Gene Symbol:	ICAM1 ( BB2,CD54,P3.58 )
Gene Full Name:	intercellular adhesion molecule 1
Band:	19p13.2
Quick Links	Entrez ID:3383; OMIM: 147840; Uniprot ID:ICAM1_HUMAN; ENSEMBL ID: ENSG00000090339; HGNC ID: 5344
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0001772	IEA	-	immunological synapse	-
GO:0005615	IDA	-	extracellular space	9290466
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	TAS	-	integral component of plasma membrane	2538243
GO:0005925	IDA	-	focal adhesion	21423176
GO:0009897	IEA	-	external side of plasma membrane	-
GO:0009986	IDA	-	cell surface	19581412
GO:0016020	IDA	-	membrane	19946888
GO:0045121	IEA	-	membrane raft	-
GO:0070062	IDA	-	extracellular exosome	19056867

GO ID	Evidence	Qualifier	GO_term	References
GO:0001618	IEA	-	virus receptor activity	-
GO:0004872	TAS	-	receptor activity	2538243
GO:0004888	TAS	-	transmembrane signaling receptor activity	2538243
GO:0005178	IDA	-	integrin binding	23620790
GO:0005178	IPI	-	integrin binding	1448173
GO:0005515	IPI	-	protein binding	7822297

GO ID	Evidence	Qualifier	GO_term	References
GO:0001541	IEA	-	ovarian follicle development	-
GO:0001910	TAS	-	regulation of leukocyte mediated cytotoxicity	16038038
GO:0001975	IEA	-	response to amphetamine	-
GO:0002291	IMP	-	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	2477710
GO:0002438	IEA	-	acute inflammatory response to antigenic stimulus	-
GO:0002457	IEA	-	T cell antigen processing and presentation	-
GO:0002693	IMP	-	positive regulation of cellular extravasation	12902516
GO:0007155	IDA	-	cell adhesion	16809613
GO:0007157	TAS	-	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	2477710
GO:0007159	IMP	-	leukocyte cell-cell adhesion	2477710
GO:0007569	IEA	-	cell aging	-
GO:0007605	IEA	-	sensory perception of sound	-
GO:0008360	IEA	-	regulation of cell shape	-
GO:0010212	IEA	-	response to ionizing radiation	-
GO:0010477	IEA	-	response to sulfur dioxide	-
GO:0022614	IEP	-	membrane to membrane docking	12082081
GO:0030198	TAS	-	extracellular matrix organization	-
GO:0030838	IEA	-	positive regulation of actin filament polymerization	-
GO:0031669	IEA	-	cellular response to nutrient levels	-
GO:0032868	IEA	-	response to insulin	-
GO:0033627	IEA	-	cell adhesion mediated by integrin	-
GO:0034698	IEA	-	response to gonadotropin	-
GO:0042493	IEA	-	response to drug	-
GO:0043200	IEA	-	response to amino acid	-
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0044406	IDA	-	adhesion of symbiont to host	2538243
GO:0045429	IEA	-	positive regulation of nitric oxide biosynthetic process	-
GO:0045471	IEA	-	response to ethanol	-
GO:0045907	IEA	-	positive regulation of vasoconstriction	-
GO:0046688	IEA	-	response to copper ion	-
GO:0046718	IEA	-	viral entry into host cell	-
GO:0046813	IDA	-	receptor-mediated virion attachment to host cell	2538243
GO:0050731	IEA	-	positive regulation of peptidyl-tyrosine phosphorylation	-
GO:0050776	TAS	-	regulation of immune response	-
GO:0050900	IEP	-	leukocyte migration	12082081
GO:0051092	IEA	-	positive regulation of NF-kappaB transcription factor activity	-
GO:0051926	IEA	-	negative regulation of calcium ion transport	-
GO:0060333	TAS	-	interferon-gamma-mediated signaling pathway	-
GO:0061028	IGI	-	establishment of endothelial barrier	23264465
GO:0070374	IMP	-	positive regulation of ERK1 and ERK2 cascade	10903502
GO:0071222	IEA	-	cellular response to lipopolysaccharide	-
GO:0071312	IEA	-	cellular response to alkaloid	-
GO:0071333	IEA	-	cellular response to glucose stimulus	-
GO:0071347	IEA	-	cellular response to interleukin-1	-
GO:0071354	IEA	-	cellular response to interleukin-6	-
GO:0071356	IEA	-	cellular response to tumor necrosis factor	-
GO:0071456	IEA	-	cellular response to hypoxia	-
GO:0071549	IEA	-	cellular response to dexamethasone stimulus	-
GO:0090557	IEA	-	establishment of endothelial intestinal barrier	-
GO:0097368	IEA	-	establishment of Sertoli cell barrier	-
GO:1900027	IEA	-	regulation of ruffle assembly	-
GO:1902042	IDA	-	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	10903502
GO:1904996	IEA	-	positive regulation of leukocyte adhesion to vascular endothelial cell	-
GO:2000352	IDA	-	negative regulation of endothelial cell apoptotic process	10903502

Gene Symbol	Interactant	Interaction ID	References	Description
IL2RA	ICAM1	109774	1976256	Affinity Capture-Western
IL2RA	ICAM1	109610	1976256	Affinity Capture-Western
ITGB2	ICAM1	109895	7642561 10352278 11279101	Reconstituted Complex
ITGB2	ICAM1	109610	7642561 10352278 11279101	Reconstituted Complex
EZR	ICAM1	113271	9705328	Affinity Capture-Western; Reconstituted Complex
EZR	ICAM1	109610	9705328	Affinity Capture-Western; Reconstituted Complex
ITGAL	ICAM1	109889	11279101 11786177 12526797	Co-crystal Structure; Reconstituted Complex
ITGAL	ICAM1	109610	11279101 11786177 12526797	Co-crystal Structure; Reconstituted Complex
ITGAM	ICAM1	109890	12208882	Reconstituted Complex
ITGAM	ICAM1	109610	12208882	Reconstituted Complex

AutismKB 2.0

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