AutismKB 2.0

Annotation Details for APAF1


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Basic Information Top
Gene Symbol:APAF1 ( APAF-1,CED4,DKFZp781B1145 )
Gene Full Name: apoptotic peptidase activating factor 1
Band: 12q23.1
Quick LinksEntrez ID:317; OMIM: 602233; Uniprot ID:APAF_HUMAN; ENSEMBL ID: ENSG00000120868; HGNC ID: 576
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IEA-nucleus-
GO:0005829TAS-cytosol-
GO:0034774TAS-secretory granule lumen-
GO:0043293IDA-apoptosome21827945
GO:0043293TAS-apoptosome18309324
GO:0070062IDA-extracellular exosome19056867
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0000166TAS-nucleotide binding10383829
GO:0005515IPI-protein binding9267021
GO:0005524IEA-ATP binding-
GO:0008656IBA-cysteine-type endopeptidase activator activity involved in apoptotic process-
GO:0008656NAS-cysteine-type endopeptidase activator activity involved in apoptotic process15009102
GO:0031072IEA-heat shock protein binding-
GO:0042802IEA-identical protein binding-
GO:0043531IEA-ADP binding-
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0001843IEA-neural tube closure-
GO:0006915TAS-apoptotic process9753320
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process21827945
GO:0007399TAS-nervous system development9753320
GO:0007568IEA-aging-
GO:0007584IEA-response to nutrient-
GO:0008635IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c9267021
GO:0008635TAS-activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c-
GO:0010659IEA-cardiac muscle cell apoptotic process-
GO:0030154IEA-cell differentiation-
GO:0030900IEA-forebrain development-
GO:0034349IEA-glial cell apoptotic process-
GO:0042981TAS-regulation of apoptotic process10441496
GO:0043065TAS-positive regulation of apoptotic process18309324
GO:0043312TAS-neutrophil degranulation-
GO:0051260IEA-protein homooligomerization-
GO:0051402IEA-neuron apoptotic process-
GO:0070059IEA-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-
GO:0071560IEA-cellular response to transforming growth factor beta stimulus-
GO:0072432TAS-response to G1 DNA damage checkpoint signaling18309324
GO:0097193TAS-intrinsic apoptotic signaling pathway18309324
GO:1902510IEA-regulation of apoptotic DNA fragmentation-
GO:2001235IEA-positive regulation of apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CYCSAPAF11199229267021 Affinity Capture-Western
CYCSAPAF11068149267021 Affinity Capture-Western
CASP9APAF11068149390557 9488720 9539746 11113115 15262985 Affinity Capture-Western; Reconstituted Complex
CASP9APAF11072929390557 9488720 9539746 11113115 15262985 Affinity Capture-Western; Reconstituted Complex
BCL2L1APAF11068149488720 9539746 Affinity Capture-Western
BCL2L1APAF11070709488720 9539746 Affinity Capture-Western
CASP4APAF11072879539746 Affinity Capture-Western
CASP4APAF11068149539746 Affinity Capture-Western
CASP8APAF11068149539746 Affinity Capture-Western
CASP8APAF11072919539746 Affinity Capture-Western
HSP90AA1APAF110955210934467 Affinity Capture-Western
HSP90AA1APAF110681410934467 Affinity Capture-Western
HSPA4APAF110954010934467 Affinity Capture-Western; Co-purification; Reconstituted Complex
HSPA4APAF110681410934467 Affinity Capture-Western; Co-purification; Reconstituted Complex
AVENAPAF110681410949025 Affinity Capture-Western
AVENAPAF112136610949025 Affinity Capture-Western
NLRP1APAF110681411113115 Affinity Capture-Western; Co-purification
NLRP1APAF111652911113115 Affinity Capture-Western; Co-purification
APIPAPAF111926515262985 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APIPAPAF110681415262985 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
APAF1rs2278361, rs2288713, rs2288729 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:1306796
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000616-4'