AutismKB 2.0

Annotation Details for HLA-G


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Basic Information Top
Gene Symbol:HLA-G ( MHC-G )
Gene Full Name: major histocompatibility complex, class I, G
Band: 6p22.1
Quick LinksEntrez ID:3135; OMIM: 142871; Uniprot ID:HLAG_HUMAN; ENSEMBL ID: ENSG00000204632; HGNC ID: 4964
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005886IBA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0012507TAS-ER to Golgi transport vesicle membrane-
GO:0016020IDA-membrane19946888
GO:0030670TAS-phagocytic vesicle membrane-
GO:0031901TAS-early endosome membrane-
GO:0042612IEA-MHC class I protein complex-
GO:0055038TAS-recycling endosome membrane-
GO:0071556TAS-integral component of lumenal side of endoplasmic reticulum membrane-
GO ID Evidence Qualifier GO_term References
GO:0005102IPI-receptor binding20702625
GO:0042605IBA-peptide antigen binding-
GO:0042803IDA-protein homodimerization activity22802125
GO:0042803NAS-protein homodimerization activity18550825
GO ID Evidence Qualifier GO_term References
GO:0002474IBA-antigen processing and presentation of peptide antigen via MHC class I-
GO:0002474TAS-antigen processing and presentation of peptide antigen via MHC class I-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0002480TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent-
GO:0002645IMP-positive regulation of tolerance induction22802125
GO:0002666IMP-positive regulation of T cell tolerance induction20448110
GO:0002767IDA-immune response-inhibiting cell surface receptor signaling pathway20702625
GO:0006968TAS-cellular defense response9539768
GO:0032735IDA-positive regulation of interleukin-12 production20702625
GO:0042130IDA-negative regulation of T cell proliferation20702625
GO:0045591IMP-positive regulation of regulatory T cell differentiation20448110
GO:0050776TAS-regulation of immune response-
GO:0050777IC-negative regulation of immune response22802125
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0060337TAS-type I interferon signaling pathway-
GO:2001199IDA-negative regulation of dendritic cell differentiation20702625
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HLA-GCD8A1073631908512 10809759 Reconstituted Complex
HLA-GCD8A1093801908512 10809759 Reconstituted Complex
HLA-GCOPB110938012582157 Affinity Capture-Western
HLA-GCOPB110771012582157 Affinity Capture-Western
TAP1HLA-G1093809103419 Affinity Capture-Western
TAP1HLA-G1127539103419 Affinity Capture-Western
TAP2HLA-G1093809103419 Affinity Capture-Western
TAP2HLA-G1127549103419 Affinity Capture-Western
KIR2DL4HLA-G10938010190900 Reconstituted Complex
KIR2DL4HLA-G11000610190900 Reconstituted Complex
HLA-GHLA-G10938012454284 12874224 Affinity Capture-Western; Co-purification
LILRB2HLA-G11557712853576 Reconstituted Complex
LILRB2HLA-G10938012853576 Reconstituted Complex
LILRB1HLA-G10938012853576 Reconstituted Complex
LILRB1HLA-G11607012853576 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95915
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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