AutismKB 2.0

Annotation Details for HK2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HK2 ( DKFZp686M1669,HKII,HXK2 )
Gene Full Name: hexokinase 2
Band: 2p12
Quick LinksEntrez ID:3099; OMIM: 601125; Uniprot ID:HXK2_HUMAN; ENSEMBL ID: ENSG00000159399; HGNC ID: 4923
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005741IDA-mitochondrial outer membrane18350175
GO:0005829IBA-cytosol-
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO ID Evidence Qualifier GO_term References
GO:0004340IBA-glucokinase activity-
GO:0004340TAS-glucokinase activity-
GO:0004396TAS-hexokinase activity9278438
GO:0005515IPI-protein binding16189514
GO:0005524IEA-ATP binding-
GO:0005536IEA-glucose binding-
GO:0008865IBA-fructokinase activity-
GO:0019158IBA-mannokinase activity-
GO ID Evidence Qualifier GO_term References
GO:0001678IBA-cellular glucose homeostasis-
GO:0002931IEA-response to ischemia-
GO:0006096TAS-glycolytic process23962723
GO:0007595IEA-lactation-
GO:0008637IDA-apoptotic mitochondrial changes18350175
GO:0015758TAS-glucose transport-
GO:0035795IEA-negative regulation of mitochondrial membrane permeability-
GO:0046324IEA-regulation of glucose import-
GO:0046835IEA-carbohydrate phosphorylation-
GO:0051156IEA-glucose 6-phosphate metabolic process-
GO:0061621TAS-canonical glycolysis-
GO:0072655IMP-establishment of protein localization to mitochondrion23962723
GO:0072656IMP-maintenance of protein location in mitochondrion23962723
GO:1904925IMP-positive regulation of mitophagy in response to mitochondrial depolarization23962723
GO:2000378IEA-negative regulation of reactive oxygen species metabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKCEHK211156712663490 Affinity Capture-Western
PRKCEHK210934612663490 Affinity Capture-Western
UBQLN1HK211900716189514 Two-hybrid
UBQLN1HK210934616189514 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
PTGDSHK217176811068878 HKII interacts with PGDS. This interaction was modeled on a demonstrated interaction between rat HKII and human PGDS.
IGFBP4HK217176711068878 HKII interacts with IGFBP-4. This interaction was modeled on a demonstrated interaction between rat HKII and human IGFBP-4.
ZBTB17HK217177011068878 HKII interacts with Miz-1. This interaction was modeled on a demonstrated interaction between rat HKII and human Miz-1.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
HK2rs2229621, rs8192672 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1315197
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2017'