AutismKB 2.0

Annotation Details for APOA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:APOA1 ( MGC117399 )
Gene Full Name: apolipoprotein A-I
Band: 11q23.3
Quick LinksEntrez ID:335; OMIM: 107680; Uniprot ID:APOA1_HUMAN; ENSEMBL ID: ENSG00000118137; HGNC ID: 600
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space16502470
GO:0005615ISS-extracellular space22261194
GO:0005634IEA-nucleus-
GO:0005769TAS-early endosome-
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0009986IEA-cell surface-
GO:0030139IDA-endocytic vesicle14747463
GO:0031410IDA-cytoplasmic vesicle14703508
GO:0034361IDA-very-low-density lipoprotein particle17154273
GO:0034362IEA-low-density lipoprotein particle-
GO:0034363IEA-intermediate-density lipoprotein particle-
GO:0034364IDA-high-density lipoprotein particle210174
GO:0034365IEA-discoidal high-density lipoprotein particle-
GO:0034366IDA-spherical high-density lipoprotein particle16682745
GO:0034774TAS-secretory granule lumen-
GO:0042627IBA-chylomicron-
GO:0070062IDA-extracellular exosome19056867
GO:0071682TAS-endocytic vesicle lumen-
GO:0072562IDA-blood microparticle22516433
GO:1903561IDA-extracellular vesicle24769233
GO ID Evidence Qualifier GO_term References
GO:0001540IDA-amyloid-beta binding11297421
GO:0001540IPI-amyloid-beta binding9211985
GO:0005515IPI-protein binding11297421
GO:0005543IDA-phospholipid binding12810715
GO:0005548IEA-phospholipid transporter activity-
GO:0008035IEA-high-density lipoprotein particle binding-
GO:0015485IDA-cholesterol binding15464323
GO:0017127IDAcontributes_tocholesterol transporter activity9651324
GO:0017127IMP-cholesterol transporter activity15464323
GO:0019899IPI-enzyme binding1587806
GO:0031072IPI-heat shock protein binding11027668
GO:0031210IBA-phosphatidylcholine binding-
GO:0034190IPI-apolipoprotein receptor binding11162594
GO:0034191IPI-apolipoprotein A-I receptor binding16443932
GO:0042802IPI-identical protein binding8049247
GO:0045499IDA-chemorepellent activity23726972
GO:0055102IEA-lipase inhibitor activity-
GO:0060228IDA-phosphatidylcholine-sterol O-acyltransferase activator activity4335615
GO:0070653IPI-high-density lipoprotein particle receptor binding10764676
GO ID Evidence Qualifier GO_term References
GO:0001523TAS-retinoid metabolic process-
GO:0001932IEA-regulation of protein phosphorylation-
GO:0001935IEA-endothelial cell proliferation-
GO:0002576TAS-platelet degranulation-
GO:0002740IDA-negative regulation of cytokine secretion involved in immune response12458630
GO:0006656IDA-phosphatidylcholine biosynthetic process4335615
GO:0006695IBA-cholesterol biosynthetic process-
GO:0006898TAS-receptor-mediated endocytosis-
GO:0007179IDANOTtransforming growth factor beta receptor signaling pathway23726972
GO:0007186IDA-G-protein coupled receptor signaling pathway16443932
GO:0007229IDA-integrin-mediated signaling pathway23726972
GO:0007584IEA-response to nutrient-
GO:0008203IMP-cholesterol metabolic process15464323
GO:0008211IEA-glucocorticoid metabolic process-
GO:0010804IDA-negative regulation of tumor necrosis factor-mediated signaling pathway21571275
GO:0010873IDA-positive regulation of cholesterol esterification4335615
GO:0010898IBA-positive regulation of triglyceride catabolic process-
GO:0010903IDA-negative regulation of very-low-density lipoprotein particle remodeling14967812
GO:0014012IEA-peripheral nervous system axon regeneration-
GO:0018158IDA-protein oxidation12576517
GO:0018206IDA-peptidyl-methionine modification12576517
GO:0019216TAS-regulation of lipid metabolic process-
GO:0019433IBA-triglyceride catabolic process-
GO:0019915IEA-lipid storage-
GO:0030300IBA-regulation of intestinal cholesterol absorption-
GO:0030301IDA-cholesterol transport10559507
GO:0030325IEA-adrenal gland development-
GO:0031100IEA-animal organ regeneration-
GO:0031102IBA-neuron projection regeneration-
GO:0032489IDA-regulation of Cdc42 protein signal transduction16443932
GO:0033344IDA-cholesterol efflux11162594
GO:0033344IMP-cholesterol efflux12202492
GO:0033700IDA-phospholipid efflux11162594
GO:0034115IDA-negative regulation of heterotypic cell-cell adhesion21571275
GO:0034371TAS-chylomicron remodeling-
GO:0034375IC-high-density lipoprotein particle remodeling4335615
GO:0034375IDA-high-density lipoprotein particle remodeling21481393
GO:0034375TAS-high-density lipoprotein particle remodeling-
GO:0034378TAS-chylomicron assembly-
GO:0034380IDA-high-density lipoprotein particle assembly190223
GO:0034380TAS-high-density lipoprotein particle assembly-
GO:0034384IC-high-density lipoprotein particle clearance12651854
GO:0034384TAS-high-density lipoprotein particle clearance-
GO:0035025IDA-positive regulation of Rho protein signal transduction23726972
GO:0042157IBA-lipoprotein metabolic process-
GO:0042158IEA-lipoprotein biosynthetic process-
GO:0042493IEA-response to drug-
GO:0042632IDA-cholesterol homeostasis21571275
GO:0042632IMP-cholesterol homeostasis15464323
GO:0043534IEA-blood vessel endothelial cell migration-
GO:0043627IEA-response to estrogen-
GO:0043687TAS-post-translational protein modification-
GO:0043691IMP-reverse cholesterol transport15464323
GO:0044267TAS-cellular protein metabolic process-
GO:0045723IBA-positive regulation of fatty acid biosynthetic process-
GO:0050713IDA-negative regulation of interleukin-1 beta secretion12458630
GO:0050728IDA-negative regulation of inflammatory response21571275
GO:0050821IDA-protein stabilization17655203
GO:0050919IDA-negative chemotaxis23726972
GO:0051006IBA-positive regulation of lipoprotein lipase activity-
GO:0051180IMP-vitamin transport15140193
GO:0051345IDA-positive regulation of hydrolase activity7638166
GO:0051496IDA-positive regulation of stress fiber assembly23726972
GO:0055085TAS-transmembrane transport-
GO:0055091IDA-phospholipid homeostasis21571275
GO:0060192IEA-negative regulation of lipase activity-
GO:0060354IDA-negative regulation of cell adhesion molecule production21571275
GO:0060761IDA-negative regulation of response to cytokine stimulus21571275
GO:0070328IDA-triglyceride homeostasis21571275
GO:0070371IDANOTERK1 and ERK2 cascade23726972
GO:0070508IMP-cholesterol import14718538
GO:1900026IDA-positive regulation of substrate adhesion-dependent cell spreading23726972
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
APOA1ABCA110653712084722 Reconstituted Complex
APOA1ABCA110683212084722 Reconstituted Complex
APOA1APOF1068166816269 Co-purification
APOA1APOF1068326816269 Co-purification
LCATAPOA11101231644835 Reconstituted Complex
LCATAPOA11068321644835 Reconstituted Complex
LBPAPOA11101218663389 Affinity Capture-Western
LBPAPOA11068328663389 Affinity Capture-Western
APOL1APOA11141129325276 Co-purification
APOL1APOA11068329325276 Co-purification
APOA1APOA11068329356442 Co-crystal Structure
PLTPAPOA11068329469594 Co-purification; Reconstituted Complex
PLTPAPOA11113749469594 Co-purification; Reconstituted Complex
CD40LGAPOA110739710085035 Affinity Capture-Western
CD40LGAPOA110683210085035 Affinity Capture-Western
GPLD1APOA110908311254757 Affinity Capture-Western; Reconstituted Complex
GPLD1APOA110683211254757 Affinity Capture-Western; Reconstituted Complex
APOA1BPAPOA110683211991719 Affinity Capture-Western
APOA1BPAPOA112610311991719 Affinity Capture-Western
APOC1APOA110683811991719 Two-hybrid
APOC1APOA110683211991719 Two-hybrid
PDE1AAPOA111116211991719 Two-hybrid
PDE1AAPOA110683211991719 Two-hybrid
SAA2APOA111219711991719 Two-hybrid
SAA2APOA110683211991719 Two-hybrid
MAP7D1APOA110683216169070 Two-hybrid
MAP7D1APOA112082516169070 Two-hybrid
TNFRSF10CAPOA110683216169070 Two-hybrid
TNFRSF10CAPOA111432216169070 Two-hybrid
TOMM20APOA110683216169070 Two-hybrid
TOMM20APOA111514416169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APOA1+83/84bp, rs670 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:88049
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-14'