AutismKB 2.0

Annotation Details for APBB1


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Basic Information Top
Gene Symbol:APBB1 ( FE65,MGC:9072,RIR )
Gene Full Name: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Band: 11p15.4
Quick LinksEntrez ID:322; OMIM: 602709; Uniprot ID:APBB1_HUMAN; ENSEMBL ID: ENSG00000166313; HGNC ID: 581
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus18468999
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm18468999
GO:0005886IDA-plasma membrane18468999
GO:0016607IEA-nuclear speck-
GO:0030027IDA-lamellipodium12843239
GO:0030426IDA-growth cone12843239
GO:0042734IEA-presynaptic membrane-
GO:0043025IEA-neuronal cell body-
GO:0043197IEA-dendritic spine-
GO:0043234IEA-protein complex-
GO:0044304IEA-main axon-
GO:0045202IDA-synapse12843239
GO:0045211IEA-postsynaptic membrane-
GO:0048471IEA-perinuclear region of cytoplasm-
GO:1990761IEA-growth cone lamellipodium-
GO:1990812IEA-growth cone filopodium-
GO ID Evidence Qualifier GO_term References
GO:0001540IPI-amyloid-beta binding18468999
GO:0001540NAS-amyloid-beta binding8894693
GO:0003682IDA-chromatin binding19343227
GO:0005515IPI-protein binding8887653
GO:0008134IBA-transcription factor binding-
GO:0008134ISS-transcription factor binding-
GO:0032403IEA-protein complex binding-
GO:0042393IPI-histone binding19234442
GO:0048156IEA-tau protein binding-
GO:0070064IPI-proline-rich region binding17686488
GO ID Evidence Qualifier GO_term References
GO:0000122IGI-negative regulation of transcription from RNA polymerase II promoter21803450
GO:0006302IEA-double-strand break repair-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355ISS-regulation of transcription, DNA-templated-
GO:0006915IEA-apoptotic process-
GO:0006974IDA-cellular response to DNA damage stimulus18468999
GO:0007050ISS-cell cycle arrest-
GO:0007165NAS-signal transduction8894693
GO:0007409NAS-axonogenesis12843239
GO:0010039IEA-response to iron ion-
GO:0010976IEA-positive regulation of neuron projection development-
GO:0030308ISS-negative regulation of cell growth-
GO:0043065IDA-positive regulation of apoptotic process18468999
GO:0043967ISS-histone H4 acetylation-
GO:0045739IEA-positive regulation of DNA repair-
GO:0045893IDA-positive regulation of transcription, DNA-templated19343227
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0050714IEA-positive regulation of protein secretion-
GO:0050760ISS-negative regulation of thymidylate synthase biosynthetic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
APLP2APBB11068198855266 10081969 Affinity Capture-Western; Reconstituted Complex
APLP2APBB11068318855266 10081969 Affinity Capture-Western; Reconstituted Complex
APPAPBB11068198855266 8887653 9045663 9837937 10081969 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APPAPBB11068488855266 8887653 9045663 9837937 10081969 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TFCP2APBB11068199685356 Affinity Capture-Western; Two-hybrid
TFCP2APBB11128829685356 Affinity Capture-Western; Two-hybrid
LRP1APBB11068199837937 Reconstituted Complex; Two-hybrid
LRP1APBB11102159837937 Reconstituted Complex; Two-hybrid
APLP1APBB110681910081969 Reconstituted Complex
APLP1APBB110683010081969 Reconstituted Complex
EVLAPBB111955610945997 16055720 Affinity Capture-MS; Reconstituted Complex
EVLAPBB110681910945997 16055720 Affinity Capture-MS; Reconstituted Complex
SETAPBB110681915592452 Affinity Capture-MS; Affinity Capture-Western
SETAPBB111231615592452 Affinity Capture-MS; Affinity Capture-Western
ABI1APBB111532416055720 Affinity Capture-MS
ABI1APBB110681916055720 Affinity Capture-MS
PQBP1APBB111539316055720 Affinity Capture-MS
PQBP1APBB110681916055720 Affinity Capture-MS
WASF2APBB111546516055720 Affinity Capture-MS
WASF2APBB110681916055720 Affinity Capture-MS
SF3B4APBB111555416055720 Affinity Capture-MS
SF3B4APBB110681916055720 Affinity Capture-MS
SF3A1APBB111558016055720 Affinity Capture-MS
SF3A1APBB110681916055720 Affinity Capture-MS
DDX17APBB111577616055720 Affinity Capture-MS
DDX17APBB110681916055720 Affinity Capture-MS
CHERPAPBB111577816055720 Affinity Capture-MS
CHERPAPBB110681916055720 Affinity Capture-MS
KHDRBS1APBB111590016055720 Affinity Capture-MS
KHDRBS1APBB110681916055720 Affinity Capture-MS
SF3A3APBB111614616055720 Affinity Capture-MS
SF3A3APBB110681916055720 Affinity Capture-MS
SF3B2APBB111618816055720 Affinity Capture-MS
SF3B2APBB110681916055720 Affinity Capture-MS
U2AF2APBB111646616055720 Affinity Capture-MS
U2AF2APBB110681916055720 Affinity Capture-MS
WIPF2APBB112704316055720 Affinity Capture-MS
WIPF2APBB110681916055720 Affinity Capture-MS
DDX3XAPBB110681916055720 Affinity Capture-MS
DDX3XAPBB110802016055720 Affinity Capture-MS
DHX9APBB110681916055720 Affinity Capture-MS
DHX9APBB110802516055720 Affinity Capture-MS
DHX15APBB110681916055720 Affinity Capture-MS
DHX15APBB110802916055720 Affinity Capture-MS
DIAPH1APBB110681916055720 Affinity Capture-MS
DIAPH1APBB110807316055720 Affinity Capture-MS
DIAPH2APBB110681916055720 Affinity Capture-MS
DIAPH2APBB110807416055720 Affinity Capture-MS
CYFIP1APBB111680016055720 Affinity Capture-MS
CYFIP1APBB110681916055720 Affinity Capture-MS
SF3B3APBB111701616055720 Affinity Capture-MS
SF3B3APBB110681916055720 Affinity Capture-MS
SF3B1APBB111701716055720 Affinity Capture-MS
SF3B1APBB110681916055720 Affinity Capture-MS
PABPC1APBB111793916055720 Affinity Capture-MS
PABPC1APBB110681916055720 Affinity Capture-MS
CYFIP2APBB111794516055720 Affinity Capture-MS
CYFIP2APBB110681916055720 Affinity Capture-MS
HTATSF1APBB111814916055720 Affinity Capture-MS
HTATSF1APBB110681916055720 Affinity Capture-MS
HNRNPH1APBB110681916055720 Affinity Capture-MS
HNRNPH1APBB110942816055720 Affinity Capture-MS
HNRNPKAPBB110681916055720 Affinity Capture-MS
HNRNPKAPBB110943116055720 Affinity Capture-MS
NONOAPBB110681916055720 Affinity Capture-MS
NONOAPBB111090416055720 Affinity Capture-MS
YBX1APBB110681916055720 Affinity Capture-MS
YBX1APBB111095916055720 Affinity Capture-MS
WBP11APBB111970216055720 Affinity Capture-MS
WBP11APBB110681916055720 Affinity Capture-MS
ENAHAPBB112085816055720 Affinity Capture-MS
ENAHAPBB110681916055720 Affinity Capture-MS
YLPM1APBB112111716055720 Affinity Capture-MS
YLPM1APBB110681916055720 Affinity Capture-MS
PTBP1APBB110681916055720 Affinity Capture-MS
PTBP1APBB111169716055720 Affinity Capture-MS
RPL4APBB111204416055720 Affinity Capture-MS
RPL4APBB110681916055720 Affinity Capture-MS
SFPQAPBB110681916055720 Affinity Capture-MS
SFPQAPBB111231916055720 Affinity Capture-MS
VASPAPBB111325116055720 Affinity Capture-MS
VASPAPBB110681916055720 Affinity Capture-MS
WASAPBB111329316055720 Affinity Capture-MS
WASAPBB110681916055720 Affinity Capture-MS
WIPF1APBB111329516055720 Affinity Capture-MS
WIPF1APBB110681916055720 Affinity Capture-MS
SF1APBB111336816055720 Affinity Capture-MS
SF1APBB110681916055720 Affinity Capture-MS
CPSF7APBB112295716055720 Affinity Capture-MS
CPSF7APBB110681916055720 Affinity Capture-MS
SF3A2APBB111382616055720 Affinity Capture-MS
SF3A2APBB110681916055720 Affinity Capture-MS
RBM17APBB112441616055720 Affinity Capture-MS
RBM17APBB110681916055720 Affinity Capture-MS
KHSRPAPBB111413916055720 Affinity Capture-MS
KHSRPAPBB110681916055720 Affinity Capture-MS
WASLAPBB111446616055720 Affinity Capture-MS
WASLAPBB110681916055720 Affinity Capture-MS
CCDC97APBB112469316055720 Affinity Capture-MS
CCDC97APBB110681916055720 Affinity Capture-MS
DDX46APBB111521016055720 Affinity Capture-MS
DDX46APBB110681916055720 Affinity Capture-MS
THRAP3APBB111529216055720 Affinity Capture-MS
THRAP3APBB110681916055720 Affinity Capture-MS
CPSF6APBB111623816055720 Affinity Capture-MS; Reconstituted Complex
CPSF6APBB110681916055720 Affinity Capture-MS; Reconstituted Complex
HDAC1APBB110681919343227 Affinity Capture-Western
HDAC1APBB110931519343227 Affinity Capture-Western
TSHZ3APBB112166319343227 Affinity Capture-Western; Reconstituted Complex
TSHZ3APBB110681919343227 Affinity Capture-Western; Reconstituted Complex
TSHZ1APBB111548919343227 Reconstituted Complex
TSHZ1APBB110681919343227 Reconstituted Complex
TSHZ2APBB112613119343227 Reconstituted Complex
TSHZ2APBB110681919343227 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APBB1rs1799755, rs1800606 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:107765
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018