AutismKB 2.0

Annotation Details for HSPB1


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Basic Information Top
Gene Symbol:HSPB1 ( CMT2F,DKFZp586P1322,HMN2B,HS.76067,HSP27,HSP28,Hsp25,SRP27 )
Gene Full Name: heat shock 27kDa protein 1
Band: 7q11.23
Quick LinksEntrez ID:3315; OMIM: 602195; Uniprot ID:HSPB1_HUMAN; ENSEMBL ID: ENSG00000106211; HGNC ID: 5246
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000502ISS-proteasome complex-
GO:0005615IDA-extracellular space22664934
GO:0005634IDA-nucleus19464326
GO:0005737IDA-cytoplasm19464326
GO:0005737TAS-cytoplasm16130169
GO:0005819IEA-spindle-
GO:0005829TAS-cytosol-
GO:0005856TAS-cytoskeleton16130169
GO:0005886IEA-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0030018IEA-Z disc-
GO:0031012IDA-extracellular matrix23979707
GO:0070062IDA-extracellular exosome19056867
GO:1904115IEA-axon cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005080ISS-protein kinase C binding-
GO:0005515IPI-protein binding11003656
GO:0008426ISS-protein kinase C inhibitor activity-
GO:0019901IPI-protein kinase binding8774846
GO:0042802IMP-identical protein binding20178975
GO:0042802IPI-identical protein binding11003656
GO:0042803IDA-protein homodimerization activity28144995
GO:0043130ISS-ubiquitin binding-
GO:0044183IMP-protein binding involved in protein folding20178975
GO ID Evidence Qualifier GO_term References
GO:0001895IEP-retina homeostasis23580065
GO:0001932IMP-regulation of protein phosphorylation23728742
GO:0006446TAS-regulation of translational initiation10859165
GO:0006469ISS-negative regulation of protein kinase activity-
GO:0006928TAS-movement of cell or subcellular component16130169
GO:0006986NAS-response to unfolded protein1560006
GO:0009615IEP-response to virus16548883
GO:0010506NAS-regulation of autophagy25962073
GO:0032731ISS-positive regulation of interleukin-1 beta production-
GO:0035556IMP-intracellular signal transduction18440775
GO:0035924IMP-cellular response to vascular endothelial growth factor stimulus18440775
GO:0038033IMP-positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway18440775
GO:0042535ISS-positive regulation of tumor necrosis factor biosynthetic process-
GO:0043066TAS-negative regulation of apoptotic process16130169
GO:0043122ISS-regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043488TAS-regulation of mRNA stability-
GO:0043536IMP-positive regulation of blood vessel endothelial cell migration18440775
GO:0045766IMP-positive regulation of angiogenesis18440775
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0061077IMP-chaperone-mediated protein folding20178975
GO:0070527IMP-platelet aggregation23382103
GO:0071901IEA-negative regulation of protein serine/threonine kinase activity-
GO:0099641IMP-anterograde axonal protein transport23728742
GO:1902176ISS-negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-
GO:2001028IMP-positive regulation of endothelial cell chemotaxis18440775
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HSPB1AKT110671011042204 Affinity Capture-Western
HSPB1AKT110954711042204 Affinity Capture-Western
HSPB1CRYAA10779911700327 Affinity Capture-Western; Two-hybrid
HSPB1CRYAA10954711700327 Affinity Capture-Western; Two-hybrid
HSPB1CRYAB1078001560006 11700327 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
HSPB1CRYAB1095471560006 11700327 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
HSPB1CRYBB210780511700327 Affinity Capture-Western; Two-hybrid
HSPB1CRYBB210954711700327 Affinity Capture-Western; Two-hybrid
HSPB1DMWD10810219615732 Affinity Capture-MS
HSPB1DMWD10954719615732 Affinity Capture-MS
HSPB1HNRNPD10954718573886 Affinity Capture-MS; Affinity Capture-Western; FRET
HSPB1HNRNPD10942518573886 Affinity Capture-MS; Affinity Capture-Western; FRET
MAPKAPK5HSPB11095479628874 Biochemical Activity
MAPKAPK5HSPB11141209628874 Biochemical Activity
MAPKAPK2HSPB110954711042204 Affinity Capture-Western
MAPKAPK2HSPB111468311042204 Affinity Capture-Western
TGFB1I1HSPB110954711546764 Affinity Capture-Western; Two-hybrid
TGFB1I1HSPB111289911546764 Affinity Capture-Western; Two-hybrid
CYCSHSPB110954711784858 Affinity Capture-Western
CYCSHSPB111992211784858 Affinity Capture-Western
HSPB8HSPB110954714594798 15122253 Affinity Capture-Western; Two-hybrid
HSPB8HSPB111768914594798 15122253 Affinity Capture-Western; Two-hybrid
PRKD1HSPB110954715728188 Biochemical Activity; Reconstituted Complex
PRKD1HSPB111157315728188 Biochemical Activity; Reconstituted Complex
SRRM2HSPB110954716159877 Affinity Capture-MS
SRRM2HSPB111707116159877 Affinity Capture-MS
MED31HSPB110954716169070 Two-hybrid
MED31HSPB111921116169070 Two-hybrid
PPA1HSPB110954716169070 Two-hybrid
PPA1HSPB111146016169070 Two-hybrid
C1orf103HSPB110954716169070 Two-hybrid
C1orf103HSPB112090516169070 Two-hybrid
TP53HSPB110954716169070 Two-hybrid
TP53HSPB111301016169070 Two-hybrid
C7orf64HSPB110954716169070 Two-hybrid
C7orf64HSPB112385516169070 Two-hybrid
IGSF21HSPB110954716169070 Two-hybrid
IGSF21HSPB112439616169070 Two-hybrid
ILKHSPB110982417353931 Affinity Capture-MS
ILKHSPB110954717353931 Affinity Capture-MS
MAGED1HSPB110954717353931 Affinity Capture-MS
MAGED1HSPB111487917353931 Affinity Capture-MS
USP1HSPB110954719615732 Affinity Capture-MS
USP1HSPB111324119615732 Affinity Capture-MS
USP38HSPB110954719615732 Affinity Capture-MS
USP38HSPB112416519615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96240
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030326-4'