AutismKB 2.0

Annotation Details for HSP90AA1


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Basic Information Top
Gene Symbol:HSP90AA1 ( FLJ31884,HSP86,HSP89A,HSP90A,HSP90N,HSPC1,HSPCA,HSPCAL1,HSPCAL4,HSPN,Hsp89,Hsp90,LAP2 )
Gene Full Name: heat shock protein 90kDa alpha (cytosolic), class A member 1
Band: 14q32.31
Quick LinksEntrez ID:3320; OMIM: 140571; Uniprot ID:HS90A_HUMAN; ENSEMBL ID: ENSG00000080824; HGNC ID: 5253
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus21630459
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm10791971
GO:0005737ISS-cytoplasm-
GO:0005829NAS-cytosol12526792
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0016020IDA-membrane19946888
GO:0032587IEA-ruffle membrane-
GO:0034774TAS-secretory granule lumen-
GO:0042470IEA-melanosome-
GO:0043202TAS-lysosomal lumen25719862
GO:0043209IEA-myelin sheath-
GO:0070062IDA-extracellular exosome11487543
GO:0071682TAS-endocytic vesicle lumen-
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0000166TAS-nucleotide binding11470816
GO:0003723IDA-RNA binding22658674
GO:0004713EXP-protein tyrosine kinase activity17349580
GO:0005515IPI-protein binding9660753
GO:0005524IDA-ATP binding27353360
GO:0005524TAS-ATP binding11470816
GO:0016887IDA-ATPase activity15937123
GO:0023026IDA-MHC class II protein complex binding20458337
GO:0030235IDA-nitric-oxide synthase regulator activity15937123
GO:0030911IDA-TPR domain binding9660753
GO:0030911TAS-TPR domain binding12526792
GO:0042802IPI-identical protein binding8289821
GO:0042803TAS-protein homodimerization activity11470816
GO:0042826IPI-histone deacetylase binding16809764
GO:0051020IPI-GTPase binding24337748
GO:0051082IEA-unfolded protein binding-
GO:0070182IPI-DNA polymerase binding10197982
GO:0097718IPI-disordered domain specific binding15713458
GO:1990782IPI-protein tyrosine kinase binding20353823
GO ID Evidence Qualifier GO_term References
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0006839TAS-mitochondrial transport12526792
GO:0006898TAS-receptor-mediated endocytosis-
GO:0006986NAS-response to unfolded protein2527334
GO:0007004IDA-telomere maintenance via telomerase10197982
GO:0007165NAS-signal transduction11470816
GO:0009408ISS-response to heat-
GO:0009409ISS-response to cold-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0031396IDA-regulation of protein ubiquitination16809764
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0042026TAS-protein refolding9660753
GO:0043254NAS-regulation of protein complex assembly20176123
GO:0043312TAS-neutrophil degranulation-
GO:0043335NAS-protein unfolding20176123
GO:0045040IDA-protein import into mitochondrial outer membrane15644312
GO:0045429ISS-positive regulation of nitric oxide biosynthetic process-
GO:0046677ISS-response to antibiotic-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0050821IMP-protein stabilization27353360
GO:0050821TAS-protein stabilization-
GO:0050999TAS-regulation of nitric-oxide synthase activity-
GO:0051131IDA-chaperone-mediated protein complex assembly15644312
GO:0051973IDA-positive regulation of telomerase activity10197982
GO:0061684TAS-chaperone-mediated autophagy25719862
GO:0097711TAS-ciliary basal body docking-
GO:1900034TAS-regulation of cellular response to heat-
GO:1905323IDA-telomerase holoenzyme complex assembly10197982
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HSP90AA1ABL110955215937340 Affinity Capture-Western
HSP90AA1ABL110654315937340 Affinity Capture-Western
HSP90AA1AHR1066999083006 Affinity Capture-Western
HSP90AA1AHR1095529083006 Affinity Capture-Western
HSP90AA1AKT110955210995457 12176997 12586360 15843522 Affinity Capture-Western
HSP90AA1AKT110671010995457 12176997 12586360 15843522 Affinity Capture-Western
HSP90AA1APAF110955210934467 Affinity Capture-Western
HSP90AA1APAF110681410934467 Affinity Capture-Western
HSP90AA1AR1095521525041 1540595 17974989 Affinity Capture-Western; Reconstituted Complex
HSP90AA1AR1068621525041 1540595 17974989 Affinity Capture-Western; Reconstituted Complex
HSP90AA1ARNT10689811013261 Affinity Capture-Western
HSP90AA1ARNT10955211013261 Affinity Capture-Western
HSP90AA1ARNTL1095529079689 Reconstituted Complex
HSP90AA1ARNTL1068999079689 Reconstituted Complex
HSP90AA1CDK11B10955215344906 Affinity Capture-MS
HSP90AA1CDK11B10742115344906 Affinity Capture-MS
HSP90AA1CSNK2A11095527794926 Reconstituted Complex
HSP90AA1CSNK2A11078417794926 Reconstituted Complex
HSP90AA1CSNK2A21095527794926 Reconstituted Complex
HSP90AA1CSNK2A21078427794926 Reconstituted Complex
HSP90AA1DAPK110955217324930 Affinity Capture-Western
HSP90AA1DAPK110798217324930 Affinity Capture-Western
HSP90AA1EGFR10955212006493 Affinity Capture-Western
HSP90AA1EGFR10827612006493 Affinity Capture-Western
HSP90AA1EPRS10837210913161 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
HSP90AA1EPRS10955210913161 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
HSP90AA1ERBB210837611071886 12006493 18655187 20159553 Affinity Capture-Western
HSP90AA1ERBB210955211071886 12006493 18655187 20159553 Affinity Capture-Western
HSP90AA1ERN110839112446770 Affinity Capture-Western; Reconstituted Complex
HSP90AA1ERN110955212446770 Affinity Capture-Western; Reconstituted Complex
HSP90AA1ESR11084039222609 11911945 15538384 16037132 17699868 Affinity Capture-Western; Reconstituted Complex
HSP90AA1ESR11095529222609 11911945 15538384 16037132 17699868 Affinity Capture-Western; Reconstituted Complex
HSP90AA1FANCA10847214499622 Two-hybrid
HSP90AA1FANCA10955214499622 Two-hybrid
HSP90AA1FANCC10847314499622 Two-hybrid
HSP90AA1FANCC10955214499622 Two-hybrid
HSP90AA1FES1085339222609 Reconstituted Complex
HSP90AA1FES1095529222609 Reconstituted Complex
HSP90AA1FKBP410857821170051 Reconstituted Complex
HSP90AA1FKBP410955221170051 Reconstituted Complex
HSP90AA1FKBP51085799001212 21170051 Affinity Capture-Western; Reconstituted Complex
HSP90AA1FKBP51095529001212 21170051 Affinity Capture-Western; Reconstituted Complex
HSP90AA1FLT310861018394702 Affinity Capture-Western
HSP90AA1FLT310955218394702 Affinity Capture-Western
HSP90AA1GNA1210903011598136 Affinity Capture-Western; Two-hybrid
HSP90AA1GNA1210955211598136 Affinity Capture-Western; Two-hybrid
HSP90AA1NR3C11091658621522 8645634 8898375 9334248 10066374 10903152 12093808 15916966 16087666 Affinity Capture-Western; Co-localization; Reconstituted Complex
HSP90AA1NR3C11095528621522 8645634 8898375 9334248 10066374 10903152 12093808 15916966 16087666 Affinity Capture-Western; Co-localization; Reconstituted Complex
HSP90AA1GUCY1A210923217873020 Affinity Capture-Western
HSP90AA1GUCY1A210955217873020 Affinity Capture-Western
HSP90AA1GUCY1B310923812676772 Affinity Capture-Western; Reconstituted Complex
HSP90AA1GUCY1B310955212676772 Affinity Capture-Western; Reconstituted Complex
HSP90AA1HCFC110930412670868 Affinity Capture-MS
HSP90AA1HCFC110955212670868 Affinity Capture-MS
HSP90AA1HIF1A1093389079689 14726529 15147973 16507982 16951198 Affinity Capture-Western; Reconstituted Complex
HSP90AA1HIF1A1095529079689 14726529 15147973 16507982 16951198 Affinity Capture-Western; Reconstituted Complex
HSP90AA1HSF11095309222609 12621024 Affinity Capture-Western; Reconstituted Complex
HSP90AA1HSF11095529222609 12621024 Affinity Capture-Western; Reconstituted Complex
HSP90AA1HSPA1A10953512093808 Reconstituted Complex
HSP90AA1HSPA1A10955212093808 Reconstituted Complex
HSP90AA1HSPA410954016314389 Affinity Capture-Western
HSP90AA1HSPA410955216314389 Affinity Capture-Western
HSP90AA1HSPA81095449269769 Affinity Capture-Western
HSP90AA1HSPA81095529269769 Affinity Capture-Western
SRCHSP90AA11125921310678 Affinity Capture-Western
SRCHSP90AA11095521310678 Affinity Capture-Western
MYOD1HSP90AA11107371406681 Reconstituted Complex
MYOD1HSP90AA11095521406681 Reconstituted Complex
RAF1HSP90AA11118318408024 16504566 17409432 17699868 19011619 20159553 Affinity Capture-Western
RAF1HSP90AA11095528408024 16504566 17409432 17699868 19011619 20159553 Affinity Capture-Western
SIM1HSP90AA11095529020169 Reconstituted Complex
SIM1HSP90AA11123839020169 Reconstituted Complex
NPAS2HSP90AA11109239079689 Reconstituted Complex
NPAS2HSP90AA11095529079689 Reconstituted Complex
STIP1HSP90AA11161629452498 10786835 20159553 21170051 Affinity Capture-Western; Reconstituted Complex
STIP1HSP90AA11095529452498 10786835 20159553 21170051 Affinity Capture-Western; Reconstituted Complex
CDC37HSP90AA11095529685350 12176997 14718169 20159553 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
CDC37HSP90AA11163129685350 12176997 14718169 20159553 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
DAP3HSP90AA111358710903152 Affinity Capture-Western; Reconstituted Complex
DAP3HSP90AA110955210903152 Affinity Capture-Western; Reconstituted Complex
AIPHSP90AA111451111013261 21170051 Affinity Capture-Western; Reconstituted Complex
AIPHSP90AA110955211013261 21170051 Affinity Capture-Western; Reconstituted Complex
PIM1HSP90AA111131011237709 Affinity Capture-MS; Affinity Capture-Western
PIM1HSP90AA110955211237709 Affinity Capture-MS; Affinity Capture-Western
TP53HSP90AA110955211297531 11507088 12427754 Affinity Capture-Western
TP53HSP90AA111301011297531 11507088 12427754 Affinity Capture-Western
EIF2AK2HSP90AA111159611447118 Affinity Capture-Western
EIF2AK2HSP90AA110955211447118 Affinity Capture-Western
NOS3HSP90AA111090911744239 12124224 12676772 Affinity Capture-Western; Reconstituted Complex
NOS3HSP90AA110955211744239 12124224 12676772 Affinity Capture-Western; Reconstituted Complex
PTGES3HSP90AA111595211812147 15916966 20159553 Affinity Capture-Western; Reconstituted Complex
PTGES3HSP90AA110955211812147 15916966 20159553 Affinity Capture-Western; Reconstituted Complex
IRS4HSP90AA111404811912194 Affinity Capture-MS
IRS4HSP90AA110955211912194 Affinity Capture-MS
EIF2AK3HSP90AA110955212446770 Affinity Capture-Western
EIF2AK3HSP90AA111484012446770 Affinity Capture-Western
CUL4AHSP90AA111402912481031 Affinity Capture-MS
CUL4AHSP90AA110955212481031 Affinity Capture-MS
SGTAHSP90AA111234712482202 Far Western
SGTAHSP90AA110955212482202 Far Western
PPARAHSP90AA111146112482853 Affinity Capture-Western; Reconstituted Complex
PPARAHSP90AA110955212482853 Affinity Capture-Western; Reconstituted Complex
STK11HSP90AA111267012489981 14668798 Affinity Capture-Western; Reconstituted Complex
STK11HSP90AA110955212489981 14668798 Affinity Capture-Western; Reconstituted Complex
AHSA2HSP90AA112626112504007 Affinity Capture-Western; Reconstituted Complex
AHSA2HSP90AA110955212504007 Affinity Capture-Western; Reconstituted Complex
AHSA1HSP90AA111584612504007 20159553 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AHSA1HSP90AA110955212504007 20159553 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STAT3HSP90AA111265112559950 Affinity Capture-Western
STAT3HSP90AA110955212559950 Affinity Capture-Western
TERTHSP90AA111287412586360 15843522 Affinity Capture-Western
TERTHSP90AA110955212586360 15843522 Affinity Capture-Western
RALBP1HSP90AA110955212621024 Affinity Capture-Western
RALBP1HSP90AA111613112621024 Affinity Capture-Western
TUBA1AHSP90AA110955212621024 Affinity Capture-Western
TUBA1AHSP90AA111360312621024 Affinity Capture-Western
MYCHSP90AA111069412644583 Affinity Capture-Western
MYCHSP90AA110955212644583 Affinity Capture-Western
UBCHSP90AA111316412821935 16196087 Affinity Capture-Western
UBCHSP90AA110955212821935 16196087 Affinity Capture-Western
CHTF18HSP90AA110955212930902 Affinity Capture-MS
CHTF18HSP90AA112199112930902 Affinity Capture-MS
BAG4HSP90AA111490614559896 Affinity Capture-Western
BAG4HSP90AA110955214559896 Affinity Capture-Western
STARD13HSP90AA112474414697242 Two-hybrid
STARD13HSP90AA110955214697242 Two-hybrid
LSM1HSP90AA111810415231747 Two-hybrid
LSM1HSP90AA110955215231747 Two-hybrid
SMYD3HSP90AA112226815235609 Affinity Capture-Western
SMYD3HSP90AA110955215235609 Affinity Capture-Western
PPP5CHSP90AA111152815383005 Affinity Capture-MS
PPP5CHSP90AA110955215383005 Affinity Capture-MS
STUB1HSP90AA110955215538384 16307917 17324930 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1HSP90AA111556315538384 16307917 17324930 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TSSK6HSP90AA110955215870294 Affinity Capture-MS
TSSK6HSP90AA112383515870294 Affinity Capture-MS
HDAC6HSP90AA110955215916966 15937340 18591380 19158084 Affinity Capture-Western
HDAC6HSP90AA111533015916966 15937340 18591380 19158084 Affinity Capture-Western
COPS3HSP90AA111410316036220 Affinity Capture-MS
COPS3HSP90AA110955216036220 Affinity Capture-MS
SP1HSP90AA111255016118214 Affinity Capture-Western; Reconstituted Complex
SP1HSP90AA110955216118214 Affinity Capture-Western; Reconstituted Complex
HSP90AA1HSP90AA110955216169070 Two-hybrid
RPS3AHSP90AA111210316169070 Two-hybrid
RPS3AHSP90AA110955216169070 Two-hybrid
MGMTHSP90AA111041116226712 Affinity Capture-MS; Affinity Capture-Western
MGMTHSP90AA110955216226712 Affinity Capture-MS; Affinity Capture-Western
UBE2NHSP90AA111318216307917 Reconstituted Complex
UBE2NHSP90AA110955216307917 Reconstituted Complex
RPS6HSP90AA111210816314389 Affinity Capture-Western
RPS6HSP90AA110955216314389 Affinity Capture-Western
RPS3HSP90AA111210216314389 Affinity Capture-Western; Reconstituted Complex
RPS3HSP90AA110955216314389 Affinity Capture-Western; Reconstituted Complex
VCPHSP90AA111325816621797 Affinity Capture-Western
VCPHSP90AA110955216621797 Affinity Capture-Western
MST1RHSP90AA111059216740632 Affinity Capture-Western
MST1RHSP90AA110955216740632 Affinity Capture-Western
RIPK1HSP90AA111427416968706 Affinity Capture-Western
RIPK1HSP90AA110955216968706 Affinity Capture-Western
FNIP1HSP90AA112517517028174 Affinity Capture-MS
FNIP1HSP90AA110955217028174 Affinity Capture-MS
MCF2HSP90AA111033617178836 Reconstituted Complex
MCF2HSP90AA110955217178836 Reconstituted Complex
SIN3AHSP90AA110955217210713 Affinity Capture-Western
SIN3AHSP90AA111743917210713 Affinity Capture-Western
PRMT5HSP90AA110955217409432 Affinity Capture-Western
PRMT5HSP90AA111568817409432 Affinity Capture-Western
SMYD2HSP90AA112127418065756 Affinity Capture-Western
SMYD2HSP90AA110955218065756 Affinity Capture-Western
VEGFAHSP90AA111326518211808 Affinity Capture-Western
VEGFAHSP90AA110955218211808 Affinity Capture-Western
TGFBR1HSP90AA111290418591668 Affinity Capture-Western; Reconstituted Complex
TGFBR1HSP90AA110955218591668 Affinity Capture-Western; Reconstituted Complex
TGFBR2HSP90AA111290618591668 Affinity Capture-Western; Reconstituted Complex
TGFBR2HSP90AA110955218591668 Affinity Capture-Western; Reconstituted Complex
TJP1HSP90AA111293718591668 Reconstituted Complex
TJP1HSP90AA110955218591668 Reconstituted Complex
C8orf41HSP90AA110955220801936 Affinity Capture-MS
C8orf41HSP90AA112316420801936 Affinity Capture-MS
JUNHSP90AA110992820936779 Two-hybrid
JUNHSP90AA110955220936779 Two-hybrid
PAK1HSP90AA111109520936779 Two-hybrid
PAK1HSP90AA110955220936779 Two-hybrid
PRKCZHSP90AA111157620936779 Two-hybrid
PRKCZHSP90AA110955220936779 Two-hybrid
HIST3H3HSP90AA111389520953179 Affinity Capture-MS; Co-purification
HIST3H3HSP90AA110955220953179 Affinity Capture-MS; Co-purification
Gene Symbol Interactant Interaction ID References Description
HSP90AA1ERBB220937915643424 ERBB2 interacts with HSP90. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey HSP90.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
HSP90AA1rs2298877 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:96250
  • Data Attributes: MGI curated and HomoloGene calculated
No data