AutismKB 2.0

Annotation Details for HSPA1B


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Basic Information Top
Gene Symbol:HSPA1B ( FLJ54328,HSP70-1B,HSP70-2,HSPA1A )
Gene Full Name: heat shock 70kDa protein 1B
Band: 6p21.33
Quick LinksEntrez ID:3304; OMIM: 603012; Uniprot ID:HSP71_HUMAN; ENSEMBL ID: ENSG00000204388; HGNC ID: 5233
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IDAcolocalizes_withubiquitin ligase complex12150907
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus10205060
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm9553041
GO:0005737TAS-cytoplasm16130169
GO:0005739TAS-mitochondrion16130169
GO:0005783TAS-endoplasmic reticulum16130169
GO:0005813IDA-centrosome27137183
GO:0005814IDA-centriole24061851
GO:0005829IDA-cytosol21231916
GO:0005829TAS-cytosol-
GO:0005925IDA-focal adhesion21423176
GO:0016234IDA-inclusion body15603737
GO:0016235IDA-aggresome15885686
GO:0016607IDA-nuclear speck9553041
GO:0030529IDA-intracellular ribonucleoprotein complex17289661
GO:0031982IDA-vesicle19190083
GO:0048471IDA-perinuclear region of cytoplasm10205060
GO:0070062IDA-extracellular exosome19199708
GO:0072562IDA-blood microparticle22516433
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0001664IDA-G-protein coupled receptor binding12150907
GO:0003723IDA-RNA binding22658674
GO:0005102IPI-receptor binding24790089
GO:0005515IPI-protein binding15603737
GO:0005524IDA-ATP binding23921388
GO:0016887IDA-ATPase activity23921388
GO:0019899IPI-enzyme binding23921388
GO:0031072IPI-heat shock protein binding17182002
GO:0031625IPI-ubiquitin protein ligase binding12150907
GO:0042623IDA-ATPase activity, coupled21231916
GO:0042623TAS-ATPase activity, coupled-
GO:0042826IPI-histone deacetylase binding16809764
GO:0044183IDA-protein binding involved in protein folding15603737
GO:0047485IPI-protein N-terminus binding9553041
GO:0051082IDA-unfolded protein binding21231916
GO:0051082NAS-unfolded protein binding12150907
GO:0051082TAS-unfolded protein binding16130169
GO:0055131IPI-C3HC4-type RING finger domain binding25281747
GO ID Evidence Qualifier GO_term References
GO:0006402IDA-mRNA catabolic process10205060
GO:0008285IMP-negative regulation of cell proliferation9553041
GO:0010628IMP-positive regulation of gene expression25281747
GO:0010941IMPNOTregulation of cell death21231916
GO:0030308IMP-negative regulation of cell growth9553041
GO:0031396IDA-regulation of protein ubiquitination16809764
GO:0031397IDA-negative regulation of protein ubiquitination12150907
GO:0032757IMP-positive regulation of interleukin-8 production24790089
GO:0034599TAS-cellular response to oxidative stress24252804
GO:0034605IDA-cellular response to heat24061851
GO:0042026IDA-protein refolding15603737
GO:0042026IMP-protein refolding27708256
GO:0043066TAS-negative regulation of apoptotic process16130169
GO:0043312TAS-neutrophil degranulation-
GO:0046034IDA-ATP metabolic process23921388
GO:0046718IEA-viral entry into host cell-
GO:0050821IMP-protein stabilization24790089
GO:0050821TAS-protein stabilization24252804
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity24790089
GO:0060548IDA-negative regulation of cell death12150907
GO:0060548IMP-negative regulation of cell death21231916
GO:0070370IMP-cellular heat acclimation21231916
GO:0070434IMP-positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway24790089
GO:0090063IMP-positive regulation of microtubule nucleation27137183
GO:0090084IDA-negative regulation of inclusion body assembly15603737
GO:1900034TAS-regulation of cellular response to heat-
GO:1901673IMP-regulation of mitotic spindle assembly27137183
GO:1903265IMP-positive regulation of tumor necrosis factor-mediated signaling pathway24790089
GO:2001240IMP-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand17167422
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PGAM5HSPA1B12815416169070 Two-hybrid
PGAM5HSPA1B10953616169070 Two-hybrid
BANF1HSPA1B10953619759913 Affinity Capture-MS
BANF1HSPA1B11434219759913 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
HSPA1B3'UTR 5bp, cHSP70_AG Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
HSPA1BHSPA1B_+1267A/G, rs539689 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
HSPA1Brs539689 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:99517
  • Data Attributes: MGI curated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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