AutismKB 2.0

Annotation Details for APOC1


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Basic Information Top
Gene Symbol:APOC1 ( - )
Gene Full Name: apolipoprotein C-I
Band: 19q13.32
Quick LinksEntrez ID:341; OMIM: 107710; Uniprot ID:APOC1_HUMAN; ENSEMBL ID: ENSG00000130208; HGNC ID: 607
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005783IDA-endoplasmic reticulum-
GO:0034361IDA-very-low-density lipoprotein particle15576844
GO:0034364IDA-high-density lipoprotein particle15576844
GO:0042627TAS-chylomicron18992221
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004859IDA-phospholipase inhibitor activity2302419
GO:0005504IDA-fatty acid binding17339654
GO:0031210TAS-phosphatidylcholine binding2302419
GO:0055102IDA-lipase inhibitor activity182536
GO:0060228TAS-phosphatidylcholine-sterol O-acyltransferase activator activity18992221
GO ID Evidence Qualifier GO_term References
GO:0006629TAS-lipid metabolic process2897845
GO:0006641IEA-triglyceride metabolic process-
GO:0008203IEA-cholesterol metabolic process-
GO:0010873TAS-positive regulation of cholesterol esterification18992221
GO:0010900IDA-negative regulation of phosphatidylcholine catabolic process2302419
GO:0010916IDA-negative regulation of very-low-density lipoprotein particle clearance1917954
GO:0032374IC-regulation of cholesterol transport15576844
GO:0032375IDA-negative regulation of cholesterol transport10978346
GO:0033344IDA-cholesterol efflux11162594
GO:0033700IDA-phospholipid efflux11162594
GO:0034369IDA-plasma lipoprotein particle remodeling10978346
GO:0034375TAS-high-density lipoprotein particle remodeling18992221
GO:0034379TAS-very-low-density lipoprotein particle assembly18992221
GO:0034382IDA-chylomicron remnant clearance4020294
GO:0034447IGI-very-low-density lipoprotein particle clearance15576844
GO:0034447TAS-very-low-density lipoprotein particle clearance-
GO:0042157IEA-lipoprotein metabolic process-
GO:0043085IEA-positive regulation of catalytic activity-
GO:0045717IDA-negative regulation of fatty acid biosynthetic process15576844
GO:0045833IDA-negative regulation of lipid metabolic process182536
GO:0048261IDA-negative regulation of receptor-mediated endocytosis1917954
GO:0050995IDA-negative regulation of lipid catabolic process15576844
GO:0051005IDA-negative regulation of lipoprotein lipase activity15576844
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
APOC1APOA110683811991719 Two-hybrid
APOC1APOA110683211991719 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APOC1rs11568822, rs3826688, rs4420638, rs445925, rs4803770, rs483082, rs584007, rs7256200, rs7259004 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:88053
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018