AutismKB 2.0

Annotation Details for APC


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:APC ( BTPS2,DP2,DP2.5,DP3,GS )
Gene Full Name: adenomatous polyposis coli
Band: 5q22.2
Quick LinksEntrez ID:324; OMIM: 611731; Uniprot ID:APC_HUMAN; ENSEMBL ID: ENSG00000134982; HGNC ID: 583
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000776IDA-kinetochore11283619
GO:0005634IDA-nucleus11035805
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm11035805
GO:0005813IDA-centrosome11283619
GO:0005829TAS-cytosol-
GO:0005874IDAcolocalizes_withmicrotubule28057765
GO:0005886IDA-plasma membrane20937854
GO:0005886IDAcolocalizes_withplasma membrane16611247
GO:0005913IDAcolocalizes_withcell-cell adherens junction16611247
GO:0005923IDA-bicellular tight junction18502210
GO:0016328IDA-lateral plasma membrane12072559
GO:0016342IDA-catenin complex7806582
GO:0030027IDA-lamellipodium19151759
GO:0030877IDA-beta-catenin destruction complex8638126
GO:0032587IDA-ruffle membrane19151759
GO:0048471IDA-perinuclear region of cytoplasm18076571
GO:1990909NAS-Wnt signalosome24115276
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding8638126
GO:0008013IPI-beta-catenin binding7890674
GO:0008017IDA-microtubule binding11166179
GO:0019887IDA-protein kinase regulator activity11972058
GO:0019901IPI-protein kinase binding8638126
GO:0031625IDA-ubiquitin protein ligase binding18076571
GO:0042802IMP-identical protein binding28057765
GO:0045295IPI-gamma-catenin binding7890674
GO:0045296IDANOTcadherin binding7890674
GO:0051010IDA-microtubule plus-end binding19632184
GO:0070840IPI-dynein complex binding28057765
GO ID Evidence Qualifier GO_term References
GO:0000281IMP-mitotic cytokinesis17570218
GO:0006461IDA-protein complex assembly16188939
GO:0006974IDA-cellular response to DNA damage stimulus14728717
GO:0007026IDA-negative regulation of microtubule depolymerization11166179
GO:0007026IMP-negative regulation of microtubule depolymerization17192415
GO:0007050IDA-cell cycle arrest8521819
GO:0007094IMP-mitotic spindle assembly checkpoint17227893
GO:0007155NAS-cell adhesion8259518
GO:0008285IDA-negative regulation of cell proliferation8521819
GO:0008286IMP-insulin receptor signaling pathway28057765
GO:0010942IMP-positive regulation of cell death28057765
GO:0016055TAS-Wnt signaling pathway-
GO:0016477IMP-cell migration19151759
GO:0016579TAS-protein deubiquitination-
GO:0030335IMP-positive regulation of cell migration17192415
GO:0031274IMP-positive regulation of pseudopodium assembly17192415
GO:0032886IMP-regulation of microtubule-based process20937854
GO:0043065IMP-positive regulation of apoptotic process17227893
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0045732IC-positive regulation of protein catabolic process16188939
GO:0045732IGI-positive regulation of protein catabolic process12952940
GO:0045736IDA-negative regulation of cyclin-dependent protein serine/threonine kinase activity8521819
GO:0051260IMP-protein homooligomerization28057765
GO:0051988IMP-regulation of attachment of spindle microtubules to kinetochore17227893
GO:0051988NAS-regulation of attachment of spindle microtubules to kinetochore11283619
GO:0060070IC-canonical Wnt signaling pathway9601641
GO:0060070NAS-canonical Wnt signaling pathway11035805
GO:0070830NAS-bicellular tight junction assembly18502210
GO:0090090IGI-negative regulation of canonical Wnt signaling pathway12952940
GO:0090090NAS-negative regulation of canonical Wnt signaling pathway16344550
GO:0097194TAS-execution phase of apoptosis-
GO:1904781IMP-positive regulation of protein localization to centrosome28057765
GO:1904885TAS-beta-catenin destruction complex assembly-
GO:1904886TAS-beta-catenin destruction complex disassembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
APCACTN110660220936779 Two-hybrid
APCACTN110682120936779 Two-hybrid
APCAP2B110667220936779 Two-hybrid
APCAP2B110682120936779 Two-hybrid
APCANXA710680720936779 Two-hybrid
APCANXA710682120936779 Two-hybrid
MAPRE2APC1068217606712 11470413 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPRE2APC1161787606712 11470413 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUPAPC1068217651399 8074697 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUPAPC1099317651399 8074697 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CTNNA1APC1068217651399 8259519 20936779 Affinity Capture-Western; Two-hybrid
CTNNA1APC1078767651399 8259519 20936779 Affinity Capture-Western; Two-hybrid
CTNNB1APC1068218259519 9286858 11251183 11533658 11707392 11712088 11972058 12628243 15355978 16510874 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex
CTNNB1APC1078808259519 9286858 11251183 11533658 11707392 11712088 11972058 12628243 15355978 16510874 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex
APCAPC1068218389242 12070164 Affinity Capture-Western; Reconstituted Complex
DLG3APC1080859188857 Reconstituted Complex; Two-hybrid
DLG3APC1068219188857 Reconstituted Complex; Two-hybrid
DLGAP1APC1146609286858 Affinity Capture-Western
DLGAP1APC1068219286858 Affinity Capture-Western
MAD2L1APC1068219637688 Affinity Capture-Western
MAD2L1APC1102609637688 Affinity Capture-Western
AXIN1APC1139099734785 16199882 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1APC1068219734785 16199882 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGEF4APC11911410947987 Affinity Capture-Western; Reconstituted Complex
ARHGEF4APC10682110947987 Affinity Capture-Western; Reconstituted Complex
AXIN2APC11391010966653 Affinity Capture-Western
AXIN2APC10682110966653 Affinity Capture-Western
TUBA4AAPC11312811166179 Co-localization; Reconstituted Complex
TUBA4AAPC10682111166179 Co-localization; Reconstituted Complex
GSK3BAPC10682111251183 Affinity Capture-Western
GSK3BAPC10918711251183 Affinity Capture-Western
BUB3APC11462111283619 Affinity Capture-Western
BUB3APC10682111283619 Affinity Capture-Western
BUB1APC10716411283619 Affinity Capture-Western; Biochemical Activity
BUB1APC10682111283619 Affinity Capture-Western; Biochemical Activity
BUB1BAPC10682111283619 Biochemical Activity
BUB1BAPC10716611283619 Biochemical Activity
SIAH1APC11237211389840 Affinity Capture-Western; Reconstituted Complex
SIAH1APC10682111389840 Affinity Capture-Western; Reconstituted Complex
PPP2R5AAPC11151711585828 Co-localization
PPP2R5AAPC10682111585828 Co-localization
KIFAP3APC11658211912492 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KIFAP3APC10682111912492 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CSNK2BAPC10682111972058 Affinity Capture-Western
CSNK2BAPC10784311972058 Affinity Capture-Western
CSNK2A1APC10682111972058 Affinity Capture-Western; Reconstituted Complex
CSNK2A1APC10784111972058 Affinity Capture-Western; Reconstituted Complex
XPO1APC10682112070164 Affinity Capture-Western; Reconstituted Complex
XPO1APC11334812070164 Affinity Capture-Western; Reconstituted Complex
MAPRE1APC11658112388762 Reconstituted Complex
MAPRE1APC10682112388762 Reconstituted Complex
MUC1APC10682115020226 Affinity Capture-Western
MUC1APC11066915020226 Affinity Capture-Western
TFAP2AAPC11287815331612 Affinity Capture-Western; Reconstituted Complex
TFAP2AAPC10682115331612 Affinity Capture-Western; Reconstituted Complex
UBCAPC11316415355978 Affinity Capture-Western
UBCAPC10682115355978 Affinity Capture-Western
SFNAPC10682115778465 Affinity Capture-MS
SFNAPC10907215778465 Affinity Capture-MS
CTBP1APC10682116510875 Affinity Capture-Western
CTBP1APC10786916510875 Affinity Capture-Western
CSNK1A1APC10682119426738 Biochemical Activity
CSNK1A1APC10783619426738 Biochemical Activity
BTRCAPC11445719615732 Affinity Capture-MS
BTRCAPC10682119615732 Affinity Capture-MS
POM121CAPC10682120936779 Two-hybrid
POM121CAPC75583620936779 Two-hybrid
RANBP9APC11535920936779 Two-hybrid
RANBP9APC10682120936779 Two-hybrid
COG5APC11572920936779 Two-hybrid
COG5APC10682120936779 Two-hybrid
NUPL2APC10682120936779 Two-hybrid
NUPL2APC11627820936779 Two-hybrid
NOSTRINAPC10682120936779 Two-hybrid
NOSTRINAPC12544620936779 Two-hybrid
CREBBPAPC10682120936779 Two-hybrid
CREBBPAPC10777720936779 Two-hybrid
EPAS1APC10682120936779 Two-hybrid
EPAS1APC10834820936779 Two-hybrid
LPHN1APC10682120936779 Two-hybrid
LPHN1APC11652820936779 Two-hybrid
SEC31AAPC10682120936779 Two-hybrid
SEC31AAPC11653920936779 Two-hybrid
SNRNP200APC11666120936779 Two-hybrid
SNRNP200APC10682120936779 Two-hybrid
EXPH5APC11671520936779 Two-hybrid
EXPH5APC10682120936779 Two-hybrid
FLNAAPC10682120936779 Two-hybrid
FLNAAPC10860520936779 Two-hybrid
SYNE1APC11692820936779 Two-hybrid
SYNE1APC10682120936779 Two-hybrid
PPP1R13BAPC11694820936779 Two-hybrid
PPP1R13BAPC10682120936779 Two-hybrid
SPECC1LAPC11696020936779 Two-hybrid
SPECC1LAPC10682120936779 Two-hybrid
MACF1APC10682120936779 Two-hybrid
MACF1APC11704820936779 Two-hybrid
COG4APC10682120936779 Two-hybrid
COG4APC11736520936779 Two-hybrid
SFRS18APC10682120936779 Two-hybrid
SFRS18APC11744820936779 Two-hybrid
KRT23APC10682120936779 Two-hybrid
KRT23APC11746720936779 Two-hybrid
ANKRD17APC10682120936779 Two-hybrid
ANKRD17APC11751920936779 Two-hybrid
GIGYF2APC10682120936779 Two-hybrid
GIGYF2APC11752020936779 Two-hybrid
GOLGA2APC10682120936779 Two-hybrid
GOLGA2APC10906320936779 Two-hybrid
FHOD1APC10682120936779 Two-hybrid
FHOD1APC11887720936779 Two-hybrid
AGFG1APC10950320936779 Two-hybrid
AGFG1APC10682120936779 Two-hybrid
HSPA5APC10682120936779 Two-hybrid
HSPA5APC10954120936779 Two-hybrid
NCKAP5APC10682120936779 Two-hybrid
NCKAP5APC13128820936779 Two-hybrid
KIF5BAPC10682120936779 Two-hybrid
KIF5BAPC11000020936779 Two-hybrid
KRT5APC10682120936779 Two-hybrid
KRT5APC11005020936779 Two-hybrid
KRT13APC10682120936779 Two-hybrid
KRT13APC11005820936779 Two-hybrid
KRT14APC10682120936779 Two-hybrid
KRT14APC11005920936779 Two-hybrid
KRT15APC10682120936779 Two-hybrid
KRT15APC11006420936779 Two-hybrid
KRT17APC10682120936779 Two-hybrid
KRT17APC11007020936779 Two-hybrid
KRT19APC10682120936779 Two-hybrid
KRT19APC11007820936779 Two-hybrid
LAMA3APC10682120936779 Two-hybrid
LAMA3APC11010320936779 Two-hybrid
LAMA4APC11010420936779 Two-hybrid
LAMA4APC10682120936779 Two-hybrid
ND4APC10682120936779 Two-hybrid
ND4APC11063420936779 Two-hybrid
MYH10APC10682120936779 Two-hybrid
MYH10APC11071320936779 Two-hybrid
MYH11APC10682120936779 Two-hybrid
MYH11APC11071420936779 Two-hybrid
MYO6APC11073020936779 Two-hybrid
MYO6APC10682120936779 Two-hybrid
HNRNPMAPC11075120936779 Two-hybrid
HNRNPMAPC10682120936779 Two-hybrid
NEBAPC10682120936779 Two-hybrid
NEBAPC11078320936779 Two-hybrid
NUP98APC11098220936779 Two-hybrid
NUP98APC10682120936779 Two-hybrid
NUP54APC11975920936779 Two-hybrid
NUP54APC10682120936779 Two-hybrid
MBD5APC10682120936779 Two-hybrid
MBD5APC12089220936779 Two-hybrid
ERBB2IPAPC12099720936779 Two-hybrid
ERBB2IPAPC10682120936779 Two-hybrid
KIAA1370APC10682120936779 Two-hybrid
KIAA1370APC12110820936779 Two-hybrid
PSMD1APC10682120936779 Two-hybrid
PSMD1APC11168020936779 Two-hybrid
KIAA1328APC10682120936779 Two-hybrid
KIAA1328APC12159520936779 Two-hybrid
NCKAP5LAPC10682120936779 Two-hybrid
NCKAP5LAPC12172620936779 Two-hybrid
RANBP2APC11183920936779 Two-hybrid
RANBP2APC10682120936779 Two-hybrid
RPS27APC11214620936779 Two-hybrid
RPS27APC10682120936779 Two-hybrid
ZFP106APC10682120936779 Two-hybrid
ZFP106APC12215420936779 Two-hybrid
DSTAPC10713520936779 Two-hybrid
DSTAPC10682120936779 Two-hybrid
SPTBN1APC10682120936779 Two-hybrid
SPTBN1APC11258920936779 Two-hybrid
SPTBN2APC11259020936779 Two-hybrid
SPTBN2APC10682120936779 Two-hybrid
TRIM21APC10682120936779 Two-hybrid
TRIM21APC11261520936779 Two-hybrid
TAF1APC11273520936779 Two-hybrid
TAF1APC10682120936779 Two-hybrid
TPRAPC10682120936779 Two-hybrid
TPRAPC11302820936779 Two-hybrid
C4AAPC10682120936779 Two-hybrid
C4AAPC10718120936779 Two-hybrid
NUP214APC11371720936779 Two-hybrid
NUP214APC10682120936779 Two-hybrid
RBM4BAPC10682120936779 Two-hybrid
RBM4BAPC12376020936779 Two-hybrid
FBXO30APC10682120936779 Two-hybrid
FBXO30APC12387920936779 Two-hybrid
ING5APC12401620936779 Two-hybrid
ING5APC10682120936779 Two-hybrid
CGNL1APC10682120936779 Two-hybrid
CGNL1APC12438420936779 Two-hybrid
MCM3APAPC11440620936779 Two-hybrid
MCM3APAPC10682120936779 Two-hybrid
NAV3APC10682120936779 Two-hybrid
NAV3APC12460420936779 Two-hybrid
NAV1APC10682120936779 Two-hybrid
NAV1APC12460520936779 Two-hybrid
NAV2APC10682120936779 Two-hybrid
NAV2APC12460620936779 Two-hybrid
SMC3APC11457420936779 Two-hybrid
SMC3APC10682120936779 Two-hybrid
HGSAPC10682120936779 Two-hybrid
HGSAPC11459320936779 Two-hybrid
CYTH2APC11468720936779 Two-hybrid
CYTH2APC10682120936779 Two-hybrid
NUPL1APC10682120936779 Two-hybrid
NUPL1APC11515720936779 Two-hybrid
SETDB1APC11520220936779 Two-hybrid
SETDB1APC10682120936779 Two-hybrid
POM121APC10682120936779 Two-hybrid
POM121APC11521420936779 Two-hybrid
NUP153APC11529720936779 Two-hybrid
NUP153APC10682120936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
APCrs2229992, rs42427, rs465899 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88039
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031112-7'