AutismKB 2.0

Annotation Details for HSPA1L


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Basic Information Top
Gene Symbol:HSPA1L ( HSP70-1L,HSP70-HOM,HSP70T,hum70t )
Gene Full Name: heat shock 70kDa protein 1-like
Band: 6p21.33
Quick LinksEntrez ID:3305; OMIM: 140559; Uniprot ID:HS71L_HUMAN; ENSEMBL ID: ENSG00000204390; HGNC ID: 5234
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0002199IEA-zona pellucida receptor complex-
GO:0005654TAS-nucleoplasm-
GO:0005759IEA-mitochondrial matrix-
GO:0005829IDA-cytosol21231916
GO:0008180IDAcolocalizes_withCOP9 signalosome18850735
GO:0044297IEA-cell body-
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding17184779
GO:0005524IEA-ATP binding-
GO:0031072IPI-heat shock protein binding17182002
GO:0031625IPI-ubiquitin protein ligase binding24270810
GO:0051082IDA-unfolded protein binding21231916
GO ID Evidence Qualifier GO_term References
GO:0006986TAS-response to unfolded protein9685725
GO:0007339IEA-binding of sperm to zona pellucida-
GO:0042026IDA-protein refolding21231916
GO:1900034TAS-regulation of cellular response to heat-
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24270810
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RUVBL2HSPA1L10953717643375 Affinity Capture-MS
RUVBL2HSPA1L11606717643375 Affinity Capture-MS
RUVBL1HSPA1L11416617643375 Affinity Capture-MS
RUVBL1HSPA1L10953717643375 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
HSPA1Lrs2227956 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
HSPA1LHSPA1L_+2437T/C Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
HSPA1Lrs1061581, rs2075799, rs2227956 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96231
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018