AutismKB 2.0

Annotation Details for HSPA1A


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Basic Information Top
Gene Symbol:HSPA1A ( FLJ54303,FLJ54370,FLJ54392,FLJ54408,FLJ75127,HSP70-1,HSP70-1A,HSP70I,HSP72,HSPA1,HSPA1B )
Gene Full Name: heat shock 70kDa protein 1A
Band: 6p21.33
Quick LinksEntrez ID:3303; OMIM: 140550; Uniprot ID:HSP71_HUMAN; ENSEMBL ID: ENSG00000204389; HGNC ID: 5232
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IDAcolocalizes_withubiquitin ligase complex12150907
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus10205060
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm9553041
GO:0005737TAS-cytoplasm16130169
GO:0005739TAS-mitochondrion16130169
GO:0005783TAS-endoplasmic reticulum16130169
GO:0005813IDA-centrosome27137183
GO:0005814IDA-centriole24061851
GO:0005829IDA-cytosol21231916
GO:0005829TAS-cytosol-
GO:0005925IDA-focal adhesion21423176
GO:0016234IDA-inclusion body15603737
GO:0016235IDA-aggresome15885686
GO:0016607IDA-nuclear speck9553041
GO:0030529IDA-intracellular ribonucleoprotein complex17289661
GO:0031982IDA-vesicle19190083
GO:0048471IDA-perinuclear region of cytoplasm10205060
GO:0070062IDA-extracellular exosome19199708
GO:0072562IDA-blood microparticle22516433
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0001106IDA-RNA polymerase II transcription corepressor activity9499401
GO:0001618IEA-virus receptor activity-
GO:0001664IDA-G-protein coupled receptor binding12150907
GO:0003723IDA-RNA binding22658674
GO:0005102IPI-receptor binding24790089
GO:0005515IPI-protein binding9222587
GO:0005524IDA-ATP binding23921388
GO:0016887IDA-ATPase activity23921388
GO:0019899IPI-enzyme binding23921388
GO:0031072IPI-heat shock protein binding17182002
GO:0031249IPI-denatured protein binding21909508
GO:0031625IPI-ubiquitin protein ligase binding12150907
GO:0042623IDA-ATPase activity, coupled21231916
GO:0042623TAS-ATPase activity, coupled-
GO:0042826IPI-histone deacetylase binding16809764
GO:0044183IDA-protein binding involved in protein folding15603737
GO:0045296IDA-cadherin binding25468996
GO:0047485IPI-protein N-terminus binding9553041
GO:0051082IDA-unfolded protein binding21231916
GO:0051082NAS-unfolded protein binding12150907
GO:0051082TAS-unfolded protein binding16130169
GO:0055131IPI-C3HC4-type RING finger domain binding25281747
GO:0097718IPI-disordered domain specific binding11785981
GO ID Evidence Qualifier GO_term References
GO:0006402IDA-mRNA catabolic process10205060
GO:0006986IDA-response to unfolded protein10859165
GO:0008285IMP-negative regulation of cell proliferation9553041
GO:0010628IMP-positive regulation of gene expression25281747
GO:0010941IMPNOTregulation of cell death21231916
GO:0030308IMP-negative regulation of cell growth9553041
GO:0030512IMP-negative regulation of transforming growth factor beta receptor signaling pathway24613385
GO:0031396IDA-regulation of protein ubiquitination16809764
GO:0031397IDA-negative regulation of protein ubiquitination12150907
GO:0032436IDA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process24613385
GO:0032757IMP-positive regulation of interleukin-8 production24790089
GO:0034599TAS-cellular response to oxidative stress24252804
GO:0034605IDA-cellular response to heat24061851
GO:0042026IDA-protein refolding15603737
GO:0042026IMP-protein refolding27708256
GO:0043066TAS-negative regulation of apoptotic process16130169
GO:0043312TAS-neutrophil degranulation-
GO:0043488TAS-regulation of mRNA stability-
GO:0046034IDA-ATP metabolic process23921388
GO:0046718IEA-viral entry into host cell-
GO:0050821IDA-protein stabilization21909508
GO:0050821IMP-protein stabilization24790089
GO:0050821TAS-protein stabilization24252804
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity24790089
GO:0051131IDA-chaperone-mediated protein complex assembly10811660
GO:0060548IMP-negative regulation of cell death21231916
GO:0070370IMP-cellular heat acclimation21231916
GO:0070434IMP-positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway24790089
GO:0090063IMP-positive regulation of microtubule nucleation27137183
GO:0090084IDA-negative regulation of inclusion body assembly15603737
GO:0097201IDA-negative regulation of transcription from RNA polymerase II promoter in response to stress9499401
GO:1900034TAS-regulation of cellular response to heat-
GO:1901029IDA-negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway20625543
GO:1901673IMP-regulation of mitotic spindle assembly27137183
GO:1902236IDA-negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway12150907
GO:1902380IDA-positive regulation of endoribonuclease activity20625543
GO:1903265IMP-positive regulation of tumor necrosis factor-mediated signaling pathway24790089
GO:1904722IDA-positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response20625543
GO:2001240IMP-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand17167422
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HSPA1AAR1095351540595 Affinity Capture-Western
HSPA1AAR1068621540595 Affinity Capture-Western
HSPA1ARHOA10953512490434 Affinity Capture-Western
HSPA1ARHOA10688012490434 Affinity Capture-Western
HSPA1ABAG110953514517289 Reconstituted Complex
HSPA1ABAG110704914517289 Reconstituted Complex
HSPA1ABCL210953510354271 Affinity Capture-Western
HSPA1ABCL210706810354271 Affinity Capture-Western
HSPA1ACDK910953510617616 Affinity Capture-Western
HSPA1ACDK910745910617616 Affinity Capture-Western
HSPA1AEGFR10953520029029 PCA
HSPA1AEGFR10827620029029 PCA
HSPA1AFANCC10953512397061 14499622 Affinity Capture-Western; Two-hybrid
HSPA1AFANCC10847312397061 14499622 Affinity Capture-Western; Two-hybrid
HSPA1AGPR3710953512150907 Affinity Capture-Western; Reconstituted Complex
HSPA1AGPR3710911912150907 Affinity Capture-Western; Reconstituted Complex
HSPA1ANR3C110953512093808 Reconstituted Complex
HSPA1ANR3C110916512093808 Reconstituted Complex
HSPA1AHSF11095359499401 9699716 Affinity Capture-Western; Reconstituted Complex
HSPA1AHSF11095309499401 9699716 Affinity Capture-Western; Reconstituted Complex
ST13HSPA1A1095358887650 Reconstituted Complex
ST13HSPA1A1126448887650 Reconstituted Complex
STUB1HSPA1A10953510330192 12150907 Affinity Capture-Western; Reconstituted Complex
STUB1HSPA1A11556310330192 12150907 Affinity Capture-Western; Reconstituted Complex
BAG3HSPA1A10953510980614 11527400 Affinity Capture-Western
BAG3HSPA1A11490710980614 11527400 Affinity Capture-Western
BAT3HSPA1A10953511230127 Affinity Capture-Western
BAT3HSPA1A11364711230127 Affinity Capture-Western
SOX9HSPA1A11254511356186 Affinity Capture-Western
SOX9HSPA1A10953511356186 Affinity Capture-Western
AIFM1HSPA1A10953511533664 12930708 Affinity Capture-Western
AIFM1HSPA1A11457911533664 12930708 Affinity Capture-Western
MSR1HSPA1A10953511785981 Affinity Capture-Western; Reconstituted Complex
MSR1HSPA1A11058711785981 Affinity Capture-Western; Reconstituted Complex
IKBKGHSPA1A10953511877453 Reconstituted Complex
IKBKGHSPA1A11408911877453 Reconstituted Complex
SLC5A1HSPA1A10953512082088 Affinity Capture-Western
SLC5A1HSPA1A11241412082088 Affinity Capture-Western
HSP90AA1HSPA1A10953512093808 Reconstituted Complex
HSP90AA1HSPA1A10955212093808 Reconstituted Complex
PARK2HSPA1A10953512150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PARK2HSPA1A11110512150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
MAP3K5HSPA1A10953512391142 Affinity Capture-Western; Reconstituted Complex
MAP3K5HSPA1A11038112391142 Affinity Capture-Western; Reconstituted Complex
CUL4AHSPA1A11402912481031 Affinity Capture-MS
CUL4AHSPA1A10953512481031 Affinity Capture-MS
RBX1HSPA1A10953512481031 Affinity Capture-MS
RBX1HSPA1A11530112481031 Affinity Capture-MS
KDM1AHSPA1A10953516140033 Affinity Capture-MS
KDM1AHSPA1A11666716140033 Affinity Capture-MS
SRRM2HSPA1A11707116159877 Affinity Capture-MS
SRRM2HSPA1A10953516159877 Affinity Capture-MS
MYSM1HSPA1A12536317707232 Affinity Capture-MS
MYSM1HSPA1A10953517707232 Affinity Capture-MS
PACSIN2HSPA1A11641319041431 Affinity Capture-MS
PACSIN2HSPA1A10953519041431 Affinity Capture-MS
FNBP1HSPA1A11668619041431 Affinity Capture-MS
FNBP1HSPA1A10953519041431 Affinity Capture-MS
PACSIN3HSPA1A11889619041431 Affinity Capture-MS
PACSIN3HSPA1A10953519041431 Affinity Capture-MS
PACSIN1HSPA1A10953519041431 Affinity Capture-MS
PACSIN1HSPA1A11901819041431 Affinity Capture-MS
FCHSD1HSPA1A12461919041431 Affinity Capture-MS
FCHSD1HSPA1A10953519041431 Affinity Capture-MS
PSTPIP1HSPA1A10953519041431 Affinity Capture-MS
PSTPIP1HSPA1A11451319041431 Affinity Capture-MS
SUMO2HSPA1A10953519394292 Affinity Capture-MS
SUMO2HSPA1A11249719394292 Affinity Capture-MS
SNCBHSPA1A10953519875982 FRET
SNCBHSPA1A11250419875982 FRET
SNCAHSPA1A10953519875982 FRET; Reconstituted Complex
SNCAHSPA1A11250619875982 FRET; Reconstituted Complex
RAPGEF2HSPA1A10953520936779 Two-hybrid
RAPGEF2HSPA1A11504520936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
HSPA1Ars1008438 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
HSPA1AHSPA1A_-110A/C, rs1043618 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
HSPA1Ars1043618, rs562047 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96244
  • Data Attributes: MGI curated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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