Gene Symbol:	IFNG ( IFG,IFI )
Gene Full Name:	interferon, gamma
Band:	12q15
Quick Links	Entrez ID:3458; OMIM: 147570; Uniprot ID:IFNG_HUMAN; ENSEMBL ID: ENSG00000111537; HGNC ID: 5438
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	IDA	-	extracellular region	20041150
GO:0005576	TAS	-	extracellular region	-
GO:0005615	IEA	-	extracellular space	-
GO:0005737	IEA	-	cytoplasm	-
GO:0009897	IEA	-	external side of plasma membrane	-
GO:0043005	IEA	-	neuron projection	-
GO:0043204	IEA	-	perikaryon	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005125	IEA	-	cytokine activity	-
GO:0005133	IEA	-	interferon-gamma receptor binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000060	IDA	-	protein import into nucleus, translocation	15604419
GO:0000122	ISS	-	negative regulation of transcription from RNA polymerase II promoter	-
GO:0001781	IEA	-	neutrophil apoptotic process	-
GO:0001934	IDA	-	positive regulation of protein phosphorylation	22504299
GO:0002026	IEA	-	regulation of the force of heart contraction	-
GO:0002250	IEA	-	adaptive immune response	-
GO:0002302	IEA	-	CD8-positive, alpha-beta T cell differentiation involved in immune response	-
GO:0006915	IGI	-	apoptotic process	7828849
GO:0006928	TAS	-	movement of cell or subcellular component	10477596
GO:0006959	IEA	-	humoral immune response	-
GO:0007050	IDA	-	cell cycle arrest	16942485
GO:0007166	TAS	-	cell surface receptor signaling pathway	10477596
GO:0008284	ISS	-	positive regulation of cell proliferation	-
GO:0009615	IDA	-	response to virus	16280321
GO:0010508	IDA	-	positive regulation of autophagy	23629966
GO:0010628	IDA	-	positive regulation of gene expression	11487543
GO:0010629	IDA	-	negative regulation of gene expression	23817958
GO:0010634	IDA	-	positive regulation of epithelial cell migration	11698262
GO:0010835	IDA	-	regulation of protein ADP-ribosylation	22504299
GO:0019882	IEA	-	antigen processing and presentation	-
GO:0030593	IEA	-	neutrophil chemotaxis	-
GO:0030857	ISS	-	negative regulation of epithelial cell differentiation	-
GO:0030968	IEA	-	endoplasmic reticulum unfolded protein response	-
GO:0031334	IDA	-	positive regulation of protein complex assembly	22504299
GO:0031642	IEA	-	negative regulation of myelination	-
GO:0032224	IEA	-	positive regulation of synaptic transmission, cholinergic	-
GO:0032700	IDA	-	negative regulation of interleukin-17 production	18501882
GO:0032735	IDA	-	positive regulation of interleukin-12 production	7605994
GO:0032747	IDA	-	positive regulation of interleukin-23 production	20027291
GO:0032760	IEA	-	positive regulation of tumor necrosis factor production	-
GO:0032834	IDA	-	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	20209097
GO:0033141	IDA	-	positive regulation of peptidyl-serine phosphorylation of STAT protein	16280321
GO:0033141	NAS	-	positive regulation of peptidyl-serine phosphorylation of STAT protein	21268089
GO:0033160	IDA	-	positive regulation of protein import into nucleus, translocation	22504299
GO:0034393	IDA	-	positive regulation of smooth muscle cell apoptotic process	16942485
GO:0042102	IEA	-	positive regulation of T cell proliferation	-
GO:0042493	IEA	-	response to drug	-
GO:0042531	IDA	-	positive regulation of tyrosine phosphorylation of STAT protein	15604419
GO:0042742	IEA	-	defense response to bacterium	-
GO:0042832	IEA	-	defense response to protozoan	-
GO:0044130	IEA	-	negative regulation of growth of symbiont in host	-
GO:0045080	IEA	-	positive regulation of chemokine biosynthetic process	-
GO:0045084	IEA	-	positive regulation of interleukin-12 biosynthetic process	-
GO:0045348	IEA	-	positive regulation of MHC class II biosynthetic process	-
GO:0045410	IEA	-	positive regulation of interleukin-6 biosynthetic process	-
GO:0045429	IDA	-	positive regulation of nitric oxide biosynthetic process	8383325
GO:0045666	IEA	-	positive regulation of neuron differentiation	-
GO:0045672	IDA	-	positive regulation of osteoclast differentiation	16220542
GO:0045892	IDA	-	negative regulation of transcription, DNA-templated	23629966
GO:0045944	IEA	-	positive regulation of transcription from RNA polymerase II promoter	-
GO:0048147	IEA	-	negative regulation of fibroblast proliferation	-
GO:0048304	IEA	-	positive regulation of isotype switching to IgG isotypes	-
GO:0048662	IDA	-	negative regulation of smooth muscle cell proliferation	16942485
GO:0050691	IEA	-	regulation of defense response to virus by host	-
GO:0050718	IEA	-	positive regulation of interleukin-1 beta secretion	-
GO:0050796	IDA	-	regulation of insulin secretion	8383325
GO:0050852	IEA	-	T cell receptor signaling pathway	-
GO:0050954	IEA	-	sensory perception of mechanical stimulus	-
GO:0051044	IDA	-	positive regulation of membrane protein ectodomain proteolysis	18373975
GO:0051607	IEA	-	defense response to virus	-
GO:0051712	IDA	-	positive regulation of killing of cells of other organism	7544003
GO:0060251	IEA	-	regulation of glial cell proliferation	-
GO:0060333	IDA	-	interferon-gamma-mediated signaling pathway	22504299
GO:0060333	TAS	-	interferon-gamma-mediated signaling pathway	-
GO:0060334	TAS	-	regulation of interferon-gamma-mediated signaling pathway	-
GO:0060550	IDA	-	positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	9282826
GO:0060552	IDA	-	positive regulation of fructose 1,6-bisphosphate metabolic process	9282826
GO:0060557	IDA	-	positive regulation of vitamin D biosynthetic process	9282826
GO:0060559	IDA	-	positive regulation of calcidiol 1-monooxygenase activity	9282826
GO:0071222	IEA	-	cellular response to lipopolysaccharide	-
GO:0071351	IEA	-	cellular response to interleukin-18	-
GO:0071902	IDA	-	positive regulation of protein serine/threonine kinase activity	22504299
GO:0072125	IEA	-	negative regulation of glomerular mesangial cell proliferation	-
GO:0090004	IDA	-	positive regulation of establishment of protein localization to plasma membrane	11487543
GO:0090312	IDA	-	positive regulation of protein deacetylation	23629966
GO:0097191	IDA	-	extrinsic apoptotic signaling pathway	16942485
GO:0098908	IEA	-	regulation of neuronal action potential	-
GO:1903543	IDA	-	positive regulation of exosomal secretion	11487543
GO:1904798	IDA	-	positive regulation of core promoter binding	23629966
GO:2000309	IDA	-	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	16220542
GO:2000345	IEA	-	regulation of hepatocyte proliferation	-

Gene Symbol	Interactant	Interaction ID	References	Description
IFNGR1	IFNG	109680	7673114 10986460	Co-crystal Structure; Reconstituted Complex
IFNGR1	IFNG	109681	7673114 10986460	Co-crystal Structure; Reconstituted Complex
IFNGR2	IFNG	109680	7673114	Reconstituted Complex
IFNGR2	IFNG	109682	7673114	Reconstituted Complex
IFNG	IFNG	109680	10986460	Co-crystal Structure

AutismKB 2.0

Annotation Details for IFNG