AutismKB 2.0

Annotation Details for HTR2A


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Basic Information Top
Gene Symbol:HTR2A ( 5-HT2A,HTR2 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 2A
Band: 13q14.2
Quick LinksEntrez ID:3356; OMIM: 182135; Uniprot ID:5HT2A_HUMAN; ENSEMBL ID: ENSG00000102468; HGNC ID: 5293
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IEA-cytosol-
GO:0005886IDA-plasma membrane15862800
GO:0005886TAS-plasma membrane-
GO:0005887IEA-integral component of plasma membrane-
GO:0005901IEA-caveola-
GO:0030424IEA-axon-
GO:0031410IEA-cytoplasmic vesicle-
GO:0043025IEA-neuronal cell body-
GO:0043198IEA-dendritic shaft-
GO:0070852IEA-cell body fiber-
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0001965IEA-G-protein alpha-subunit binding-
GO:0004993IDA-G-protein coupled serotonin receptor activity7582481
GO:0008144IDA-drug binding15831837
GO:0030594IBA-neurotransmitter receptor activity-
GO:0032403IEA-protein complex binding-
GO:0051378IDA-serotonin binding7582481
GO:0071886IDA-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding19057895
GO ID Evidence Qualifier GO_term References
GO:0001659IEA-temperature homeostasis-
GO:0006874IDA-cellular calcium ion homeostasis16517693
GO:0007200IBA-phospholipase C-activating G-protein coupled receptor signaling pathway-
GO:0007202IDA-activation of phospholipase C activity16517693
GO:0007208IEA-phospholipase C-activating serotonin receptor signaling pathway-
GO:0007210IMP-serotonin receptor signaling pathway18703043
GO:0007268TAS-chemical synaptic transmission9109547
GO:0007568IEA-aging-
GO:0007613IEA-memory-
GO:0008219IEA-cell death-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0010513IDA-positive regulation of phosphatidylinositol biosynthetic process19057895
GO:0014059IEA-regulation of dopamine secretion-
GO:0014065IDA-phosphatidylinositol 3-kinase signaling16517693
GO:0014824IEA-artery smooth muscle contraction-
GO:0014832IEA-urinary bladder smooth muscle contraction-
GO:0030431IEA-sleep-
GO:0042493IDA-response to drug15862800
GO:0043267IEA-negative regulation of potassium ion transport-
GO:0043406IEA-positive regulation of MAP kinase activity-
GO:0044380IEA-protein localization to cytoskeleton-
GO:0045600IEA-positive regulation of fat cell differentiation-
GO:0045821IEA-positive regulation of glycolytic process-
GO:0045907IEA-positive regulation of vasoconstriction-
GO:0046718IEA-viral entry into host cell-
GO:0046883IEA-regulation of hormone secretion-
GO:0048148IEA-behavioral response to cocaine-
GO:0050731IEA-positive regulation of peptidyl-tyrosine phosphorylation-
GO:0050795IEA-regulation of behavior-
GO:0050965IEA-detection of temperature stimulus involved in sensory perception of pain-
GO:0050966IEA-detection of mechanical stimulus involved in sensory perception of pain-
GO:0051209IDA-release of sequestered calcium ion into cytosol15862800
GO:0051209IMP-release of sequestered calcium ion into cytosol18703043
GO:0051967IEA-negative regulation of synaptic transmission, glutamatergic-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade19057895
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HTR2ADLG410958812682061 Affinity Capture-Western
HTR2ADLG410808612682061 Affinity Capture-Western
JAK2HTR2A1099209169451 Affinity Capture-Western
JAK2HTR2A1095889169451 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
HTR2Ars6311, rs6313 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
HTR2Ars6311, rs6313 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
HTR2AHTR2A_C516T, rs10507544, rs10507546, rs1328684, rs1328685, rs1360020, rs17289304, rs1805055, rs1923882, rs1923884, rs1923886, rs1928040, rs1928042, rs2070036, rs2070037, rs2070040, rs2149434, rs2296972, rs2770296, rs3125, rs3742278, rs3889066, rs4941573, rs582385, rs6305, rs6310, rs6311, rs6312, rs6313, rs6314, rs643627, rs6561333, rs659734, rs677702, rs731244, rs731779, rs7323441, rs7324218, rs7325168, rs7333412, rs7997012, rs912127, rs927544, rs9316233, rs9316235, rs9534505, rs9534511, rs977003, rs985933, rs985934 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109521
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070912-500'