AutismKB 2.0

Annotation Details for HTR1A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HTR1A ( 5-HT1A,5HT1a,ADRB2RL1,ADRBRL1 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 1A
Band: 5q12.3
Quick LinksEntrez ID:3350; OMIM: 109760; Uniprot ID:5HT1A_HUMAN; ENSEMBL ID: ENSG00000178394; HGNC ID: 5286
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane22957663
GO ID Evidence Qualifier GO_term References
GO:0004993IDA-G-protein coupled serotonin receptor activity8393041
GO:0004993IMP-G-protein coupled serotonin receptor activity22957663
GO:0005515IPI-protein binding22035699
GO:0030594IBA-neurotransmitter receptor activity-
GO:0051378IBA-serotonin binding-
GO:0090722IDA-receptor-receptor interaction24157794
GO ID Evidence Qualifier GO_term References
GO:0001662ISS-behavioral fear response-
GO:0007186IMP-G-protein coupled receptor signaling pathway22957663
GO:0007198IDA-adenylate cyclase-inhibiting serotonin receptor signaling pathway8393041
GO:0007210ISS-serotonin receptor signaling pathway-
GO:0008283IEA-cell proliferation-
GO:0008284TAS-positive regulation of cell proliferation1330092
GO:0014062ISS-regulation of serotonin secretion-
GO:0035640ISS-exploration behavior-
GO:0042053ISS-regulation of dopamine metabolic process-
GO:0042310IEA-vasoconstriction-
GO:0042428ISS-serotonin metabolic process-
GO:0046883IEA-regulation of hormone secretion-
GO:0050795IEA-regulation of behavior-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HTR1AS1PR110958211854302 Affinity Capture-Western
HTR1AS1PR110822511854302 Affinity Capture-Western
HTR1AS1PR310958211854302 Affinity Capture-Western
HTR1AS1PR310822711854302 Affinity Capture-Western
HTR1AGPR2610958211854302 Affinity Capture-Western
HTR1AGPR2610910811854302 Affinity Capture-Western
HTR1DHTR1A10958211854302 Affinity Capture-Western
HTR1DHTR1A10958411854302 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
HTR1AHTR1A_C549T, rs1799921, rs1800041, rs1800042, rs6294, rs6295, rs878567 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96273
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-071203-1'