AutismKB 2.0

Annotation Details for APOB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:APOB ( FLDB,LDLCQ4 )
Gene Full Name: apolipoprotein B (including Ag(x) antigen)
Band: 2p24.1
Quick LinksEntrez ID:338; OMIM: 107730; Uniprot ID:APOB_HUMAN; ENSEMBL ID: ENSG00000084674; HGNC ID: 603
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615ISS-extracellular space22261194
GO:0005737IDA-cytoplasm22580899
GO:0005769TAS-early endosome-
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005790TAS-smooth endoplasmic reticulum-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0010008TAS-endosome membrane-
GO:0030669TAS-clathrin-coated endocytic vesicle membrane-
GO:0031904TAS-endosome lumen-
GO:0034359IDA-mature chylomicron4363408
GO:0034360TAS-chylomicron remnant6099394
GO:0034361IDA-very-low-density lipoprotein particle4363408
GO:0034362IDA-low-density lipoprotein particle4363408
GO:0034363IDA-intermediate-density lipoprotein particle1917954
GO:0042627IDA-chylomicron4363408
GO:0043025IDA-neuronal cell body22897442
GO:0043202TAS-lysosomal lumen-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0070062IDA-extracellular exosome23533145
GO:0070971IDA-endoplasmic reticulum exit site27138255
GO:0071682TAS-endocytic vesicle lumen-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding8245722
GO:0005543IDA-phospholipid binding7126555
GO:0008201IDA-heparin binding16233946
GO:0017127IMP-cholesterol transporter activity15797858
GO:0035473IPI-lipase binding9685400
GO:0050750IMP-low-density lipoprotein particle receptor binding2563166
GO ID Evidence Qualifier GO_term References
GO:0001523TAS-retinoid metabolic process-
GO:0001701IEA-in utero embryonic development-
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0006642IEA-triglyceride mobilization-
GO:0006898TAS-receptor-mediated endocytosis-
GO:0007283IEA-spermatogenesis-
GO:0007399IEA-nervous system development-
GO:0008203IMP-cholesterol metabolic process2563166
GO:0009566IEA-fertilization-
GO:0009615IEP-response to virus16548883
GO:0009743IEA-response to carbohydrate-
GO:0009791IEA-post-embryonic development-
GO:0010269IEA-response to selenium ion-
GO:0010628IEA-positive regulation of gene expression-
GO:0010744IDA-positive regulation of macrophage derived foam cell differentiation17244792
GO:0010884IDA-positive regulation of lipid storage18322245
GO:0010886IDA-positive regulation of cholesterol storage19114110
GO:0019433IEA-triglyceride catabolic process-
GO:0030301IMP-cholesterol transport2563166
GO:0030317IEA-flagellated sperm motility-
GO:0032355IEA-response to estradiol-
GO:0032496IEA-response to lipopolysaccharide-
GO:0033344IEA-cholesterol efflux-
GO:0034371TAS-chylomicron remodeling-
GO:0034374IMP-low-density lipoprotein particle remodeling15797858
GO:0034374TAS-low-density lipoprotein particle remodeling-
GO:0034378TAS-chylomicron assembly-
GO:0034379IC-very-low-density lipoprotein particle assembly15308631
GO:0034379TAS-very-low-density lipoprotein particle assembly-
GO:0034382TAS-chylomicron remnant clearance-
GO:0034383IMP-low-density lipoprotein particle clearance2563166
GO:0034383TAS-low-density lipoprotein particle clearance-
GO:0034447TAS-very-low-density lipoprotein particle clearance-
GO:0042158IEA-lipoprotein biosynthetic process-
GO:0042159IEA-lipoprotein catabolic process-
GO:0042632IMP-cholesterol homeostasis2563166
GO:0042953IEA-lipoprotein transport-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0045540IEA-regulation of cholesterol biosynthetic process-
GO:0048844IEA-artery morphogenesis-
GO:0050900TAS-leukocyte migration-
GO:0061024TAS-membrane organization-
GO:0071356IEA-cellular response to tumor necrosis factor-
GO:0071379IEA-cellular response to prostaglandin stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SEC61BAPOB1068359565615 Affinity Capture-Western
SEC61BAPOB1161529565615 Affinity Capture-Western
SEC61A1APOB1189689565615 Affinity Capture-Western
SEC61A1APOB1068359565615 Affinity Capture-Western
LIPCAPOB1068359685400 Reconstituted Complex
LIPCAPOB1101789685400 Reconstituted Complex
HSP90B1APOB1068359694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
HSP90B1APOB1130369694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
CALCRAPOB1072509694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
CALCRAPOB1068359694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
PDIA4APOB1149669694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
PDIA4APOB1068359694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
MTTPAPOB1068359915855 Two-hybrid
MTTPAPOB1106419915855 Two-hybrid
CALRAPOB10683510513896 Affinity Capture-Western
CALRAPOB10726210513896 Affinity Capture-Western
BGNAPOB10683512070165 Reconstituted Complex
BGNAPOB10710212070165 Reconstituted Complex
PPIBAPOB11147512397072 Affinity Capture-Western; Co-fractionation
PPIBAPOB10683512397072 Affinity Capture-Western; Co-fractionation
CANXAPOB10727114498830 Affinity Capture-Western
CANXAPOB10683514498830 Affinity Capture-Western
UBCAPOB11316415618547 Affinity Capture-Western
UBCAPOB10683515618547 Affinity Capture-Western
LRP6APOB11021918948618 Reconstituted Complex
LRP6APOB10683518948618 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APOBAPOB_9bpindel, APOB_EcoRI, APOB_XbaI Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
APOBrs1042031, rs693 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:88052
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070702-4'