AutismKB 2.0

Annotation Details for HTR4


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Basic Information Top
Gene Symbol:HTR4 ( 5-HT4,5-HT4R )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 4
Band: 5q32
Quick LinksEntrez ID:3360; OMIM: 602164; Uniprot ID:5HT4R_HUMAN; ENSEMBL ID: ENSG00000164270; HGNC ID: 5299
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm15925089
GO:0005768IEA-endosome-
GO:0005886TAS-plasma membrane-
GO:0005887IEA-integral component of plasma membrane-
GO:0016020IDA-membrane16102731
GO ID Evidence Qualifier GO_term References
GO:0001594IBA-trace-amine receptor activity-
GO:0004993IDA-G-protein coupled serotonin receptor activity16102731
GO ID Evidence Qualifier GO_term References
GO:0007186TAS-G-protein coupled receptor signaling pathway9351641
GO:0007187TAS-G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger9603189
GO:0007214IBA-gamma-aminobutyric acid signaling pathway-
GO:0007268IEA-chemical synaptic transmission-
GO:0032098IEA-regulation of appetite-
GO:0098664IEA-G-protein coupled serotonin receptor signaling pathway-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
HTR4HTR4_26+14T/C, HTR4_IVS1+15T/C, HTR4_d-25T/C, HTR4_g.83097C/T, HTR4_g.83159G/A, HTR4_g.83164T9-10, HTR4_g.83198A/G, rs10051356, rs10078551, rs13182501, rs1422636, rs1432919, rs2068190, rs2278392, rs3734119, rs5028114, rs6873382, rs7711800, rs7713886, rs7715569, rs9325104 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109246
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018