AutismKB 2.0

Annotation Details for HMGB1


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Basic Information Top
Gene Symbol:HMGB1 ( DKFZp686A04236,HMG1,HMG3,SBP-1 )
Gene Full Name: high-mobility group box 1
Band: 13q12.3
Quick LinksEntrez ID:3146; OMIM: 163905; Uniprot ID:HMGB1_HUMAN; ENSEMBL ID: ENSG00000189403; HGNC ID: 4983
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000793IDA-condensed chromosome12925773
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space19841752
GO:0005634IDA-nucleus8339930
GO:0005654TAS-nucleoplasm-
GO:0005769IEA-early endosome-
GO:0005793IEA-endoplasmic reticulum-Golgi intermediate compartment-
GO:0005886IEA-plasma membrane-
GO:0009986IDA-cell surface19841752
GO:0017053IDAcolocalizes_withtranscriptional repressor complex19158276
GO:0034774TAS-secretory granule lumen-
GO:0043005IEA-neuron projection-
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0000400ISS-four-way junction DNA binding-
GO:0000405ISS-bubble DNA binding-
GO:0001530IDA-lipopolysaccharide binding21660935
GO:0001786IDA-phosphatidylserine binding18768881
GO:0003684IDA-damaged DNA binding17803946
GO:0003684ISS-damaged DNA binding-
GO:0003690ISS-double-stranded DNA binding-
GO:0003697ISS-single-stranded DNA binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding19223331
GO:0003723IDA-RNA binding22658674
GO:0003725IEA-double-stranded RNA binding-
GO:0003727IEA-single-stranded RNA binding-
GO:0005125ISS-cytokine activity-
GO:0005515IPI-protein binding8006019
GO:0008134IPI-transcription factor binding19223331
GO:0008301IMP-DNA binding, bending19223331
GO:0008301ISS-DNA binding, bending-
GO:0010858IEA-calcium-dependent protein kinase regulator activity-
GO:0016829IDA-lyase activity17803946
GO:0019958IDA-C-X-C chemokine binding22370717
GO:0030295IEA-protein kinase activator activity-
GO:0042056ISS-chemoattractant activity-
GO:0050786ISS-RAGE receptor binding-
GO:0070182IDA-DNA polymerase binding17803946
GO:0070491IPI-repressing transcription factor binding19223331
GO:0097100ISS-supercoiled DNA binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter19158276
GO:0001654IEA-eye development-
GO:0001773ISS-myeloid dendritic cell activation-
GO:0001935IEA-endothelial cell proliferation-
GO:0002218IDA-activation of innate immune response24971542
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002270IEA-plasmacytoid dendritic cell activation-
GO:0002281IEA-macrophage activation involved in immune response-
GO:0002407ISS-dendritic cell chemotaxis-
GO:0002437IEP-inflammatory response to antigenic stimulus19841752
GO:0002643IDA-regulation of tolerance induction18631454
GO:0002840ISS-regulation of T cell mediated immune response to tumor cell-
GO:0006265ISS-DNA topological change-
GO:0006284IEA-base-excision repair-
GO:0006309TAS-apoptotic DNA fragmentation-
GO:0006310ISS-DNA recombination-
GO:0006357IDA-regulation of transcription from RNA polymerase II promoter11748232
GO:0006914IEA-autophagy-
GO:0006954IDA-inflammatory response23146691
GO:0007204IDA-positive regulation of cytosolic calcium ion concentration22370717
GO:0010506IMP-regulation of autophagy20819940
GO:0017055IDA-negative regulation of RNA polymerase II transcriptional preinitiation complex assembly8006019
GO:0030324IEA-lung development-
GO:0031175ISS-neuron projection development-
GO:0031497IEA-chromatin assembly-
GO:0032072IDA-regulation of restriction endodeoxyribonuclease activity17803946
GO:0032147IEA-activation of protein kinase activity-
GO:0032392ISS-DNA geometric change-
GO:0032425IDA-positive regulation of mismatch repair15014079
GO:0032689IDA-negative regulation of interferon-gamma production22473704
GO:0032727IEA-positive regulation of interferon-alpha production-
GO:0032728IEA-positive regulation of interferon-beta production-
GO:0032733IDA-positive regulation of interleukin-10 production22473704
GO:0032735IMP-positive regulation of interleukin-12 production15944249
GO:0032760IEA-positive regulation of tumor necrosis factor production-
GO:0033151IDA-V(D)J recombination9166431
GO:0034137IEA-positive regulation of toll-like receptor 2 signaling pathway-
GO:0034145IEA-positive regulation of toll-like receptor 4 signaling pathway-
GO:0034165ISS-positive regulation of toll-like receptor 9 signaling pathway-
GO:0035711IDA-T-helper 1 cell activation22473704
GO:0035767IEA-endothelial cell chemotaxis-
GO:0042104IMP-positive regulation of activated T cell proliferation15944249
GO:0043065IDA-positive regulation of apoptotic process19800306
GO:0043277IDA-apoptotic cell clearance18768881
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process19800306
GO:0043312TAS-neutrophil degranulation-
GO:0043371IDA-negative regulation of CD4-positive, alpha-beta T cell differentiation22473704
GO:0043388IDA-positive regulation of DNA binding11748232
GO:0043410IDA-positive regulation of MAPK cascade12765338
GO:0043537IDA-negative regulation of blood vessel endothelial cell migration23148224
GO:0045063IMP-T-helper 1 cell differentiation15944249
GO:0045087TAS-innate immune response-
GO:0045639IEA-positive regulation of myeloid cell differentiation-
GO:0045819IEA-positive regulation of glycogen catabolic process-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter19223331
GO:0046330IDA-positive regulation of JNK cascade12765338
GO:0050716IDA-positive regulation of interleukin-1 secretion12765338
GO:0050718IEA-positive regulation of interleukin-1 beta secretion-
GO:0050918IEA-positive chemotaxis-
GO:0051103ISS-DNA ligation involved in DNA repair-
GO:0051106ISS-positive regulation of DNA ligation-
GO:0051384IEA-response to glucocorticoid-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade22370717
GO:0090026IDA-positive regulation of monocyte chemotaxis22370717
GO:0090303IEA-positive regulation of wound healing-
GO:0097350IDA-neutrophil clearance18768881
GO:1901224IEA-positive regulation of NIK/NF-kappaB signaling-
GO:1903672IEA-positive regulation of sprouting angiogenesis-
GO:1990774IDA-tumor necrosis factor secretion12765338
GO:2000426IEA-negative regulation of apoptotic cell clearance-
GO:2000778IDA-positive regulation of interleukin-6 secretion12765338
GO:2000819IEA-regulation of nucleotide-excision repair-
GO:2001200IMP-positive regulation of dendritic cell differentiation15944249
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HMGB1AES10938911748221 Reconstituted Complex
HMGB1AES10667511748221 Reconstituted Complex
HMGB1AR1093899671457 Reconstituted Complex
HMGB1AR1068629671457 Reconstituted Complex
HMGB1CDK11093892013279 Biochemical Activity; Reconstituted Complex
HMGB1CDK11074202013279 Biochemical Activity; Reconstituted Complex
HMGB1CREBBP10777715005629 Biochemical Activity
HMGB1CREBBP10938915005629 Biochemical Activity
HMGB1CRMP110779016169070 Two-hybrid
HMGB1CRMP110938916169070 Two-hybrid
HMGB1CSNK1A110938912062430 Co-purification
HMGB1CSNK1A110783612062430 Co-purification
HMGB1NCAN1093899507007 Reconstituted Complex
HMGB1NCAN1078459507007 Reconstituted Complex
HMGB1NR3C11091659671457 Reconstituted Complex
HMGB1NR3C11093899671457 Reconstituted Complex
HMGB1GTF2A11092129880542 Reconstituted Complex
HMGB1GTF2A11093899880542 Reconstituted Complex
HMGB1H3F3A10938917403666 Affinity Capture-MS
HMGB1H3F3A10927217403666 Affinity Capture-MS
PLGHMGB11113561909331 Reconstituted Complex
PLGHMGB11093891909331 Reconstituted Complex
TBPHMGB11093898006019 9880542 Reconstituted Complex
TBPHMGB11127718006019 9880542 Reconstituted Complex
PLATHMGB11113438366113 Co-purification
PLATHMGB11093898366113 Co-purification
HOXB1HMGB11094518890171 Reconstituted Complex
HOXB1HMGB11093898890171 Reconstituted Complex
HOXB3HMGB11094538890171 Reconstituted Complex
HOXB3HMGB11093898890171 Reconstituted Complex
HOXC6HMGB11094638890171 Reconstituted Complex
HOXC6HMGB11093898890171 Reconstituted Complex
HOXD3HMGB11094728890171 Reconstituted Complex
HOXD3HMGB11093898890171 Reconstituted Complex
HOXD8HMGB11094748890171 Reconstituted Complex
HOXD8HMGB11093898890171 Reconstituted Complex
HOXD9HMGB11094758890171 Reconstituted Complex
HOXD9HMGB11093898890171 Reconstituted Complex
HOXD10HMGB11094768890171 Reconstituted Complex
HOXD10HMGB11093898890171 Reconstituted Complex
HOXD11HMGB11094778890171 Reconstituted Complex
HOXD11HMGB11093898890171 Reconstituted Complex
PTPRZ1HMGB11093899507007 Reconstituted Complex
PTPRZ1HMGB11117679507007 Reconstituted Complex
PGRHMGB11112609671457 Reconstituted Complex
PGRHMGB11093899671457 Reconstituted Complex
RAG1HMGB110938910490593 Reconstituted Complex
RAG1HMGB111183210490593 Reconstituted Complex
POU5F1HMGB111145611099378 Affinity Capture-Western
POU5F1HMGB110938911099378 Affinity Capture-Western
TP53HMGB111301011106654 11748221 Affinity Capture-Western; Reconstituted Complex
TP53HMGB110938911106654 11748221 Affinity Capture-Western; Reconstituted Complex
HNRNPKHMGB110943111748221 Reconstituted Complex
HNRNPKHMGB110938911748221 Reconstituted Complex
MECP2HMGB111036811748221 Reconstituted Complex
MECP2HMGB110938911748221 Reconstituted Complex
RB1HMGB111186011748221 Reconstituted Complex
RB1HMGB110938911748221 Reconstituted Complex
TLE1HMGB111294311748221 Reconstituted Complex
TLE1HMGB110938911748221 Reconstituted Complex
TP73HMGB111301411748232 Reconstituted Complex
TP73HMGB110938911748232 Reconstituted Complex
NFKB1HMGB111085712604365 Reconstituted Complex
NFKB1HMGB110938912604365 Reconstituted Complex
RELAHMGB111190212665595 Affinity Capture-Western
RELAHMGB110938912665595 Affinity Capture-Western
C14orf1HMGB111633216169070 Two-hybrid
C14orf1HMGB110938916169070 Two-hybrid
C1orf103HMGB112090516169070 Two-hybrid
C1orf103HMGB110938916169070 Two-hybrid
UNC119HMGB111454816169070 Two-hybrid
UNC119HMGB110938916169070 Two-hybrid
UBCHMGB111316418655026 Affinity Capture-MS
UBCHMGB110938918655026 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96113
  • Data Attributes: MGI curated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-341'