AutismKB 2.0

Annotation Details for BIRC2


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Basic Information Top
Gene Symbol:BIRC2 ( API1,HIAP2,Hiap-2,MIHB,RNF48,c-IAP1,cIAP1 )
Gene Full Name: baculoviral IAP repeat-containing 2
Band: 11q22.2
Quick LinksEntrez ID:329; OMIM: 601712; Uniprot ID:BIRC2_HUMAN; ENSEMBL ID: ENSG00000110330; HGNC ID: 590
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001741IEA-XY body-
GO:0005634IDA-nucleus15665297
GO:0005737IDA-cytoplasm16510124
GO:0005829TAS-cytosol-
GO:0009898ISS-cytoplasmic side of plasma membrane-
GO:0035631ISS-CD40 receptor complex-
GO:0043234IEA-protein complex-
GO:0045121IEA-membrane raft-
GO ID Evidence Qualifier GO_term References
GO:0003713IMP-transcription coactivator activity21653699
GO:0004842EXP-ubiquitin-protein transferase activity10797013
GO:0004842IDA-ubiquitin-protein transferase activity11907583
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11084335
GO:0008270IDA-zinc ion binding19153467
GO:0016740EXP-transferase activity19008929
GO:0043027IBA-cysteine-type endopeptidase inhibitor activity involved in apoptotic process-
GO:0043130IDA-ubiquitin binding16510124
GO:0047485IPI-protein N-terminus binding19153467
GO:0051087IPI-chaperone binding18239673
GO:0098770IPI-FBXO family protein binding16510124
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination11907583
GO:0001666IEA-response to hypoxia-
GO:0001890IEA-placenta development-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0007166TAS-cell surface receptor signaling pathway8548810
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0010803TAS-regulation of tumor necrosis factor-mediated signaling pathway-
GO:0016579TAS-protein deubiquitination-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0034121TAS-regulation of toll-like receptor signaling pathway20888210
GO:0035666TAS-TRIF-dependent toll-like receptor signaling pathway-
GO:0038061TAS-NIK/NF-kappaB signaling20651737
GO:0039535TAS-regulation of RIG-I signaling pathway20888210
GO:0042127TAS-regulation of cell proliferation18414036
GO:0042981IMP-regulation of apoptotic process21737330
GO:0043066IDA-negative regulation of apoptotic process21525013
GO:0043066TAS-negative regulation of apoptotic process20651737
GO:0043123IEP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process11907583
GO:0045088TAS-regulation of innate immune response21447281
GO:0045471IEA-response to ethanol-
GO:0045595TAS-regulation of cell differentiation18414036
GO:0050727TAS-regulation of inflammatory response21447281
GO:0051291IEA-protein heterooligomerization-
GO:0051591IEA-response to cAMP-
GO:0051726IDA-regulation of cell cycle15665297
GO:0060544IMP-regulation of necroptotic process21737330
GO:0060544TAS-regulation of necroptotic process-
GO:0060546IBA-negative regulation of necroptotic process-
GO:0070266IEA-necroptotic process-
GO:0070424TAS-regulation of nucleotide-binding oligomerization domain containing signaling pathway20888210
GO:0090307IBANOTmitotic spindle assembly-
GO:0097194TAS-execution phase of apoptosis-
GO:1901222IEA-regulation of NIK/NF-kappaB signaling-
GO:1902443IEA-negative regulation of ripoptosome assembly involved in necroptotic process-
GO:1902523IDA-positive regulation of protein K63-linked ubiquitination21931591
GO:1902524IDA-positive regulation of protein K48-linked ubiquitination21931591
GO:1902527IDA-positive regulation of protein monoubiquitination21931591
GO:1990001IBA-inhibition of cysteine-type endopeptidase activity involved in apoptotic process-
GO:2000116TAS-regulation of cysteine-type endopeptidase activity20651737
GO:2000377IEA-regulation of reactive oxygen species metabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRAF2BIRC21130388643514 8943045 9384571 10753917 11907583 15861135 16189514 16263936 16282325 20562859 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
TRAF2BIRC21068268643514 8943045 9384571 10753917 11907583 15861135 16189514 16263936 16282325 20562859 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
TNFRSF1ABIRC21129868943045 Affinity Capture-Western
TNFRSF1ABIRC21068268943045 Affinity Capture-Western
TRAF1BIRC21068268943045 9384571 11907583 Affinity Capture-Western; Reconstituted Complex
TRAF1BIRC21130378943045 9384571 11907583 Affinity Capture-Western; Reconstituted Complex
CASP3BIRC21068269384571 Reconstituted Complex
CASP3BIRC21072869384571 Reconstituted Complex
CASP7BIRC21068269384571 Reconstituted Complex
CASP7BIRC21072909384571 Reconstituted Complex
CASP9BIRC21068269545235 Affinity Capture-Western; Reconstituted Complex
CASP9BIRC21072929545235 Affinity Capture-Western; Reconstituted Complex
RIPK2BIRC21143009642260 9705938 Affinity Capture-Western
RIPK2BIRC21068269642260 9705938 Affinity Capture-Western
BCL10BIRC210682610753917 16775419 Affinity Capture-Western
BCL10BIRC211442910753917 16775419 Affinity Capture-Western
DIABLOBIRC210682610929712 12525502 12865429 14960576 16282325 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DIABLOBIRC212115710929712 12525502 12865429 14960576 16282325 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HTRA2BIRC211816511604410 12865429 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
HTRA2BIRC210682611604410 12865429 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BIRC2BIRC210682611907583 Biochemical Activity
UBCBIRC211316412525502 16510124 18230607 18239673 18570872 Affinity Capture-Western
UBCBIRC210682612525502 16510124 18230607 18239673 18570872 Affinity Capture-Western
UBE2D1BIRC210682612525502 Affinity Capture-Western
UBE2D1BIRC211316912525502 Affinity Capture-Western
UBE2D3BIRC210682612525502 Affinity Capture-Western
UBE2D3BIRC211317112525502 Affinity Capture-Western
UBE2L3BIRC210682612525502 Affinity Capture-Western
UBE2L3BIRC211318012525502 Affinity Capture-Western
TNFSF14BIRC211427712571250 Affinity Capture-MS; Affinity Capture-Western
TNFSF14BIRC210682612571250 Affinity Capture-MS; Affinity Capture-Western
GSPT1BIRC210919012865429 Affinity Capture-MS; Reconstituted Complex
GSPT1BIRC210682612865429 Affinity Capture-MS; Reconstituted Complex
IKBKGBIRC210682612867425 Affinity Capture-Western
IKBKGBIRC211408912867425 Affinity Capture-Western
CASP8BIRC210682612887920 Affinity Capture-Western
CASP8BIRC210729112887920 Affinity Capture-Western
BIRC5BIRC210682615218035 Reconstituted Complex
BIRC5BIRC210682915218035 Reconstituted Complex
UBE2J1BIRC210682615861135 19690564 Reconstituted Complex; Two-hybrid
UBE2J1BIRC211955515861135 19690564 Reconstituted Complex; Two-hybrid
JUPBIRC210682616189514 Two-hybrid
JUPBIRC210993116189514 Two-hybrid
MAGEA11BIRC210682616189514 Two-hybrid
MAGEA11BIRC211028416189514 Two-hybrid
XIAPBIRC210682816263936 Affinity Capture-Western
XIAPBIRC210682616263936 Affinity Capture-Western
FBXO7BIRC210682616510124 Affinity Capture-Western
FBXO7BIRC211732616510124 Affinity Capture-Western
XAF1BIRC210682617613533 Affinity Capture-Western
XAF1BIRC212012117613533 Affinity Capture-Western
HSP90B1BIRC210682618239673 Affinity Capture-Western; FRET
HSP90B1BIRC211303618239673 Affinity Capture-Western; FRET
RIPK1BIRC210682618570872 19854138 Affinity Capture-Western; Biochemical Activity
RIPK1BIRC211427418570872 19854138 Affinity Capture-Western; Biochemical Activity
ADRM1BIRC210682618939944 Affinity Capture-Western
ADRM1BIRC211623518939944 Affinity Capture-Western
RAF1BIRC210682619011619 Reconstituted Complex
RAF1BIRC211183119011619 Reconstituted Complex
UBE2WBIRC212057219690564 Two-hybrid
UBE2WBIRC210682619690564 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1197009
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030825-6'