Annotation Details for AIRE
Basic Information Top
| Gene Symbol: | AIRE ( AIRE1,APECED,APS1,APSI,PGA1 ) |
|---|---|
| Gene Full Name: | autoimmune regulator |
| Band: | 21q22.3 |
| Quick Links | Entrez ID:326; OMIM: 607358; Uniprot ID:AIRE_HUMAN; ENSEMBL ID: ENSG00000160224; HGNC ID: 360 |
| Relate to Another Database: | SFARIGene; denovo-db |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0005634 | IBA | - | nucleus | - |
| GO:0005634 | NAS | - | nucleus | 9398840 |
| GO:0005737 | IEA | - | cytoplasm | - |
| GO:0016604 | ISS | - | nuclear body | - |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0000977 | IDA | - | RNA polymerase II regulatory region sequence-specific DNA binding | 11533054 |
| GO:0001228 | IC | - | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | - |
| GO:0003682 | IDA | - | chromatin binding | 18292755 |
| GO:0003712 | IBA | - | transcription cofactor activity | - |
| GO:0005515 | IPI | - | protein binding | 17474147 |
| GO:0008270 | IDA | - | zinc ion binding | 19446523 |
| GO:0042393 | IDA | - | histone binding | 18292755 |
| GO:0042802 | IEA | - | identical protein binding | - |
| GO:0044212 | IDA | - | transcription regulatory region DNA binding | 18292755 |
| GO:0045182 | IEA | - | translation regulator activity | - |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0002458 | ISS | - | peripheral T cell tolerance induction | - |
| GO:0002509 | IMP | - | central tolerance induction to self antigen | 26084028 |
| GO:0006355 | IDA | - | regulation of transcription, DNA-templated | 18292755 |
| GO:0006366 | IEA | - | transcription from RNA polymerase II promoter | - |
| GO:0006417 | IEA | - | regulation of translation | - |
| GO:0006955 | TAS | - | immune response | 9398840 |
| GO:0006959 | IEA | - | humoral immune response | - |
| GO:0032602 | ISS | - | chemokine production | - |
| GO:0045060 | IEA | - | negative thymic T cell selection | - |
| GO:0045893 | IDA | - | positive regulation of transcription, DNA-templated | 18292755 |
| GO:0045893 | IMP | - | positive regulation of transcription, DNA-templated | 26084028 |
| GO:0045944 | IMP | - | positive regulation of transcription from RNA polymerase II promoter | 11274163 |
| GO:0097536 | ISS | - | thymus epithelium morphogenesis | - |
| GO:2000410 | ISS | - | regulation of thymocyte migration | - |
| Gene Symbol | Interactant | Interaction ID | References | Description |
|---|---|---|---|---|
| AIRE | PARP1 | 106823 | 20085707 | Affinity Capture-MS |
| AIRE | PARP1 | 106652 | 20085707 | Affinity Capture-MS |
| CREBBP | AIRE | 106823 | 10748110 12929931 | Far Western; Two-hybrid |
| CREBBP | AIRE | 107777 | 10748110 12929931 | Far Western; Two-hybrid |
| AIRE | AIRE | 106823 | 10748110 12929931 | Reconstituted Complex; Two-hybrid |
| HSPA4 | AIRE | 106823 | 15150263 | Affinity Capture-MS |
| HSPA4 | AIRE | 109540 | 15150263 | Affinity Capture-MS |
| HSPA5 | AIRE | 106823 | 15150263 | Affinity Capture-MS |
| HSPA5 | AIRE | 109541 | 15150263 | Affinity Capture-MS |
| RANBP9 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| RANBP9 | AIRE | 115359 | 20085707 | Affinity Capture-MS |
| DDX17 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| DDX17 | AIRE | 115776 | 20085707 | Affinity Capture-MS |
| IPO7 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| IPO7 | AIRE | 115782 | 20085707 | Affinity Capture-MS |
| NOP56 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| NOP56 | AIRE | 115783 | 20085707 | Affinity Capture-MS |
| RUVBL2 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| RUVBL2 | AIRE | 116067 | 20085707 | Affinity Capture-MS |
| XPOT | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| XPOT | AIRE | 116420 | 20085707 | Affinity Capture-MS |
| GEMIN5 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| GEMIN5 | AIRE | 117429 | 20085707 | Affinity Capture-MS |
| PABPC1 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| PABPC1 | AIRE | 117939 | 20085707 | Affinity Capture-MS |
| MSH6 | AIRE | 109211 | 20085707 | Affinity Capture-MS |
| MSH6 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| KPNB1 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| KPNB1 | AIRE | 110035 | 20085707 | Affinity Capture-MS |
| MCM2 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| MCM2 | AIRE | 110339 | 20085707 | Affinity Capture-MS |
| MCM5 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| MCM5 | AIRE | 110342 | 20085707 | Affinity Capture-MS |
| MCM6 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| MCM6 | AIRE | 110343 | 20085707 | Affinity Capture-MS |
| MSH2 | AIRE | 110573 | 20085707 | Affinity Capture-MS |
| MSH2 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| PCNA | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| PCNA | AIRE | 111142 | 20085707 | Affinity Capture-MS |
| POLR2A | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| POLR2A | AIRE | 111426 | 20085707 | Affinity Capture-MS |
| POLR2B | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| POLR2B | AIRE | 111427 | 20085707 | Affinity Capture-MS |
| RANBP2 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| RANBP2 | AIRE | 111839 | 20085707 | Affinity Capture-MS |
| SRSF1 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| SRSF1 | AIRE | 112324 | 20085707 | Affinity Capture-MS |
| SRSF3 | AIRE | 112326 | 20085707 | Affinity Capture-MS |
| SRSF3 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| SNRPB | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| SNRPB | AIRE | 112512 | 20085707 | Affinity Capture-MS |
| SNRPD3 | AIRE | 112518 | 20085707 | Affinity Capture-MS |
| SNRPD3 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| XPO1 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| XPO1 | AIRE | 113348 | 20085707 | Affinity Capture-MS |
| HIST1H2AC | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| HIST1H2AC | AIRE | 113930 | 20085707 | Affinity Capture-MS |
| HIST1H2BO | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| HIST1H2BO | AIRE | 113944 | 20085707 | Affinity Capture-MS |
| CHD6 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| CHD6 | AIRE | 123931 | 20085707 | Affinity Capture-MS |
| SMC3 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| SMC3 | AIRE | 114574 | 20085707 | Affinity Capture-MS |
| EFTUD2 | AIRE | 106823 | 20085707 | Affinity Capture-MS |
| EFTUD2 | AIRE | 114749 | 20085707 | Affinity Capture-MS |
| TRIM28 | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| TRIM28 | AIRE | 115457 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| MYBBP1A | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| MYBBP1A | AIRE | 115770 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| DDX5 | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| DDX5 | AIRE | 108021 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| LMNB1 | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| LMNB1 | AIRE | 110187 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| NASP | AIRE | 110759 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| NASP | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| PRKDC | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| PRKDC | AIRE | 111577 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| RAD21 | AIRE | 111822 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| RAD21 | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| SRSF2 | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| SRSF2 | AIRE | 112325 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| SSRP1 | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| SSRP1 | AIRE | 112627 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| TOP2A | AIRE | 113006 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| TOP2A | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| SMC1A | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| SMC1A | AIRE | 113871 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| NUP93 | AIRE | 106823 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| NUP93 | AIRE | 115041 | 20085707 | Affinity Capture-MS; Affinity Capture-Western |
| No data |
| No data |
- MGI ID: MGI:1338803
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-071008-4



AlzGene, PDGene and SZGene