Gene Symbol:	HSPB1 ( CMT2F,DKFZp586P1322,HMN2B,HS.76067,HSP27,HSP28,Hsp25,SRP27 )
Gene Full Name:	heat shock 27kDa protein 1
Band:	7q11.23
Quick Links	Entrez ID:3315; OMIM: 602195; Uniprot ID:HSPB1_HUMAN; ENSEMBL ID: ENSG00000106211; HGNC ID: 5246
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000502	ISS	-	proteasome complex	-
GO:0005615	IDA	-	extracellular space	22664934
GO:0005634	IDA	-	nucleus	19464326
GO:0005737	IDA	-	cytoplasm	19464326
GO:0005737	TAS	-	cytoplasm	16130169
GO:0005819	IEA	-	spindle	-
GO:0005829	TAS	-	cytosol	-
GO:0005856	TAS	-	cytoskeleton	16130169
GO:0005886	IEA	-	plasma membrane	-
GO:0005925	IDA	-	focal adhesion	21423176
GO:0030018	IEA	-	Z disc	-
GO:0031012	IDA	-	extracellular matrix	23979707
GO:0070062	IDA	-	extracellular exosome	19056867
GO:1904115	IEA	-	axon cytoplasm	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003723	IDA	-	RNA binding	22658674
GO:0005080	ISS	-	protein kinase C binding	-
GO:0005515	IPI	-	protein binding	11003656
GO:0008426	ISS	-	protein kinase C inhibitor activity	-
GO:0019901	IPI	-	protein kinase binding	8774846
GO:0042802	IMP	-	identical protein binding	20178975
GO:0042802	IPI	-	identical protein binding	11003656
GO:0042803	IDA	-	protein homodimerization activity	28144995
GO:0043130	ISS	-	ubiquitin binding	-
GO:0044183	IMP	-	protein binding involved in protein folding	20178975

GO ID	Evidence	Qualifier	GO_term	References
GO:0001895	IEP	-	retina homeostasis	23580065
GO:0001932	IMP	-	regulation of protein phosphorylation	23728742
GO:0006446	TAS	-	regulation of translational initiation	10859165
GO:0006469	ISS	-	negative regulation of protein kinase activity	-
GO:0006928	TAS	-	movement of cell or subcellular component	16130169
GO:0006986	NAS	-	response to unfolded protein	1560006
GO:0009615	IEP	-	response to virus	16548883
GO:0010506	NAS	-	regulation of autophagy	25962073
GO:0032731	ISS	-	positive regulation of interleukin-1 beta production	-
GO:0035556	IMP	-	intracellular signal transduction	18440775
GO:0035924	IMP	-	cellular response to vascular endothelial growth factor stimulus	18440775
GO:0038033	IMP	-	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	18440775
GO:0042535	ISS	-	positive regulation of tumor necrosis factor biosynthetic process	-
GO:0043066	TAS	-	negative regulation of apoptotic process	16130169
GO:0043122	ISS	-	regulation of I-kappaB kinase/NF-kappaB signaling	-
GO:0043488	TAS	-	regulation of mRNA stability	-
GO:0043536	IMP	-	positive regulation of blood vessel endothelial cell migration	18440775
GO:0045766	IMP	-	positive regulation of angiogenesis	18440775
GO:0048010	TAS	-	vascular endothelial growth factor receptor signaling pathway	-
GO:0061077	IMP	-	chaperone-mediated protein folding	20178975
GO:0070527	IMP	-	platelet aggregation	23382103
GO:0071901	IEA	-	negative regulation of protein serine/threonine kinase activity	-
GO:0099641	IMP	-	anterograde axonal protein transport	23728742
GO:1902176	ISS	-	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	-
GO:2001028	IMP	-	positive regulation of endothelial cell chemotaxis	18440775

Gene Symbol	Interactant	Interaction ID	References	Description
HSPB1	AKT1	106710	11042204	Affinity Capture-Western
HSPB1	AKT1	109547	11042204	Affinity Capture-Western
HSPB1	CRYAA	107799	11700327	Affinity Capture-Western; Two-hybrid
HSPB1	CRYAA	109547	11700327	Affinity Capture-Western; Two-hybrid
HSPB1	CRYAB	107800	1560006 11700327	Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
HSPB1	CRYAB	109547	1560006 11700327	Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
HSPB1	CRYBB2	107805	11700327	Affinity Capture-Western; Two-hybrid
HSPB1	CRYBB2	109547	11700327	Affinity Capture-Western; Two-hybrid
HSPB1	DMWD	108102	19615732	Affinity Capture-MS
HSPB1	DMWD	109547	19615732	Affinity Capture-MS
HSPB1	HNRNPD	109547	18573886	Affinity Capture-MS; Affinity Capture-Western; FRET
HSPB1	HNRNPD	109425	18573886	Affinity Capture-MS; Affinity Capture-Western; FRET
MAPKAPK5	HSPB1	109547	9628874	Biochemical Activity
MAPKAPK5	HSPB1	114120	9628874	Biochemical Activity
MAPKAPK2	HSPB1	109547	11042204	Affinity Capture-Western
MAPKAPK2	HSPB1	114683	11042204	Affinity Capture-Western
TGFB1I1	HSPB1	109547	11546764	Affinity Capture-Western; Two-hybrid
TGFB1I1	HSPB1	112899	11546764	Affinity Capture-Western; Two-hybrid
CYCS	HSPB1	109547	11784858	Affinity Capture-Western
CYCS	HSPB1	119922	11784858	Affinity Capture-Western
HSPB8	HSPB1	109547	14594798 15122253	Affinity Capture-Western; Two-hybrid
HSPB8	HSPB1	117689	14594798 15122253	Affinity Capture-Western; Two-hybrid
PRKD1	HSPB1	109547	15728188	Biochemical Activity; Reconstituted Complex
PRKD1	HSPB1	111573	15728188	Biochemical Activity; Reconstituted Complex
SRRM2	HSPB1	109547	16159877	Affinity Capture-MS
SRRM2	HSPB1	117071	16159877	Affinity Capture-MS
MED31	HSPB1	109547	16169070	Two-hybrid
MED31	HSPB1	119211	16169070	Two-hybrid
PPA1	HSPB1	109547	16169070	Two-hybrid
PPA1	HSPB1	111460	16169070	Two-hybrid
C1orf103	HSPB1	109547	16169070	Two-hybrid
C1orf103	HSPB1	120905	16169070	Two-hybrid
TP53	HSPB1	109547	16169070	Two-hybrid
TP53	HSPB1	113010	16169070	Two-hybrid
C7orf64	HSPB1	109547	16169070	Two-hybrid
C7orf64	HSPB1	123855	16169070	Two-hybrid
IGSF21	HSPB1	109547	16169070	Two-hybrid
IGSF21	HSPB1	124396	16169070	Two-hybrid
ILK	HSPB1	109824	17353931	Affinity Capture-MS
ILK	HSPB1	109547	17353931	Affinity Capture-MS
MAGED1	HSPB1	109547	17353931	Affinity Capture-MS
MAGED1	HSPB1	114879	17353931	Affinity Capture-MS
USP1	HSPB1	109547	19615732	Affinity Capture-MS
USP1	HSPB1	113241	19615732	Affinity Capture-MS
USP38	HSPB1	109547	19615732	Affinity Capture-MS
USP38	HSPB1	124165	19615732	Affinity Capture-MS

AutismKB 2.0

Annotation Details for HSPB1