AutismKB 2.0

Annotation Details for APEX1


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Basic Information Top
Gene Symbol:APEX1 ( APE,APE1,APEN,APEX,APX,HAP1,REF1 )
Gene Full Name: APEX nuclease (multifunctional DNA repair enzyme) 1
Band: 14q11.2
Quick LinksEntrez ID:328; OMIM: 107748; Uniprot ID:APEX1_HUMAN; ENSEMBL ID: ENSG00000100823; HGNC ID: 587
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IC-nuclear chromosome, telomeric region24703901
GO:0005634IDA-nucleus9119221
GO:0005654IDA-nucleoplasm17148573
GO:0005654TAS-nucleoplasm-
GO:0005667IEA-transcription factor complex-
GO:0005730IDA-nucleolus17148573
GO:0005737IDA-cytoplasm9560228
GO:0005739IDA-mitochondrion20231292
GO:0005783TAS-endoplasmic reticulum12524539
GO:0005813IDA-centrosome-
GO:0005840TAS-ribosome12524539
GO:0016607IDA-nuclear speck17148573
GO:0048471IDA-perinuclear region of cytoplasm12524539
GO ID Evidence Qualifier GO_term References
GO:0003677IDA-DNA binding11286553
GO:0003684IDA-damaged DNA binding12524539
GO:0003691IDA-double-stranded telomeric DNA binding24703901
GO:0003713IDA-transcription coactivator activity9119221
GO:0003714TAS-transcription corepressor activity7961715
GO:0003723IDA-RNA binding22681889
GO:0003906IDA-DNA-(apurinic or apyrimidinic site) lyase activity8932386
GO:0003906TAS-DNA-(apurinic or apyrimidinic site) lyase activity9119221
GO:0004519IDA-endonuclease activity11478795
GO:0004520TAS-endodeoxyribonuclease activity-
GO:0004523TAS-RNA-DNA hybrid ribonuclease activity11286553
GO:0004528TAS-phosphodiesterase I activity9119221
GO:0004844TAS-uracil DNA N-glycosylase activity10805771
GO:0005515IPI-protein binding8621488
GO:0008081IDA-phosphoric diester hydrolase activity11478795
GO:0008309IDA-double-stranded DNA exodeoxyribonuclease activity24703901
GO:0008311IBA-double-stranded DNA 3'-5' exodeoxyribonuclease activity-
GO:0008408IDA-3'-5' exonuclease activity11832948
GO:0008408TAS-3'-5' exonuclease activity11286553
GO:0016491IDA-oxidoreductase activity9119221
GO:0016890IDA-site-specific endodeoxyribonuclease activity, specific for altered base19188445
GO:0031490IDA-chromatin DNA binding11809897
GO:0032403IEA-protein complex binding-
GO:0046872IDA-metal ion binding11286553
GO:0051059IEA-NF-kappaB binding-
GO ID Evidence Qualifier GO_term References
GO:0000723IDA-telomere maintenance24703901
GO:0006281IDA-DNA repair9560228
GO:0006284IDA-base-excision repair8932386
GO:0006284TAS-base-excision repair-
GO:0006286TAS-base-excision repair, base-free sugar-phosphate removal-
GO:0006310IEA-DNA recombination-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0007568IEA-aging-
GO:0014912IEA-negative regulation of smooth muscle cell migration-
GO:0042493IEA-response to drug-
GO:0043488IMP-regulation of mRNA stability19401441
GO:0045454IEA-cell redox homeostasis-
GO:0045739IDA-positive regulation of DNA repair9207062
GO:0055114IEA-oxidation-reduction process-
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0071320IEA-cellular response to cAMP-
GO:0071375IEA-cellular response to peptide hormone stimulus-
GO:0080111IDA-DNA demethylation21496894
GO:0090502IEA-RNA phosphodiester bond hydrolysis, endonucleolytic-
GO:1900087IEA-positive regulation of G1/S transition of mitotic cell cycle-
GO:1903507IEA-negative regulation of nucleic acid-templated transcription-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
XRCC5APEX11068258621488 Reconstituted Complex
XRCC5APEX11133538621488 Reconstituted Complex
TP53APEX11130109119221 Co-purification
TP53APEX11068259119221 Co-purification
HIF1AAPEX110682510594042 Reconstituted Complex
HIF1AAPEX110933810594042 Reconstituted Complex
MUTYHAPEX111068111092888 Affinity Capture-Western; Reconstituted Complex
MUTYHAPEX110682511092888 Affinity Capture-Western; Reconstituted Complex
FEN1APEX110682511601988 Affinity Capture-Western; Reconstituted Complex
FEN1APEX110852811601988 Affinity Capture-Western; Reconstituted Complex
PCNAAPEX110682511601988 Reconstituted Complex
PCNAAPEX111114211601988 Reconstituted Complex
XRCC1APEX110682511707423 Far Western; Two-hybrid
XRCC1APEX111334911707423 Far Western; Two-hybrid
HNRNPLAPEX110682511809897 Reconstituted Complex
HNRNPLAPEX110943211809897 Reconstituted Complex
SETAPEX110682512524539 Affinity Capture-Western
SETAPEX111231612524539 Affinity Capture-Western
ANP32AAPEX111379112524539 Affinity Capture-Western
ANP32AAPEX110682512524539 Affinity Capture-Western
HOXC13APEX110682520211142 Two-hybrid
HOXC13APEX110946920211142 Two-hybrid
POLR3DAPEX110682520211142 Two-hybrid
POLR3DAPEX110712920211142 Two-hybrid
TCF21APEX110682520211142 Two-hybrid
TCF21APEX111280320211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APEX1rs1130409 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:88042
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2761'