AutismKB 2.0

Annotation Details for HIP1


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Basic Information Top
Gene Symbol:HIP1 ( ILWEQ,MGC126506 )
Gene Full Name: huntingtin interacting protein 1
Band: 7q11.23
Quick LinksEntrez ID:3092; OMIM: 601767; Uniprot ID:HIP1_HUMAN; ENSEMBL ID: ENSG00000127946; HGNC ID: 4913
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus20074057
GO:0005737IDA-cytoplasm11604514
GO:0005794IDA-Golgi apparatus11788820
GO:0005829TAS-cytosol-
GO:0005856TAS-cytoskeleton9147654
GO:0016020TAS-membrane9147654
GO:0030122IDAcolocalizes_withAP-2 adaptor complex14732715
GO:0030136IDA-clathrin-coated vesicle11517213
GO:0031234IEA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0098793IDA-presynapse20074057
GO:0098794TAS-postsynapse20074057
GO:0098888IEA-extrinsic component of presynaptic membrane-
GO:0098890IEA-extrinsic component of postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0005154TAS-epidermal growth factor receptor binding20074057
GO:0005200TAS-structural constituent of cytoskeleton9140394
GO:0005515IPI-protein binding9140394
GO:0005546IDANOTphosphatidylinositol-4,5-bisphosphate binding14732715
GO:0030276IDA-clathrin binding11577110
GO:0032051IPI-clathrin light chain binding15533940
GO:0032266IDA-phosphatidylinositol-3-phosphate binding14732715
GO:0035091IDA-phosphatidylinositol binding14732715
GO:0035254TAS-glutamate receptor binding20074057
GO:0035612IPI-AP-2 adaptor complex binding15533940
GO:0035615IC-clathrin adaptor activity18790740
GO:0042803IDA-protein homodimerization activity15533940
GO:0043325IDA-phosphatidylinositol-3,4-bisphosphate binding14732715
GO:0046982IPI-protein heterodimerization activity15533940
GO:0051015IDA-actin filament binding18790740
GO:0080025IDA-phosphatidylinositol-3,5-bisphosphate binding14732715
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006915IDA-apoptotic process11788820
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process11788820
GO:0007010IEA-cytoskeleton organization-
GO:0030100NAS-regulation of endocytosis20074057
GO:0030154IEA-cell differentiation-
GO:0042981IDA-regulation of apoptotic process11788820
GO:0045742IMP-positive regulation of epidermal growth factor receptor signaling pathway14732715
GO:0048260IMP-positive regulation of receptor-mediated endocytosis11532990
GO:0048268IDA-clathrin coat assembly11577110
GO:0050821IDA-protein stabilization14732715
GO:0051897IC-positive regulation of protein kinase B signaling14732715
GO:0061024TAS-membrane organization-
GO:0072583IEA-clathrin-dependent endocytosis-
GO:0097190IDA-apoptotic signaling pathway11007801
GO:0099637TAS-neurotransmitter receptor transport20074057
GO:2000588IMP-positive regulation of platelet-derived growth factor receptor-beta signaling pathway14732715
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HIP1CASP810729111788820 Affinity Capture-Western
HIP1CASP810933911788820 Affinity Capture-Western
HIP1CLTC10762311532990 11604514 Affinity Capture-Western; Reconstituted Complex
HIP1CLTC10933911532990 11604514 Affinity Capture-Western; Reconstituted Complex
HIP1HTT1093149147654 11063258 Reconstituted Complex; Two-hybrid
HIP1HTT1093399147654 11063258 Reconstituted Complex; Two-hybrid
IFT57HIP112039611788820 Affinity Capture-Western; Two-hybrid
IFT57HIP110933911788820 Affinity Capture-Western; Two-hybrid
HIP1RHIP111449311889126 Affinity Capture-Western; Reconstituted Complex
HIP1RHIP110933911889126 Affinity Capture-Western; Reconstituted Complex
EIF6HIP110933916169070 Two-hybrid
EIF6HIP110989816169070 Two-hybrid
PFDN1HIP111122316169070 Two-hybrid
PFDN1HIP110933916169070 Two-hybrid
RPS10HIP111211816169070 Two-hybrid
RPS10HIP110933916169070 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
HIP1HTT12821911063258 HIP1 interacts with HD.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1099804
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010328-15'