
GO:0035257IPI-nuclear hormone receptor binding18658046
GO:0042826IEA-histone deacetylase binding-
GO:0043565IDAcontributes_tosequence-specific DNA binding7539918
GO:0046982IPI-protein heterodimerization activity9079689
GO:0046982TAS-protein heterodimerization activity15261140
GO:0051879IDA-Hsp90 protein binding9079689
GO:0070888IEA-E-box binding-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001666IDA-response to hypoxia8756616
GO:0001666IMP-response to hypoxia12411310
GO:0001755IEA-neural crest cell migration-
GO:0001837ISS-epithelial to mesenchymal transition18037992
GO:0001892IEA-embryonic placenta development-
GO:0001922IEA-B-1 B cell homeostasis-
GO:0001938IC-positive regulation of endothelial cell proliferation8756616
GO:0001947IEA-heart looping-
GO:0002052IEA-positive regulation of neuroblast proliferation-
GO:0002248ISS-connective tissue replacement involved in inflammatory response wound healing18037992
GO:0003151IEA-outflow tract morphogenesis-
GO:0003208IEA-cardiac ventricle morphogenesis-
GO:0006089IEA-lactate metabolic process-
GO:0006355IDA-regulation of transcription, DNA-templated11782478
GO:0006366IMP-transcription from RNA polymerase II promoter24048733
GO:0006879IEA-cellular iron ion homeostasis-
GO:0007165IMP-signal transduction12411310
GO:0007595IEA-lactation-
GO:0008542IEA-visual learning-
GO:0010468IDA-regulation of gene expression18419598
GO:0010573IDA-vascular endothelial growth factor production12958148
GO:0010575IDA-positive regulation of vascular endothelial growth factor production8756616
GO:0010575IMP-positive regulation of vascular endothelial growth factor production18658046
GO:0010628IDA-positive regulation of gene expression15459207
GO:0010628IMP-positive regulation of gene expression21817107
GO:0010634ISS-positive regulation of epithelial cell migration18037992
GO:0010870IMP-positive regulation of receptor biosynthetic process17178876
GO:0014850IEA-response to muscle activity-
GO:0016239IEA-positive regulation of macroautophagy-
GO:0016567TAS-protein ubiquitination-
GO:0016579TAS-protein deubiquitination-
GO:0019896IMP-axonal transport of mitochondrion19528298
GO:0021502IEA-neural fold elevation formation-
GO:0021987IEA-cerebral cortex development-
GO:0030502IEA-negative regulation of bone mineralization-
GO:0030949IC-positive regulation of vascular endothelial growth factor receptor signaling pathway8756616
GO:0032007IEA-negative regulation of TOR signaling-
GO:0032364IDA-oxygen homeostasis16956324
GO:0032722TAS-positive regulation of chemokine production18370914
GO:0032909IMP-regulation of transforming growth factor beta2 production12411310
GO:0032963ISS-collagen metabolic process18037992
GO:0035162IEA-embryonic hemopoiesis-
GO:0035774IEA-positive regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0042541IEA-hemoglobin biosynthetic process-
GO:0042593IEA-glucose homeostasis-
GO:0042789IC-mRNA transcription from RNA polymerase II promoter7539918
GO:0043619IDA-regulation of transcription from RNA polymerase II promoter in response to oxidative stress8089148
GO:0043687TAS-post-translational protein modification-
GO:0045648IC-positive regulation of erythrocyte differentiation1448077
GO:0045766IC-positive regulation of angiogenesis8756616
GO:0045766IMP-positive regulation of angiogenesis24048733
GO:0045821IC-positive regulation of glycolytic process8089148
GO:0045893IDA-positive regulation of transcription, DNA-templated8089148
GO:0045893IMP-positive regulation of transcription, DNA-templated21056661
GO:0045926IEA-negative regulation of growth-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter11573933
GO:0045944IGI-positive regulation of transcription from RNA polymerase II promoter9576906
GO:0046716IEA-muscle cell cellular homeostasis-
GO:0046886IDA-positive regulation of hormone biosynthetic process1448077
GO:0048546IEA-digestive tract morphogenesis-
GO:0051000TAS-positive regulation of nitric-oxide synthase activity18254728
GO:0051216IEA-cartilage development-
GO:0051541ISS-elastin metabolic process18037992
GO:0060574IEA-intestinal epithelial cell maturation-
GO:0061030IEA-epithelial cell differentiation involved in mammary gland alveolus development-
GO:0061072IEA-iris morphogenesis-
GO:0061298IEA-retina vasculature development in camera-type eye-
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0061419IDA-positive regulation of transcription from RNA polymerase II promoter in response to hypoxia22735262
GO:0061419IMP-positive regulation of transcription from RNA polymerase II promoter in response to hypoxia19652095
GO:0070101IC-positive regulation of chemokine-mediated signaling pathway17178876
GO:0070244IEA-negative regulation of thymocyte apoptotic process-
GO:0071347IEP-cellular response to interleukin-112958148
GO:0071456IDA-cellular response to hypoxia11573933
GO:0071456IEP-cellular response to hypoxia20810912
GO:0071542IEA-dopaminergic neuron differentiation-
GO:0097411IEA-hypoxia-inducible factor-1alpha signaling pathway-
GO:1902895IMP-positive regulation of pri-miRNA transcription from RNA polymerase II promoter24983504
GO:1903377IDA-negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway24899725
GO:1903599IEA-positive regulation of mitophagy-
GO:1903715IEA-regulation of aerobic respiration-
GO:2000378IEA-negative regulation of reactive oxygen species metabolic process-
GO:2001054IEA-negative regulation of mesenchymal cell apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HIF1APARP110665218314489 Affinity Capture-Western
HIF1APARP110933818314489 Affinity Capture-Western
HIF1AAPEX110682510594042 Reconstituted Complex
HIF1AAPEX110933810594042 Reconstituted Complex
HIF1AARNT1068989079689 11782478 15347669 20562859 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
HIF1AARNT1093389079689 11782478 15347669 20562859 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
HIF1AARNTL1093389576906 Reconstituted Complex; Two-hybrid
HIF1AARNTL1068999576906 Reconstituted Complex; Two-hybrid
HIF1ACREBBP1077779887100 10202154 15154850 16579968 18426857 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
HIF1ACREBBP1093389887100 10202154 15154850 16579968 18426857 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
HIF1AEP30010834711823643 11940656 11959990 14691445 15154850 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
HIF1AEP30010933811823643 11940656 11959990 14691445 15154850 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
HIF1AHDAC110933811641274 16511565 Affinity Capture-Western; Reconstituted Complex
HIF1AHDAC110931511641274 16511565 Affinity Capture-Western; Reconstituted Complex
HIF1AHDAC210933811641274 Reconstituted Complex
HIF1AHDAC210931611641274 Reconstituted Complex
HSP90AA1HIF1A1093389079689 14726529 15147973 16507982 16951198 Affinity Capture-Western; Reconstituted Complex
HSP90AA1HIF1A1095529079689 14726529 15147973 16507982 16951198 Affinity Capture-Western; Reconstituted Complex
TP53HIF1A1093389537326 10640274 12124396 12606552 Affinity Capture-Western; Reconstituted Complex
TP53HIF1A1130109537326 10640274 12124396 12606552 Affinity Capture-Western; Reconstituted Complex
NCOA1HIF1A10933810594042 Reconstituted Complex
NCOA1HIF1A11420010594042 Reconstituted Complex
MDM2HIF1A10933810640274 12606552 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MDM2HIF1A11035810640274 12606552 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DAP3HIF1A10933810903152 Reconstituted Complex
DAP3HIF1A11358710903152 Reconstituted Complex
VHLHIF1A10933810944113 11504942 11566883 11641274 11865071 12004076 12050673 12464182 12538644 12606543 12682018 12808024 12925778 14556007 14600153 14691445 15721254 15805242 16278378 16611863 17047048 17558023 17973296 17981124 18264140 18305400 18426857 18694926 18985005 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex
VHLHIF1A11326910944113 11504942 11566883 11641274 11865071 12004076 12050673 12464182 12538644 12606543 12682018 12808024 12925778 14556007 14600153 14691445 15721254 15805242 16278378 16611863 17047048 17558023 17973296 17981124 18264140 18305400 18426857 18694926 18985005 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex
PSMA7HIF1A11166111389899 Affinity Capture-Western; Reconstituted Complex
PSMA7HIF1A10933811389899 Affinity Capture-Western; Reconstituted Complex
HIF1ANHIF1A12079411641274 Affinity Capture-Western; Reconstituted Complex
HIF1ANHIF1A10933811641274 Affinity Capture-Western; Reconstituted Complex
HDAC3HIF1A10933811641274 Reconstituted Complex
HDAC3HIF1A11436811641274 Reconstituted Complex
JUNHIF1A10933811739718 Affinity Capture-Western
JUNHIF1A10992811739718 Affinity Capture-Western
SHC1HIF1A10933812114320 Affinity Capture-Western
SHC1HIF1A11236112114320 Affinity Capture-Western
UBCHIF1A10933812114320 15382039 15776016 16424018 16611863 17403672 17558023 17875644 17973296 18305400 18426857 18694926 Affinity Capture-Western
UBCHIF1A11316412114320 15382039 15776016 16424018 16611863 17403672 17558023 17875644 17973296 18305400 18426857 18694926 Affinity Capture-Western
ZNF197HIF1A11547012682018 Affinity Capture-Western
ZNF197HIF1A10933812682018 Affinity Capture-Western
PSMC3HIF1A10933814556007 Affinity Capture-Western
PSMC3HIF1A11167514556007 Affinity Capture-Western
HSPA4HIF1A10933814726529 16507982 16951198 Affinity Capture-Western; Reconstituted Complex
HSPA4HIF1A10954014726529 16507982 16951198 Affinity Capture-Western; Reconstituted Complex
VHLLHIF1A13380014757845 Affinity Capture-Western; Reconstituted Complex
VHLLHIF1A10933814757845 Affinity Capture-Western; Reconstituted Complex
MYCHIF1A10933815071503 Affinity Capture-Western
MYCHIF1A11069415071503 Affinity Capture-Western
SMARCA2HIF1A10933815347669 Co-localization
SMARCA2HIF1A11247915347669 Co-localization
SMARCA4HIF1A11248115347669 Co-localization
SMARCA4HIF1A10933815347669 Co-localization
SUMO1HIF1A10933815465032 Affinity Capture-Western
SUMO1HIF1A11318815465032 Affinity Capture-Western
OS9HIF1A11615615721254 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
OS9HIF1A10933815721254 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EGLN3HIF1A12518515721254 18264140 Reconstituted Complex
EGLN3HIF1A10933815721254 18264140 Reconstituted Complex
EGLN1HIF1A12006015721254 16407130 18264140 Reconstituted Complex
EGLN1HIF1A10933815721254 16407130 18264140 Reconstituted Complex
USP20HIF1A11607715776016 Affinity Capture-Western; Biochemical Activity
USP20HIF1A10933815776016 Affinity Capture-Western; Biochemical Activity
SSX4HIF1A10933816189514 Two-hybrid
SSX4HIF1A11263716189514 Two-hybrid
NAA10HIF1A10933816288748 16511565 Affinity Capture-Western; Reconstituted Complex
NAA10HIF1A11388116288748 16511565 Affinity Capture-Western; Reconstituted Complex
SEPT9HIF1A11601516424018 Affinity Capture-Western
SEPT9HIF1A10933816424018 Affinity Capture-Western
MTA1HIF1A10933816511565 16969516 Affinity Capture-Western; Reconstituted Complex
MTA1HIF1A11456216511565 16969516 Affinity Capture-Western; Reconstituted Complex
HDAC6HIF1A10933816951198 Affinity Capture-Western
HDAC6HIF1A11533016951198 Affinity Capture-Western
HDAC4HIF1A11510616951198 19071119 Affinity Capture-Western; Reconstituted Complex
HDAC4HIF1A10933816951198 19071119 Affinity Capture-Western; Reconstituted Complex
MAXHIF1A10933817418410 Affinity Capture-Western
MAXHIF1A11031917418410 Affinity Capture-Western
CUL2HIF1A10933817439941 Affinity Capture-Western
CUL2HIF1A11403117439941 Affinity Capture-Western
TCEB1HIF1A11278317558023 Affinity Capture-Western
TCEB1HIF1A10933817558023 Affinity Capture-Western
SAT2HIF1A12519017558023 Affinity Capture-Western; Reconstituted Complex
SAT2HIF1A10933817558023 Affinity Capture-Western; Reconstituted Complex
GNB2L1HIF1A11567117875644 Reconstituted Complex
GNB2L1HIF1A10933817875644 Reconstituted Complex
SAT1HIF1A11221017875644 Reconstituted Complex
SAT1HIF1A10933817875644 Reconstituted Complex
EGLN2HIF1A12518418264140 Reconstituted Complex
EGLN2HIF1A10933818264140 Reconstituted Complex
NR4A1HIF1A10933818305400 Affinity Capture-Western
NR4A1HIF1A10940718305400 Affinity Capture-Western
STAT3HIF1A10933818985005 Affinity Capture-Western
STAT3HIF1A11265118985005 Affinity Capture-Western
HDAC5HIF1A10933819071119 Affinity Capture-Western; Reconstituted Complex
HDAC5HIF1A11533119071119 Affinity Capture-Western; Reconstituted Complex
BANPHIF1A12030820562859 Affinity Capture-MS
BANPHIF1A10933820562859 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
SP1HIF1A25757515780936 Sp1 interacts with HIF-1alpha.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
HIF1Ars11846496, rs1319462, rs2256605, rs2301113, rs798847 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:106918
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-706'