AutismKB 2.0

Annotation Details for APOC3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:APOC3 ( APOCIII,MGC150353 )
Gene Full Name: apolipoprotein C-III
Band: 11q23.3
Quick LinksEntrez ID:345; OMIM: 107720; Uniprot ID:APOC3_HUMAN; ENSEMBL ID: ENSG00000110245; HGNC ID: 610
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space11060345
GO:0005769TAS-early endosome-
GO:0034361IDA-very-low-density lipoprotein particle3973011
GO:0034363IDA-intermediate-density lipoprotein particle17336988
GO:0034366IDA-spherical high-density lipoprotein particle17438339
GO:0042627IDA-chylomicron8245722
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0005543IDA-phospholipid binding4066713
GO:0015485IC-cholesterol binding11162594
GO:0030234IDA-enzyme regulator activity11060345
GO:0055102IDA-lipase inhibitor activity182536
GO:0070653IPI-high-density lipoprotein particle receptor binding9254056
GO ID Evidence Qualifier GO_term References
GO:0001523TAS-retinoid metabolic process-
GO:0006641IMP-triglyceride metabolic process17142127
GO:0007186IDA-G-protein coupled receptor signaling pathway16443932
GO:0010897IDA-negative regulation of triglyceride catabolic process3973011
GO:0010903IC-negative regulation of very-low-density lipoprotein particle remodeling18635818
GO:0010903IDA-negative regulation of very-low-density lipoprotein particle remodeling3973011
GO:0010916IDA-negative regulation of very-low-density lipoprotein particle clearance1917954
GO:0010987IMP-negative regulation of high-density lipoprotein particle clearance15778093
GO:0010989IMP-negative regulation of low-density lipoprotein particle clearance15778093
GO:0019433IDA-triglyceride catabolic process11060345
GO:0032489IDA-regulation of Cdc42 protein signal transduction16443932
GO:0033344IDA-cholesterol efflux11162594
GO:0033700IDA-phospholipid efflux11162594
GO:0034371TAS-chylomicron remodeling-
GO:0034375IMP-high-density lipoprotein particle remodeling17438339
GO:0034375TAS-high-density lipoprotein particle remodeling-
GO:0034378TAS-chylomicron assembly-
GO:0034379TAS-very-low-density lipoprotein particle assembly18399797
GO:0034382IDA-chylomicron remnant clearance4020294
GO:0042157IEA-lipoprotein metabolic process-
GO:0042632IMP-cholesterol homeostasis18767813
GO:0043691IC-reverse cholesterol transport17438339
GO:0045717IDA-negative regulation of fatty acid biosynthetic process11060345
GO:0045833IDA-negative regulation of lipid metabolic process182536
GO:0048261IDA-negative regulation of receptor-mediated endocytosis1917954
GO:0050995IDA-negative regulation of lipid catabolic process15576844
GO:0051005IDA-negative regulation of lipoprotein lipase activity3973011
GO:0060621IMP-negative regulation of cholesterol import15778093
GO:0070328IMP-triglyceride homeostasis18767813
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APOC3rs5128 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:88055
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved