AutismKB 2.0

Annotation Details for HLA-A


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Basic Information Top
Gene Symbol:HLA-A ( FLJ26655,HLAA )
Gene Full Name: major histocompatibility complex, class I, A
Band: 6p22.1
Quick LinksEntrez ID:3105; OMIM: 142800; Uniprot ID:1A03_HUMAN; ENSEMBL ID: ENSG00000206503; HGNC ID: 4931
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005783ISS-endoplasmic reticulum-
GO:0005794ISS-Golgi apparatus-
GO:0005886IBA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0009986ISS-cell surface-
GO:0012507TAS-ER to Golgi transport vesicle membrane-
GO:0030670TAS-phagocytic vesicle membrane-
GO:0031901TAS-early endosome membrane-
GO:0042612ISS-MHC class I protein complex-
GO:0055038TAS-recycling endosome membrane-
GO:0071556TAS-integral component of lumenal side of endoplasmic reticulum membrane-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding23401559
GO:0030881IMP-beta-2-microglobulin binding23566939
GO:0030881ISS-beta-2-microglobulin binding-
GO:0042605IMP-peptide antigen binding23566939
GO:0042605ISS-peptide antigen binding-
GO ID Evidence Qualifier GO_term References
GO:0002474IBA-antigen processing and presentation of peptide antigen via MHC class I-
GO:0002474TAS-antigen processing and presentation of peptide antigen via MHC class I-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0002480TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent-
GO:0016032IEA-viral process-
GO:0050776TAS-regulation of immune response-
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0060337TAS-type I interferon signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HLA-ACD8A1073639177355 10809759 Co-crystal Structure; Reconstituted Complex
HLA-ACD8A1093509177355 10809759 Co-crystal Structure; Reconstituted Complex
HLA-ACOPB110771011884415 Affinity Capture-Western
HLA-ACOPB110935011884415 Affinity Capture-Western
KIR3DL2HLA-A1100138617928 Reconstituted Complex
KIR3DL2HLA-A1093508617928 Reconstituted Complex
MAGEA1HLA-A1102748647853 Reconstituted Complex
MAGEA1HLA-A1093508647853 Reconstituted Complex
TRA@HLA-A1128159586631 Co-crystal Structure
TRA@HLA-A1093509586631 Co-crystal Structure
TRB@HLA-A1128179586631 Co-crystal Structure
TRB@HLA-A1093509586631 Co-crystal Structure
MAGEA4HLA-A11027711502003 Co-crystal Structure
MAGEA4HLA-A10935011502003 Co-crystal Structure
UBCHLA-A11316411756476 Affinity Capture-Western
UBCHLA-A10935011756476 Affinity Capture-Western
COPGHLA-A11649611884415 Affinity Capture-Western
COPGHLA-A10935011884415 Affinity Capture-Western
TAP1HLA-A11275311884415 Affinity Capture-Western
TAP1HLA-A10935011884415 Affinity Capture-Western
TAPBPHLA-A11275511884415 Affinity Capture-Western
TAPBPHLA-A10935011884415 Affinity Capture-Western
LILRB1HLA-A11607012897781 Co-crystal Structure
LILRB1HLA-A10935012897781 Co-crystal Structure
DERL1HLA-A12255915215855 Affinity Capture-Western
DERL1HLA-A10935015215855 Affinity Capture-Western
UGGT1HLA-A12121717353931 Affinity Capture-MS
UGGT1HLA-A10935017353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
HLA-AHLA-A Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:95929
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018