AutismKB 2.0

Annotation Details for HES1


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Basic Information Top
Gene Symbol:HES1 ( FLJ20408,HES-1,HHL,HRY,bHLHb39 )
Gene Full Name: hairy and enhancer of split 1, (Drosophila)
Band: 3q29
Quick LinksEntrez ID:3280; OMIM: 139605; Uniprot ID:HES1_HUMAN; ENSEMBL ID: ENSG00000114315; HGNC ID: 5192
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IEA-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0001078ISS-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003677TAS-DNA binding7906273
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding17681138
GO:0005515IPI-protein binding12535671
GO:0008134NAS-transcription factor binding17611704
GO:0042803ISS-protein homodimerization activity-
GO:0042826IPI-histone deacetylase binding12535671
GO:0043565ISS-sequence-specific DNA binding-
GO:0051087IEA-chaperone binding-
GO:0071820ISS-N-box binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter12032823
GO:0001889IEA-liver development-
GO:0003143ISS-embryonic heart tube morphogenesis-
GO:0003151ISS-outflow tract morphogenesis-
GO:0003266IEA-regulation of secondary heart field cardioblast proliferation-
GO:0003281ISS-ventricular septum development-
GO:0006351IEA-transcription, DNA-templated-
GO:0006461ISS-protein complex assembly-
GO:0007155IEA-cell adhesion-
GO:0007219IDA-Notch signaling pathway16160079
GO:0007219IMP-Notch signaling pathway19682396
GO:0007224IEA-smoothened signaling pathway-
GO:0007262ISS-STAT protein import into nucleus-
GO:0007399TAS-nervous system development8020957
GO:0008284ISS-positive regulation of cell proliferation-
GO:0016477IEA-cell migration-
GO:0021537IEA-telencephalon development-
GO:0021555IEA-midbrain-hindbrain boundary morphogenesis-
GO:0021557IEA-oculomotor nerve development-
GO:0021558IEA-trochlear nerve development-
GO:0021575IEA-hindbrain morphogenesis-
GO:0021861ISS-forebrain radial glial cell differentiation-
GO:0021984IEA-adenohypophysis development-
GO:0030324IEA-lung development-
GO:0030513IEA-positive regulation of BMP signaling pathway-
GO:0030901IEA-midbrain development-
GO:0031016IEA-pancreas development-
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035910ISS-ascending aorta morphogenesis-
GO:0042102IEA-positive regulation of T cell proliferation-
GO:0042531ISS-positive regulation of tyrosine phosphorylation of STAT protein-
GO:0042668IEA-auditory receptor cell fate determination-
GO:0043388ISS-positive regulation of DNA binding-
GO:0045598IEA-regulation of fat cell differentiation-
GO:0045608IEA-negative regulation of auditory receptor cell differentiation-
GO:0045747IEA-positive regulation of Notch signaling pathway-
GO:0045892IDA-negative regulation of transcription, DNA-templated12535671
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0045977ISS-positive regulation of mitotic cell cycle, embryonic-
GO:0046331IEA-lateral inhibition-
GO:0046427ISS-positive regulation of JAK-STAT cascade-
GO:0048469IEA-cell maturation-
GO:0048538ISS-thymus development-
GO:0048667IEA-cell morphogenesis involved in neuron differentiation-
GO:0048711ISS-positive regulation of astrocyte differentiation-
GO:0048715ISS-negative regulation of oligodendrocyte differentiation-
GO:0048844ISS-artery morphogenesis-
GO:0050678IEA-regulation of epithelial cell proliferation-
GO:0060122IEA-inner ear receptor stereocilium organization-
GO:0060164IEA-regulation of timing of neuron differentiation-
GO:0060253ISS-negative regulation of glial cell proliferation-
GO:0060412ISS-ventricular septum morphogenesis-
GO:0060675IEA-ureteric bud morphogenesis-
GO:0060716IEA-labyrinthine layer blood vessel development-
GO:0061009IEA-common bile duct development-
GO:0061106IEA-negative regulation of stomach neuroendocrine cell differentiation-
GO:0061309IEA-cardiac neural crest cell development involved in outflow tract morphogenesis-
GO:0061626ISS-pharyngeal arch artery morphogenesis-
GO:0072012IEA-glomerulus vasculature development-
GO:0072049IEA-comma-shaped body morphogenesis-
GO:0072050IEA-S-shaped body morphogenesis-
GO:0072141IEA-renal interstitial fibroblast development-
GO:0072282IEA-metanephric nephron tubule morphogenesis-
GO:0090102IEA-cochlea development-
GO:0090162IEA-establishment of epithelial cell polarity-
GO:0097084ISS-vascular smooth muscle cell development-
GO:0097150IEP-neuronal stem cell population maintenance19682396
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24270810
GO:2000227IEA-negative regulation of pancreatic A cell differentiation-
GO:2000737IMP-negative regulation of stem cell differentiation19682396
GO:2000974IMP-negative regulation of pro-B cell differentiation12032823
GO:2000978ISS-negative regulation of forebrain neuron differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HES1RUNX210730816195230 Affinity Capture-Western; Co-localization
HES1RUNX210951416195230 Affinity Capture-Western; Co-localization
HES1HDAC110951416195230 Affinity Capture-Western
HES1HDAC110931516195230 Affinity Capture-Western
TLE2HES11129449874198 Reconstituted Complex; Two-hybrid
TLE2HES11095149874198 Reconstituted Complex; Two-hybrid
HEY2HES111704511486045 Reconstituted Complex
HEY2HES110951411486045 Reconstituted Complex
SIRT1HES111698312535671 Affinity Capture-Western; Reconstituted Complex
SIRT1HES110951412535671 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104853
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-144'