AutismKB 2.0

Annotation Details for HRAS


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Basic Information Top
Gene Symbol:HRAS ( C-BAS/HAS,C-H-RAS,C-HA-RAS1,CTLO,H-RASIDX,HAMSV,HRAS1,K-RAS,N-RAS,RASH1 )
Gene Full Name: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Band: 11p15.5
Quick LinksEntrez ID:3265; OMIM: 190020; Uniprot ID:RASH_HUMAN; ENSEMBL ID: ENSG00000174775; HGNC ID: 5173
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005634IEA-nucleus-
GO:0005737TAS-cytoplasm10842192
GO:0005794IDA-Golgi apparatus14500341
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane14500341
GO:0005886TAS-plasma membrane-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0003924IDA-GTPase activity9178006
GO:0003924IMP-GTPase activity9230043
GO:0005515IPI-protein binding2122974
GO:0005525IDA-GTP binding14500341
GO:0005525IMP-GTP binding9230043
GO:0008022IPI-protein C-terminus binding9219684
GO:0019003IMP-GDP binding8142349
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001934IDA-positive regulation of protein phosphorylation22065586
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006897IEA-endocytosis-
GO:0006935TAS-chemotaxis10848592
GO:0007050IDA-cell cycle arrest9054499
GO:0007050IMP-cell cycle arrest9765203
GO:0007093IDA-mitotic cell cycle checkpoint9054499
GO:0007165NAS-signal transduction8607982
GO:0007166TAS-cell surface receptor signaling pathway9020890
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007265IDA-Ras protein signal transduction23027131
GO:0007265TAS-Ras protein signal transduction-
GO:0007411TAS-axon guidance-
GO:0008283IEA-cell proliferation-
GO:0008284IDA-positive regulation of cell proliferation9765203
GO:0008285IDA-negative regulation of cell proliferation9054499
GO:0009887TAS-animal organ morphogenesis10848592
GO:0010629IDA-negative regulation of gene expression23027131
GO:0030335IDA-positive regulation of cell migration23027131
GO:0032729IEA-positive regulation of interferon-gamma production-
GO:0034260IDA-negative regulation of GTPase activity23027131
GO:0035900IEA-response to isolation stress-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0042088IEA-T-helper 1 type immune response-
GO:0042832IEA-defense response to protozoan-
GO:0043406IDA-positive regulation of MAP kinase activity23027131
GO:0043410IDA-positive regulation of MAPK cascade9765203
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043547IDA-positive regulation of GTPase activity23027131
GO:0045740IDA-positive regulation of DNA replication9765203
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter22065586
GO:0046330IDA-positive regulation of JNK cascade22065586
GO:0046579IEA-positive regulation of Ras protein signal transduction-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048169IEA-regulation of long-term neuronal synaptic plasticity-
GO:0050679IMP-positive regulation of epithelial cell proliferation20154697
GO:0050852IEA-T cell receptor signaling pathway-
GO:0050900TAS-leukocyte migration-
GO:0051291IEA-protein heterooligomerization-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade22065586
GO:0071480IDA-cellular response to gamma radiation16213212
GO:0090303IDA-positive regulation of wound healing23027131
GO:0090398IDA-cellular senescence9054499
GO:0097193IEA-intrinsic apoptotic signaling pathway-
GO:1900029IDA-positive regulation of ruffle assembly23027131
GO:2000251IDA-positive regulation of actin cytoskeleton reorganization23027131
GO:2000630IDA-positive regulation of miRNA metabolic process23027131
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HRASBRAF1095017706312 9154803 Reconstituted Complex; Two-hybrid
HRASBRAF1071417706312 9154803 Reconstituted Complex; Two-hybrid
INSRHRAS1095013109943 Biochemical Activity
INSRHRAS1098543109943 Biochemical Activity
RASA1HRAS1095017628625 9219684 11389730 Biochemical Activity; Co-crystal Structure; Reconstituted Complex
RASA1HRAS1118567628625 9219684 11389730 Biochemical Activity; Co-crystal Structure; Reconstituted Complex
RALGDSHRAS1095017809086 7972015 9038168 9150145 9154803 10783161 10922060 15031288 20936779 Reconstituted Complex; Two-hybrid
RALGDSHRAS1118367809086 7972015 9038168 9150145 9154803 10783161 10922060 15031288 20936779 Reconstituted Complex; Two-hybrid
RAF1HRAS1118317862125 7969158 8530446 8628317 9150145 9154803 9523700 10369681 10783161 10882715 10922060 12379659 12620389 14654780 14724584 15031288 16803888 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1HRAS1095017862125 7969158 8530446 8628317 9150145 9154803 9523700 10369681 10783161 10882715 10922060 12379659 12620389 14654780 14724584 15031288 16803888 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RIN1HRAS1095017862125 15031288 Reconstituted Complex; Two-hybrid
RIN1HRAS1149727862125 15031288 Reconstituted Complex; Two-hybrid
MAP2K1HRAS1095017969158 Affinity Capture-Western
MAP2K1HRAS1115907969158 Affinity Capture-Western
NF1HRAS1095018628317 Two-hybrid
NF1HRAS1108368628317 Two-hybrid
PIK3CAHRAS1095018665852 10783161 14724584 Reconstituted Complex; Two-hybrid
PIK3CAHRAS1113088665852 10783161 14724584 Reconstituted Complex; Two-hybrid
RGL2HRAS1095018939933 15031288 20936779 Reconstituted Complex; Two-hybrid
RGL2HRAS1118018939933 15031288 20936779 Reconstituted Complex; Two-hybrid
PIK3R1HRAS1095019150145 10212255 Affinity Capture-Western; Reconstituted Complex
PIK3R1HRAS1113139150145 10212255 Affinity Capture-Western; Reconstituted Complex
RGL4HRAS1095019154803 12874025 Reconstituted Complex; Two-hybrid
RGL4HRAS1293369154803 12874025 Reconstituted Complex; Two-hybrid
RASGRF1HRAS1095019154803 Two-hybrid
RASGRF1HRAS1118589154803 Two-hybrid
SNRPEHRAS1125199154803 Two-hybrid
SNRPEHRAS1095019154803 Two-hybrid
RASSF5HRAS1095019488663 Reconstituted Complex
RASSF5HRAS1236899488663 Reconstituted Complex
SOS1HRAS1125379690470 12628188 Co-crystal Structure
SOS1HRAS1095019690470 12628188 Co-crystal Structure
MLLT4HRAS10950110334923 10922060 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MLLT4HRAS11044710334923 10922060 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IKZF3HRAS10950110369681 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IKZF3HRAS11648410369681 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PLAUHRAS10950110402467 Phenotypic Suppression
PLAUHRAS11134410402467 Phenotypic Suppression
SHOC2HRAS10950110783161 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHOC2HRAS11372910783161 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIK3CDHRAS10950110922060 Two-hybrid
PIK3CDHRAS11131110922060 Two-hybrid
RASSF1HRAS10950110998413 Affinity Capture-Western; Reconstituted Complex
RASSF1HRAS11635610998413 Affinity Capture-Western; Reconstituted Complex
PIK3CGHRAS10950111136978 Co-crystal Structure
PIK3CGHRAS11131211136978 Co-crystal Structure
DGKZHRAS10950111257115 Affinity Capture-Western
DGKZHRAS11409511257115 Affinity Capture-Western
LGALS1HRAS10950111709720 Affinity Capture-MS; Affinity Capture-Western
LGALS1HRAS11014711709720 Affinity Capture-MS; Affinity Capture-Western
PDE6DHRAS11117311786539 11980706 Two-hybrid
PDE6DHRAS10950111786539 11980706 Two-hybrid
RALAHRAS10950111786539 Two-hybrid
RALAHRAS11183411786539 Two-hybrid
RAP1GDS1HRAS10950111948427 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAP1GDS1HRAS11184511948427 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TIAM1HRAS10950112134164 Affinity Capture-Western
TIAM1HRAS11293012134164 Affinity Capture-Western
ERBB2IPHRAS10950112379659 Affinity Capture-Western
ERBB2IPHRAS12099712379659 Affinity Capture-Western
ARHGEF1HRAS10950112581858 Biochemical Activity
ARHGEF1HRAS11458512581858 Biochemical Activity
GPSM2HRAS10950112748287 Affinity Capture-Western
GPSM2HRAS11894912748287 Affinity Capture-Western
TTC1HRAS10950112748287 Affinity Capture-Western
TTC1HRAS11311612748287 Affinity Capture-Western
RASIP1HRAS10950115031288 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RASIP1HRAS12026315031288 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RHEBHRAS10950115854902 Affinity Capture-Western
RHEBHRAS11194115854902 Affinity Capture-Western
ZHX2HRAS10950117533377 Two-hybrid
ZHX2HRAS11654917533377 Two-hybrid
RGL1HRAS10950120936779 Two-hybrid
RGL1HRAS11679120936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
RAF1HRAS21869115705808 Hras interacts with Raf. This interaction was modelled on a demonstrated interaction between Hras and Raf, both from an unspecified species.
RALGDSHRAS1853049516482 Ras interacts with the carboxy terminus of RalGDS. This interaction was modeled on a demonstrated interaction between human Ras and rat RalGDS.
APBB1IPHRAS18549615469846 RIAM interacts with Ras.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96224
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050417-95'