Gene Symbol:	HSPA1A ( FLJ54303,FLJ54370,FLJ54392,FLJ54408,FLJ75127,HSP70-1,HSP70-1A,HSP70I,HSP72,HSPA1,HSPA1B )
Gene Full Name:	heat shock 70kDa protein 1A
Band:	6p21.33
Quick Links	Entrez ID:3303; OMIM: 140550; Uniprot ID:HSP71_HUMAN; ENSEMBL ID: ENSG00000204389; HGNC ID: 5232
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000151	IDA	colocalizes_with	ubiquitin ligase complex	12150907
GO:0005576	TAS	-	extracellular region	-
GO:0005634	IDA	-	nucleus	10205060
GO:0005654	TAS	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	9553041
GO:0005737	TAS	-	cytoplasm	16130169
GO:0005739	TAS	-	mitochondrion	16130169
GO:0005783	TAS	-	endoplasmic reticulum	16130169
GO:0005813	IDA	-	centrosome	27137183
GO:0005814	IDA	-	centriole	24061851
GO:0005829	IDA	-	cytosol	21231916
GO:0005829	TAS	-	cytosol	-
GO:0005925	IDA	-	focal adhesion	21423176
GO:0016234	IDA	-	inclusion body	15603737
GO:0016235	IDA	-	aggresome	15885686
GO:0016607	IDA	-	nuclear speck	9553041
GO:0030529	IDA	-	intracellular ribonucleoprotein complex	17289661
GO:0031982	IDA	-	vesicle	19190083
GO:0048471	IDA	-	perinuclear region of cytoplasm	10205060
GO:0070062	IDA	-	extracellular exosome	19199708
GO:0072562	IDA	-	blood microparticle	22516433
GO:1904813	TAS	-	ficolin-1-rich granule lumen	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001106	IDA	-	RNA polymerase II transcription corepressor activity	9499401
GO:0001618	IEA	-	virus receptor activity	-
GO:0001664	IDA	-	G-protein coupled receptor binding	12150907
GO:0003723	IDA	-	RNA binding	22658674
GO:0005102	IPI	-	receptor binding	24790089
GO:0005515	IPI	-	protein binding	9222587
GO:0005524	IDA	-	ATP binding	23921388
GO:0016887	IDA	-	ATPase activity	23921388
GO:0019899	IPI	-	enzyme binding	23921388
GO:0031072	IPI	-	heat shock protein binding	17182002
GO:0031249	IPI	-	denatured protein binding	21909508
GO:0031625	IPI	-	ubiquitin protein ligase binding	12150907
GO:0042623	IDA	-	ATPase activity, coupled	21231916
GO:0042623	TAS	-	ATPase activity, coupled	-
GO:0042826	IPI	-	histone deacetylase binding	16809764
GO:0044183	IDA	-	protein binding involved in protein folding	15603737
GO:0045296	IDA	-	cadherin binding	25468996
GO:0047485	IPI	-	protein N-terminus binding	9553041
GO:0051082	IDA	-	unfolded protein binding	21231916
GO:0051082	NAS	-	unfolded protein binding	12150907
GO:0051082	TAS	-	unfolded protein binding	16130169
GO:0055131	IPI	-	C3HC4-type RING finger domain binding	25281747
GO:0097718	IPI	-	disordered domain specific binding	11785981

GO ID	Evidence	Qualifier	GO_term	References
GO:0006402	IDA	-	mRNA catabolic process	10205060
GO:0006986	IDA	-	response to unfolded protein	10859165
GO:0008285	IMP	-	negative regulation of cell proliferation	9553041
GO:0010628	IMP	-	positive regulation of gene expression	25281747
GO:0010941	IMP	NOT	regulation of cell death	21231916
GO:0030308	IMP	-	negative regulation of cell growth	9553041
GO:0030512	IMP	-	negative regulation of transforming growth factor beta receptor signaling pathway	24613385
GO:0031396	IDA	-	regulation of protein ubiquitination	16809764
GO:0031397	IDA	-	negative regulation of protein ubiquitination	12150907
GO:0032436	IDA	-	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	24613385
GO:0032757	IMP	-	positive regulation of interleukin-8 production	24790089
GO:0034599	TAS	-	cellular response to oxidative stress	24252804
GO:0034605	IDA	-	cellular response to heat	24061851
GO:0042026	IDA	-	protein refolding	15603737
GO:0042026	IMP	-	protein refolding	27708256
GO:0043066	TAS	-	negative regulation of apoptotic process	16130169
GO:0043312	TAS	-	neutrophil degranulation	-
GO:0043488	TAS	-	regulation of mRNA stability	-
GO:0046034	IDA	-	ATP metabolic process	23921388
GO:0046718	IEA	-	viral entry into host cell	-
GO:0050821	IDA	-	protein stabilization	21909508
GO:0050821	IMP	-	protein stabilization	24790089
GO:0050821	TAS	-	protein stabilization	24252804
GO:0051092	IMP	-	positive regulation of NF-kappaB transcription factor activity	24790089
GO:0051131	IDA	-	chaperone-mediated protein complex assembly	10811660
GO:0060548	IMP	-	negative regulation of cell death	21231916
GO:0070370	IMP	-	cellular heat acclimation	21231916
GO:0070434	IMP	-	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	24790089
GO:0090063	IMP	-	positive regulation of microtubule nucleation	27137183
GO:0090084	IDA	-	negative regulation of inclusion body assembly	15603737
GO:0097201	IDA	-	negative regulation of transcription from RNA polymerase II promoter in response to stress	9499401
GO:1900034	TAS	-	regulation of cellular response to heat	-
GO:1901029	IDA	-	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	20625543
GO:1901673	IMP	-	regulation of mitotic spindle assembly	27137183
GO:1902236	IDA	-	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	12150907
GO:1902380	IDA	-	positive regulation of endoribonuclease activity	20625543
GO:1903265	IMP	-	positive regulation of tumor necrosis factor-mediated signaling pathway	24790089
GO:1904722	IDA	-	positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response	20625543
GO:2001240	IMP	-	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	17167422

Gene Symbol	Interactant	Interaction ID	References	Description
HSPA1A	AR	109535	1540595	Affinity Capture-Western
HSPA1A	AR	106862	1540595	Affinity Capture-Western
HSPA1A	RHOA	109535	12490434	Affinity Capture-Western
HSPA1A	RHOA	106880	12490434	Affinity Capture-Western
HSPA1A	BAG1	109535	14517289	Reconstituted Complex
HSPA1A	BAG1	107049	14517289	Reconstituted Complex
HSPA1A	BCL2	109535	10354271	Affinity Capture-Western
HSPA1A	BCL2	107068	10354271	Affinity Capture-Western
HSPA1A	CDK9	109535	10617616	Affinity Capture-Western
HSPA1A	CDK9	107459	10617616	Affinity Capture-Western
HSPA1A	EGFR	109535	20029029	PCA
HSPA1A	EGFR	108276	20029029	PCA
HSPA1A	FANCC	109535	12397061 14499622	Affinity Capture-Western; Two-hybrid
HSPA1A	FANCC	108473	12397061 14499622	Affinity Capture-Western; Two-hybrid
HSPA1A	GPR37	109535	12150907	Affinity Capture-Western; Reconstituted Complex
HSPA1A	GPR37	109119	12150907	Affinity Capture-Western; Reconstituted Complex
HSPA1A	NR3C1	109535	12093808	Reconstituted Complex
HSPA1A	NR3C1	109165	12093808	Reconstituted Complex
HSPA1A	HSF1	109535	9499401 9699716	Affinity Capture-Western; Reconstituted Complex
HSPA1A	HSF1	109530	9499401 9699716	Affinity Capture-Western; Reconstituted Complex
ST13	HSPA1A	109535	8887650	Reconstituted Complex
ST13	HSPA1A	112644	8887650	Reconstituted Complex
STUB1	HSPA1A	109535	10330192 12150907	Affinity Capture-Western; Reconstituted Complex
STUB1	HSPA1A	115563	10330192 12150907	Affinity Capture-Western; Reconstituted Complex
BAG3	HSPA1A	109535	10980614 11527400	Affinity Capture-Western
BAG3	HSPA1A	114907	10980614 11527400	Affinity Capture-Western
BAT3	HSPA1A	109535	11230127	Affinity Capture-Western
BAT3	HSPA1A	113647	11230127	Affinity Capture-Western
SOX9	HSPA1A	112545	11356186	Affinity Capture-Western
SOX9	HSPA1A	109535	11356186	Affinity Capture-Western
AIFM1	HSPA1A	109535	11533664 12930708	Affinity Capture-Western
AIFM1	HSPA1A	114579	11533664 12930708	Affinity Capture-Western
MSR1	HSPA1A	109535	11785981	Affinity Capture-Western; Reconstituted Complex
MSR1	HSPA1A	110587	11785981	Affinity Capture-Western; Reconstituted Complex
IKBKG	HSPA1A	109535	11877453	Reconstituted Complex
IKBKG	HSPA1A	114089	11877453	Reconstituted Complex
SLC5A1	HSPA1A	109535	12082088	Affinity Capture-Western
SLC5A1	HSPA1A	112414	12082088	Affinity Capture-Western
HSP90AA1	HSPA1A	109535	12093808	Reconstituted Complex
HSP90AA1	HSPA1A	109552	12093808	Reconstituted Complex
PARK2	HSPA1A	109535	12150907	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PARK2	HSPA1A	111105	12150907	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
MAP3K5	HSPA1A	109535	12391142	Affinity Capture-Western; Reconstituted Complex
MAP3K5	HSPA1A	110381	12391142	Affinity Capture-Western; Reconstituted Complex
CUL4A	HSPA1A	114029	12481031	Affinity Capture-MS
CUL4A	HSPA1A	109535	12481031	Affinity Capture-MS
RBX1	HSPA1A	109535	12481031	Affinity Capture-MS
RBX1	HSPA1A	115301	12481031	Affinity Capture-MS
KDM1A	HSPA1A	109535	16140033	Affinity Capture-MS
KDM1A	HSPA1A	116667	16140033	Affinity Capture-MS
SRRM2	HSPA1A	117071	16159877	Affinity Capture-MS
SRRM2	HSPA1A	109535	16159877	Affinity Capture-MS
MYSM1	HSPA1A	125363	17707232	Affinity Capture-MS
MYSM1	HSPA1A	109535	17707232	Affinity Capture-MS
PACSIN2	HSPA1A	116413	19041431	Affinity Capture-MS
PACSIN2	HSPA1A	109535	19041431	Affinity Capture-MS
FNBP1	HSPA1A	116686	19041431	Affinity Capture-MS
FNBP1	HSPA1A	109535	19041431	Affinity Capture-MS
PACSIN3	HSPA1A	118896	19041431	Affinity Capture-MS
PACSIN3	HSPA1A	109535	19041431	Affinity Capture-MS
PACSIN1	HSPA1A	109535	19041431	Affinity Capture-MS
PACSIN1	HSPA1A	119018	19041431	Affinity Capture-MS
FCHSD1	HSPA1A	124619	19041431	Affinity Capture-MS
FCHSD1	HSPA1A	109535	19041431	Affinity Capture-MS
PSTPIP1	HSPA1A	109535	19041431	Affinity Capture-MS
PSTPIP1	HSPA1A	114513	19041431	Affinity Capture-MS
SUMO2	HSPA1A	109535	19394292	Affinity Capture-MS
SUMO2	HSPA1A	112497	19394292	Affinity Capture-MS
SNCB	HSPA1A	109535	19875982	FRET
SNCB	HSPA1A	112504	19875982	FRET
SNCA	HSPA1A	109535	19875982	FRET; Reconstituted Complex
SNCA	HSPA1A	112506	19875982	FRET; Reconstituted Complex
RAPGEF2	HSPA1A	109535	20936779	Two-hybrid
RAPGEF2	HSPA1A	115045	20936779	Two-hybrid

AutismKB 2.0

Annotation Details for HSPA1A

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics