AutismKB 2.0

Annotation Details for APOA2


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Basic Information Top
Gene Symbol:APOA2 ( Apo-AII,ApoA-II,apoAII )
Gene Full Name: apolipoprotein A-II
Band: 1q23.3
Quick LinksEntrez ID:336; OMIM: 107670; Uniprot ID:APOA2_HUMAN; ENSEMBL ID: ENSG00000158874; HGNC ID: 601
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005769TAS-early endosome-
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005829TAS-cytosol-
GO:0034361IDA-very-low-density lipoprotein particle8245722
GO:0034364IDA-high-density lipoprotein particle210174
GO:0034366IDA-spherical high-density lipoprotein particle16682745
GO:0042627IDA-chylomicron8245722
GO:0070062IDA-extracellular exosome19056867
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0005319IDA-lipid transporter activity1606170
GO:0005515IPI-protein binding11991719
GO:0005543IDA-phospholipid binding218942
GO:0008035IEA-high-density lipoprotein particle binding-
GO:0008289IDA-lipid binding14967812
GO:0015485IDA-cholesterol binding218942
GO:0017127IDAcontributes_tocholesterol transporter activity9651324
GO:0031072IPI-heat shock protein binding11027668
GO:0031210IDA-phosphatidylcholine binding17264082
GO:0034190IPI-apolipoprotein receptor binding11162594
GO:0042803IDA-protein homodimerization activity17264082
GO:0046982IPI-protein heterodimerization activity7918467
GO:0055102IDA-lipase inhibitor activity14967812
GO:0060228IDA-phosphatidylcholine-sterol O-acyltransferase activator activity14967812
GO:0070653IPI-high-density lipoprotein particle receptor binding10764676
GO ID Evidence Qualifier GO_term References
GO:0001523TAS-retinoid metabolic process-
GO:0002526IEA-acute inflammatory response-
GO:0002740IDA-negative regulation of cytokine secretion involved in immune response12458630
GO:0006641TAS-triglyceride metabolic process11551871
GO:0006656IDA-phosphatidylcholine biosynthetic process14967812
GO:0008203IEA-cholesterol metabolic process-
GO:0009395IDA-phospholipid catabolic process14967812
GO:0009749IDA-response to glucose14988251
GO:0010873IDA-positive regulation of cholesterol esterification14967812
GO:0010903IDA-negative regulation of very-low-density lipoprotein particle remodeling14967812
GO:0016032IEA-viral process-
GO:0018158IDA-protein oxidation12576517
GO:0018206IDA-peptidyl-methionine modification12576517
GO:0019216TAS-regulation of lipid metabolic process-
GO:0030300IEA-regulation of intestinal cholesterol absorption-
GO:0031100IEA-animal organ regeneration-
GO:0031647IDA-regulation of protein stability14967812
GO:0032375IMP-negative regulation of cholesterol transport8636092
GO:0033344IDA-cholesterol efflux11162594
GO:0033700IDA-phospholipid efflux11162594
GO:0034370IDA-triglyceride-rich lipoprotein particle remodeling14967812
GO:0034371TAS-chylomicron remodeling-
GO:0034374IDA-low-density lipoprotein particle remodeling8106353
GO:0034375IDA-high-density lipoprotein particle remodeling8106353
GO:0034378TAS-chylomicron assembly-
GO:0034380IDA-high-density lipoprotein particle assembly218942
GO:0034384IDA-high-density lipoprotein particle clearance10764676
GO:0042157IEA-lipoprotein metabolic process-
GO:0042493IEA-response to drug-
GO:0042632IDA-cholesterol homeostasis14967812
GO:0043085IEA-positive regulation of catalytic activity-
GO:0043627IEA-response to estrogen-
GO:0043687TAS-post-translational protein modification-
GO:0043691IDA-reverse cholesterol transport14967812
GO:0044267TAS-cellular protein metabolic process-
GO:0045416IDA-positive regulation of interleukin-8 biosynthetic process11591715
GO:0046340IDA-diacylglycerol catabolic process14967812
GO:0050995IDA-negative regulation of lipid catabolic process14967812
GO:0050996IDA-positive regulation of lipid catabolic process8640403
GO:0051384IEA-response to glucocorticoid-
GO:0060192IDA-negative regulation of lipase activity14967812
GO:0060621IDA-negative regulation of cholesterol import10764676
GO:0060695IDA-negative regulation of cholesterol transporter activity8106353
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
APOA2APOF1068336816269 Co-purification
APOA2APOF1068166816269 Co-purification
APODAPOA21068337918467 Co-purification
APODAPOA21068447918467 Co-purification
PLTPAPOA21068339469594 Co-purification; Reconstituted Complex
PLTPAPOA21113749469594 Co-purification; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APOA2rs5082 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:88050
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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