Gene Symbol:	BIRC3 ( AIP1,API2,CIAP2,HAIP1,HIAP1,MALT2,MIHC,RNF49,c-IAP2 )
Gene Full Name:	baculoviral IAP repeat-containing 3
Band:	11q22.2
Quick Links	Entrez ID:330; OMIM: 601721; Uniprot ID:BIRC3_HUMAN; ENSEMBL ID: ENSG00000023445; HGNC ID: 591
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	15665297
GO:0005654	IDA	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	15665297
GO:0005829	IDA	-	cytosol	-
GO:0005829	TAS	-	cytosol	-
GO:0043234	IEA	-	protein complex	-
GO:0045121	IEA	-	membrane raft	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004842	EXP	-	ubiquitin-protein transferase activity	10797013
GO:0004842	IDA	-	ubiquitin-protein transferase activity	16395405
GO:0004842	TAS	-	ubiquitin-protein transferase activity	-
GO:0005515	IPI	-	protein binding	11907583
GO:0016740	EXP	-	transferase activity	19008929
GO:0043027	IBA	-	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	-
GO:0046872	IEA	-	metal ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0006915	IEA	-	apoptotic process	-
GO:0007166	TAS	-	cell surface receptor signaling pathway	8548810
GO:0007249	TAS	-	I-kappaB kinase/NF-kappaB signaling	-
GO:0007283	IEA	-	spermatogenesis	-
GO:0010803	TAS	-	regulation of tumor necrosis factor-mediated signaling pathway	-
GO:0016567	IEA	-	protein ubiquitination	-
GO:0016579	TAS	-	protein deubiquitination	-
GO:0031398	IDA	-	positive regulation of protein ubiquitination	21931591
GO:0033209	TAS	-	tumor necrosis factor-mediated signaling pathway	-
GO:0034121	TAS	-	regulation of toll-like receptor signaling pathway	20888210
GO:0035666	TAS	-	TRIF-dependent toll-like receptor signaling pathway	-
GO:0038061	TAS	-	NIK/NF-kappaB signaling	20651737
GO:0039535	TAS	-	regulation of RIG-I signaling pathway	20888210
GO:0042981	IMP	-	regulation of apoptotic process	21737330
GO:0043066	TAS	-	negative regulation of apoptotic process	8552191
GO:0043123	TAS	-	positive regulation of I-kappaB kinase/NF-kappaB signaling	20651737
GO:0045088	TAS	-	regulation of innate immune response	21447281
GO:0050727	TAS	-	regulation of inflammatory response	21447281
GO:0051291	IEA	-	protein heterooligomerization	-
GO:0060544	IMP	-	regulation of necroptotic process	21737330
GO:0060544	TAS	-	regulation of necroptotic process	-
GO:0060546	IBA	-	negative regulation of necroptotic process	-
GO:0070424	TAS	-	regulation of nucleotide-binding oligomerization domain containing signaling pathway	20888210
GO:0090307	IBA	NOT	mitotic spindle assembly	-
GO:1990001	IBA	-	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	-
GO:2000116	TAS	-	regulation of cysteine-type endopeptidase activity	20651737

Gene Symbol	Interactant	Interaction ID	References	Description
TRAF2	BIRC3	113038	8643514 9384571 10753917 11907583 16282325 20562859	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF2	BIRC3	106827	8643514 9384571 10753917 11907583 16282325 20562859	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF1	BIRC3	106827	9384571 11907583	Reconstituted Complex
TRAF1	BIRC3	113037	9384571 11907583	Reconstituted Complex
CASP3	BIRC3	106827	9384571	Reconstituted Complex
CASP3	BIRC3	107286	9384571	Reconstituted Complex
CASP7	BIRC3	106827	9384571	Reconstituted Complex
CASP7	BIRC3	107290	9384571	Reconstituted Complex
CASP9	BIRC3	106827	9545235	Affinity Capture-Western; Reconstituted Complex
CASP9	BIRC3	107292	9545235	Affinity Capture-Western; Reconstituted Complex
RIPK2	BIRC3	114300	9705938	Affinity Capture-Western
RIPK2	BIRC3	106827	9705938	Affinity Capture-Western
BCL10	BIRC3	106827	10753917 16775419	Affinity Capture-Western
BCL10	BIRC3	114429	10753917 16775419	Affinity Capture-Western
DIABLO	BIRC3	106827	10929712 12525502 14960576	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DIABLO	BIRC3	121157	10929712 12525502 14960576	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BIRC3	BIRC3	106827	11907583 18784070	Biochemical Activity; Co-crystal Structure
UBC	BIRC3	113164	12525502 18570872	Affinity Capture-Western
UBC	BIRC3	106827	12525502 18570872	Affinity Capture-Western
UBE2D1	BIRC3	106827	12525502	Affinity Capture-Western
UBE2D1	BIRC3	113169	12525502	Affinity Capture-Western
UBE2D3	BIRC3	106827	12525502	Affinity Capture-Western
UBE2D3	BIRC3	113171	12525502	Affinity Capture-Western
UBE2L3	BIRC3	113180	12525502	Affinity Capture-Western
UBE2L3	BIRC3	106827	12525502	Affinity Capture-Western
HTRA2	BIRC3	118165	12865429	Reconstituted Complex
HTRA2	BIRC3	106827	12865429	Reconstituted Complex
BIRC5	BIRC3	106827	15218035	Reconstituted Complex
BIRC5	BIRC3	106829	15218035	Reconstituted Complex
XAF1	BIRC3	106827	17613533	Affinity Capture-Western
XAF1	BIRC3	120121	17613533	Affinity Capture-Western
RIPK1	BIRC3	106827	18570872	Affinity Capture-Western; Biochemical Activity
RIPK1	BIRC3	114274	18570872	Affinity Capture-Western; Biochemical Activity
UBE2D2	BIRC3	106827	18784070	Co-crystal Structure; Reconstituted Complex
UBE2D2	BIRC3	113170	18784070	Co-crystal Structure; Reconstituted Complex
TNFRSF1A	BIRC3	112986	18939944	Affinity Capture-Western
TNFRSF1A	BIRC3	106827	18939944	Affinity Capture-Western
RAF1	BIRC3	106827	19011619	Reconstituted Complex
RAF1	BIRC3	111831	19011619	Reconstituted Complex
UBE2N	BIRC3	106827	19690564	Two-hybrid
UBE2N	BIRC3	113182	19690564	Two-hybrid

AutismKB 2.0

Annotation Details for BIRC3