AutismKB 2.0

Annotation Details for BIRC3


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Basic Information Top
Gene Symbol:BIRC3 ( AIP1,API2,CIAP2,HAIP1,HIAP1,MALT2,MIHC,RNF49,c-IAP2 )
Gene Full Name: baculoviral IAP repeat-containing 3
Band: 11q22.2
Quick LinksEntrez ID:330; OMIM: 601721; Uniprot ID:BIRC3_HUMAN; ENSEMBL ID: ENSG00000023445; HGNC ID: 591
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus15665297
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm15665297
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0043234IEA-protein complex-
GO:0045121IEA-membrane raft-
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity10797013
GO:0004842IDA-ubiquitin-protein transferase activity16395405
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11907583
GO:0016740EXP-transferase activity19008929
GO:0043027IBA-cysteine-type endopeptidase inhibitor activity involved in apoptotic process-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006915IEA-apoptotic process-
GO:0007166TAS-cell surface receptor signaling pathway8548810
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0007283IEA-spermatogenesis-
GO:0010803TAS-regulation of tumor necrosis factor-mediated signaling pathway-
GO:0016567IEA-protein ubiquitination-
GO:0016579TAS-protein deubiquitination-
GO:0031398IDA-positive regulation of protein ubiquitination21931591
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0034121TAS-regulation of toll-like receptor signaling pathway20888210
GO:0035666TAS-TRIF-dependent toll-like receptor signaling pathway-
GO:0038061TAS-NIK/NF-kappaB signaling20651737
GO:0039535TAS-regulation of RIG-I signaling pathway20888210
GO:0042981IMP-regulation of apoptotic process21737330
GO:0043066TAS-negative regulation of apoptotic process8552191
GO:0043123TAS-positive regulation of I-kappaB kinase/NF-kappaB signaling20651737
GO:0045088TAS-regulation of innate immune response21447281
GO:0050727TAS-regulation of inflammatory response21447281
GO:0051291IEA-protein heterooligomerization-
GO:0060544IMP-regulation of necroptotic process21737330
GO:0060544TAS-regulation of necroptotic process-
GO:0060546IBA-negative regulation of necroptotic process-
GO:0070424TAS-regulation of nucleotide-binding oligomerization domain containing signaling pathway20888210
GO:0090307IBANOTmitotic spindle assembly-
GO:1990001IBA-inhibition of cysteine-type endopeptidase activity involved in apoptotic process-
GO:2000116TAS-regulation of cysteine-type endopeptidase activity20651737
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRAF2BIRC31130388643514 9384571 10753917 11907583 16282325 20562859 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF2BIRC31068278643514 9384571 10753917 11907583 16282325 20562859 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF1BIRC31068279384571 11907583 Reconstituted Complex
TRAF1BIRC31130379384571 11907583 Reconstituted Complex
CASP3BIRC31068279384571 Reconstituted Complex
CASP3BIRC31072869384571 Reconstituted Complex
CASP7BIRC31068279384571 Reconstituted Complex
CASP7BIRC31072909384571 Reconstituted Complex
CASP9BIRC31068279545235 Affinity Capture-Western; Reconstituted Complex
CASP9BIRC31072929545235 Affinity Capture-Western; Reconstituted Complex
RIPK2BIRC31143009705938 Affinity Capture-Western
RIPK2BIRC31068279705938 Affinity Capture-Western
BCL10BIRC310682710753917 16775419 Affinity Capture-Western
BCL10BIRC311442910753917 16775419 Affinity Capture-Western
DIABLOBIRC310682710929712 12525502 14960576 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DIABLOBIRC312115710929712 12525502 14960576 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BIRC3BIRC310682711907583 18784070 Biochemical Activity; Co-crystal Structure
UBCBIRC311316412525502 18570872 Affinity Capture-Western
UBCBIRC310682712525502 18570872 Affinity Capture-Western
UBE2D1BIRC310682712525502 Affinity Capture-Western
UBE2D1BIRC311316912525502 Affinity Capture-Western
UBE2D3BIRC310682712525502 Affinity Capture-Western
UBE2D3BIRC311317112525502 Affinity Capture-Western
UBE2L3BIRC311318012525502 Affinity Capture-Western
UBE2L3BIRC310682712525502 Affinity Capture-Western
HTRA2BIRC311816512865429 Reconstituted Complex
HTRA2BIRC310682712865429 Reconstituted Complex
BIRC5BIRC310682715218035 Reconstituted Complex
BIRC5BIRC310682915218035 Reconstituted Complex
XAF1BIRC310682717613533 Affinity Capture-Western
XAF1BIRC312012117613533 Affinity Capture-Western
RIPK1BIRC310682718570872 Affinity Capture-Western; Biochemical Activity
RIPK1BIRC311427418570872 Affinity Capture-Western; Biochemical Activity
UBE2D2BIRC310682718784070 Co-crystal Structure; Reconstituted Complex
UBE2D2BIRC311317018784070 Co-crystal Structure; Reconstituted Complex
TNFRSF1ABIRC311298618939944 Affinity Capture-Western
TNFRSF1ABIRC310682718939944 Affinity Capture-Western
RAF1BIRC310682719011619 Reconstituted Complex
RAF1BIRC311183119011619 Reconstituted Complex
UBE2NBIRC310682719690564 Two-hybrid
UBE2NBIRC311318219690564 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
BIRC3rs3460 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1197007
  • Data Attributes: MGI curated and HomoloGene calculated
No data