AutismKB 2.0

Annotation Details for HMGA1


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Basic Information Top
Gene Symbol:HMGA1 ( HMG-R,HMGA1A,HMGIY,MGC12816,MGC4242,MGC4854 )
Gene Full Name: high mobility group AT-hook 1
Band: 6p21.31
Quick LinksEntrez ID:3159; OMIM: 600701; Uniprot ID:HMGA1_HUMAN; ENSEMBL ID: ENSG00000137309; HGNC ID: 5010
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16791210
GO:0005654TAS-nucleoplasm-
GO:0005667TAS-transcription factor complex10428834
GO:0005829TAS-cytosol-
GO:0005925IDA-focal adhesion21423176
GO:0035985IDA-senescence-associated heterochromatin focus16901784
GO:0090575ISS-RNA polymerase II transcription factor complex-
GO ID Evidence Qualifier GO_term References
GO:0001158IDA-enhancer sequence-specific DNA binding9253416
GO:0001205ISS-transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding-
GO:0003677TAS-DNA binding10871404
GO:0003680IDA-AT DNA binding9253416
GO:0003680ISS-AT DNA binding-
GO:0003680TAS-AT DNA binding10428834
GO:0003682ISS-chromatin binding-
GO:0003700IBA-transcription factor activity, sequence-specific DNA binding-
GO:0003906IBA-DNA-(apurinic or apyrimidinic site) lyase activity-
GO:0005515IPI-protein binding10428834
GO:0008134IDA-transcription factor binding10428834
GO:0019899IPI-enzyme binding16157300
GO:0030374IMP-ligand-dependent nuclear receptor transcription coactivator activity10428834
GO:0042974IDA-retinoic acid receptor binding10428834
GO:0042975IDA-peroxisome proliferator activated receptor binding10428834
GO:0046965IDA-retinoid X receptor binding10428834
GO ID Evidence Qualifier GO_term References
GO:0006268NAS-DNA unwinding involved in DNA replication10428834
GO:0006284IBA-base-excision repair-
GO:0006337TAS-nucleosome disassembly10428834
GO:0006355TAS-regulation of transcription, DNA-templated10871404
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006461TAS-protein complex assembly10428834
GO:0008285IMP-negative regulation of cell proliferation16901784
GO:0009615IEP-response to virus17005673
GO:0031936TAS-negative regulation of chromatin silencing10428834
GO:0035986IDA-senescence-associated heterochromatin focus assembly16901784
GO:0045892IMP-negative regulation of transcription, DNA-templated16901784
GO:0045893IMP-positive regulation of transcription, DNA-templated10428834
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0051169TAS-nuclear transport-
GO:0075713TAS-establishment of integrated proviral latency-
GO:0090402IDA-oncogene-induced cell senescence16901784
GO:2000774IMP-positive regulation of cellular senescence16901784
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HMGA1PARP110665216204234 Reconstituted Complex
HMGA1PARP110940216204234 Reconstituted Complex
HMGA1CEBPB10940212665574 Affinity Capture-Western; Reconstituted Complex
HMGA1CEBPB10748012665574 Affinity Capture-Western; Reconstituted Complex
HMGA1CHD110753018817785 Affinity Capture-Western
HMGA1CHD110940218817785 Affinity Capture-Western
HMGA1ATF210940210357819 Reconstituted Complex
HMGA1ATF210777610357819 Reconstituted Complex
HMGA1CREBBP1077779809067 10428834 Biochemical Activity; Two-hybrid
HMGA1CREBBP1094029809067 10428834 Biochemical Activity; Two-hybrid
HMGA1ELF11094027862168 Reconstituted Complex
HMGA1ELF11083127862168 Reconstituted Complex
HMGA1EWSR110843116189514 Two-hybrid
HMGA1EWSR110940216189514 Two-hybrid
POU3F1HMGA11094027791781 Reconstituted Complex
POU3F1HMGA11114497791781 Reconstituted Complex
NFYAHMGA11108669388234 Far Western
NFYAHMGA11094029388234 Far Western
KAT2BHMGA11143759809067 Biochemical Activity
KAT2BHMGA11094029809067 Biochemical Activity
NFKB1HMGA11094029809067 Reconstituted Complex
NFKB1HMGA11108579809067 Reconstituted Complex
POU2F1HMGA11094029823775 Far Western; Reconstituted Complex
POU2F1HMGA11114479823775 Far Western; Reconstituted Complex
POU2F2HMGA11094029823775 Far Western; Reconstituted Complex
POU2F2HMGA11114489823775 Far Western; Reconstituted Complex
IRF1HMGA110986710357819 Reconstituted Complex
IRF1HMGA110940210357819 Reconstituted Complex
JUNHMGA110992810357819 10428834 Reconstituted Complex; Two-hybrid
JUNHMGA110940210357819 10428834 Reconstituted Complex; Two-hybrid
PPARGHMGA110940210428834 18310298 Reconstituted Complex; Two-hybrid
PPARGHMGA111146410428834 18310298 Reconstituted Complex; Two-hybrid
RARAHMGA111184910428834 Reconstituted Complex; Two-hybrid
RARAHMGA110940210428834 Reconstituted Complex; Two-hybrid
PRKCAHMGA110940210889043 Biochemical Activity
PRKCAHMGA111156410889043 Biochemical Activity
SP1HMGA110940212665574 Affinity Capture-Western; Reconstituted Complex
SP1HMGA111255012665574 Affinity Capture-Western; Reconstituted Complex
PRMT6HMGA110940216157300 16293633 Affinity Capture-Western; Biochemical Activity; Far Western
PRMT6HMGA112046916157300 16293633 Affinity Capture-Western; Biochemical Activity; Far Western
NPM1HMGA111092916293633 Far Western
NPM1HMGA110940216293633 Far Western
BANF1HMGA110940219759913 Affinity Capture-MS
BANF1HMGA111434219759913 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
INSRHMGA131427215924147 HMGA1 interacts with INSR locus.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96160
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010502-1'