AutismKB 2.0

Annotation Details for APOE


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Basic Information Top
Gene Symbol:APOE ( AD2,LDLCQ5,LPG,MGC1571 )
Gene Full Name: apolipoprotein E
Band: 19q13.32
Quick LinksEntrez ID:348; OMIM: 107741; Uniprot ID:APOE_HUMAN; ENSEMBL ID: ENSG00000130203; HGNC ID: 613
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region8089103
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space16502470
GO:0005634IDA-nucleus21630459
GO:0005737NAS-cytoplasm8083695
GO:0005737TAS-cytoplasm9622609
GO:0005769TAS-early endosome-
GO:0005783IDA-endoplasmic reticulum25122793
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005794IDA-Golgi apparatus25122793
GO:0005886TAS-plasma membrane-
GO:0016020IDA-membrane19946888
GO:0030425NAS-dendrite8083695
GO:0030669TAS-clathrin-coated endocytic vesicle membrane-
GO:0031012IDA-extracellular matrix23658023
GO:0034361IDA-very-low-density lipoprotein particle8245722
GO:0034362IDA-low-density lipoprotein particle8245722
GO:0034363IDA-intermediate-density lipoprotein particle9211985
GO:0034364IDA-high-density lipoprotein particle210174
GO:0042627IDA-chylomicron8245722
GO:0043025NAS-neuronal cell body8083695
GO:0070062IDA-extracellular exosome19056867
GO:0071682TAS-endocytic vesicle lumen-
GO:0072562IDA-blood microparticle22516433
GO:1903561IDA-extracellular vesicle24769233
GO:1990777IDA-lipoprotein particle22138302
GO ID Evidence Qualifier GO_term References
GO:0001540IDA-amyloid-beta binding8089103
GO:0001540IPI-amyloid-beta binding9003062
GO:0005198TAS-structural molecule activity22138302
GO:0005319IDA-lipid transporter activity17305370
GO:0005515IPI-protein binding7972031
GO:0005543IDA-phospholipid binding4066713
GO:0008201IDA-heparin binding2745454
GO:0008289IDA-lipid binding4066713
GO:0015485IBA-cholesterol binding-
GO:0016209IDA-antioxidant activity9685360
GO:0017127IBA-cholesterol transporter activity-
GO:0042802IDA-identical protein binding4066713
GO:0042803IDA-protein homodimerization activity8089103
GO:0042803IPI-protein homodimerization activity8245722
GO:0046911IDA-metal chelating activity9685360
GO:0046983IDA-protein dimerization activity22138302
GO:0048156IPI-tau protein binding7566652
GO:0050750IDA-low-density lipoprotein particle receptor binding210175
GO:0050750IPI-low-density lipoprotein particle receptor binding17326667
GO:0060228IDA-phosphatidylcholine-sterol O-acyltransferase activator activity15654758
GO:0070326IDA-very-low-density lipoprotein particle receptor binding1384047
GO:0070326IPI-very-low-density lipoprotein particle receptor binding12950167
GO:0071813IEA-lipoprotein particle binding-
GO ID Evidence Qualifier GO_term References
GO:0000302NAS-response to reactive oxygen species11743999
GO:0001523TAS-retinoid metabolic process-
GO:0001937IDA-negative regulation of endothelial cell proliferation9685360
GO:0002021IEA-response to dietary excess-
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter-
GO:0006641IDA-triglyceride metabolic process9649566
GO:0006641IMP-triglyceride metabolic process3771793
GO:0006707IBA-cholesterol catabolic process-
GO:0006874IEA-cellular calcium ion homeostasis-
GO:0006898IDA-receptor-mediated endocytosis1917954
GO:0006898TAS-receptor-mediated endocytosis22138302
GO:0007010TAS-cytoskeleton organization9622609
GO:0007186IDA-G-protein coupled receptor signaling pathway16443932
GO:0007263IDA-nitric oxide mediated signal transduction8995232
GO:0007271TAS-synaptic transmission, cholinergic9622609
GO:0008203IDA-cholesterol metabolic process9649566
GO:0008203IMP-cholesterol metabolic process3771793
GO:0010544IDA-negative regulation of platelet activation8995232
GO:0010873IDA-positive regulation of cholesterol esterification15654758
GO:0010875IDA-positive regulation of cholesterol efflux12042316
GO:0010875IGI-positive regulation of cholesterol efflux12401887
GO:0010877ISS-lipid transport involved in lipid storage-
GO:0010976IDA-positive regulation of neuron projection development7592957
GO:0010976ISS-positive regulation of neuron projection development-
GO:0010977IDA-negative regulation of neuron projection development7592957
GO:0015909IDA-long-chain fatty acid transport24345162
GO:0017038IDA-protein import24446231
GO:0019068IMP-virion assembly25122793
GO:0019433IBA-triglyceride catabolic process-
GO:0019934IDA-cGMP-mediated signaling8995232
GO:0030195IDA-negative regulation of blood coagulation8995232
GO:0030516TAS-regulation of axon extension9622609
GO:0030828IDA-positive regulation of cGMP biosynthetic process8995232
GO:0031102IBA-neuron projection regeneration-
GO:0032269IGI-negative regulation of cellular protein metabolic process16805831
GO:0032489IDA-regulation of Cdc42 protein signal transduction16443932
GO:0032805IDA-positive regulation of low-density lipoprotein particle receptor catabolic process15950758
GO:0033344IDA-cholesterol efflux11162594
GO:0033700IDA-phospholipid efflux11162594
GO:0034371TAS-chylomicron remodeling-
GO:0034372IDA-very-low-density lipoprotein particle remodeling15654758
GO:0034372IGI-very-low-density lipoprotein particle remodeling12401887
GO:0034374IEA-low-density lipoprotein particle remodeling-
GO:0034375IGI-high-density lipoprotein particle remodeling12401887
GO:0034375TAS-high-density lipoprotein particle remodeling-
GO:0034378TAS-chylomicron assembly-
GO:0034380IDA-high-density lipoprotein particle assembly17305370
GO:0034382IMP-chylomicron remnant clearance7175379
GO:0034382TAS-chylomicron remnant clearance-
GO:0034384IDA-high-density lipoprotein particle clearance210175
GO:0034447IDA-very-low-density lipoprotein particle clearance1917954
GO:0034447IMP-very-low-density lipoprotein particle clearance9649566
GO:0042158IEA-lipoprotein biosynthetic process-
GO:0042159IBA-lipoprotein catabolic process-
GO:0042311IEA-vasodilation-
GO:0042632IDA-cholesterol homeostasis9649566
GO:0042982IDA-amyloid precursor protein metabolic process21593558
GO:0043407IDA-negative regulation of MAP kinase activity9685360
GO:0043524IBA-negative regulation of neuron apoptotic process-
GO:0043537IDA-negative regulation of blood vessel endothelial cell migration9685360
GO:0043687TAS-post-translational protein modification-
GO:0043691IDA-reverse cholesterol transport8127890
GO:0044267TAS-cellular protein metabolic process-
GO:0044794IMP-positive regulation by host of viral process25122793
GO:0045541IDA-negative regulation of cholesterol biosynthetic process1917954
GO:0045807IDA-positive regulation of endocytosis7683668
GO:0046889IDA-positive regulation of lipid biosynthetic process12042316
GO:0046907TAS-intracellular transport9622609
GO:0048168TAS-regulation of neuronal synaptic plasticity9622609
GO:0048844IEA-artery morphogenesis-
GO:0050728IC-negative regulation of inflammatory response8995232
GO:0051000IDA-positive regulation of nitric-oxide synthase activity8995232
GO:0051044IDA-positive regulation of membrane protein ectodomain proteolysis15950758
GO:0051651IEA-maintenance of location in cell-
GO:0055089IDA-fatty acid homeostasis24345162
GO:0060999IDA-positive regulation of dendritic spine development24328732
GO:0070328ISS-triglyceride homeostasis-
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway16805831
GO:0090090IGI-negative regulation of canonical Wnt signaling pathway16805831
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway22988876
GO:0090209IEA-negative regulation of triglyceride metabolic process-
GO:0097113IDA-AMPA glutamate receptor clustering24328732
GO:0097114IDA-NMDA glutamate receptor clustering24328732
GO:0098869IEA-cellular oxidant detoxification-
GO:1900221IDA-regulation of amyloid-beta clearance24446231
GO:1900272IDA-negative regulation of long-term synaptic potentiation16273551
GO:1901215IDA-negative regulation of neuron death24259049
GO:1901628IDA-positive regulation of postsynaptic membrane organization24259049
GO:1901630IDA-negative regulation of presynaptic membrane organization24259049
GO:1902430IDA-negative regulation of amyloid-beta formation24154541
GO:1902952IDA-positive regulation of dendritic spine maintenance24328732
GO:1902995IDA-positive regulation of phospholipid efflux12042316
GO:1903002IDA-positive regulation of lipid transport across blood brain barrier24345162
GO:1905855IDA-positive regulation of heparan sulfate binding7683668
GO:1905860IDA-positive regulation of heparan sulfate proteoglycan binding8300609
GO:1905890IDA-regulation of cellular response to very-low-density lipoprotein particle stimulus7592957
GO:1905908TAS-positive regulation of amyloid fibril formation9228033
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
APOEA2M1065249831625 Affinity Capture-Western; Reconstituted Complex
APOEA2M1068459831625 Affinity Capture-Western; Reconstituted Complex
LRP2APOE1102167768901 Reconstituted Complex
LRP2APOE1068457768901 Reconstituted Complex
MAPTAPOE1103088620924 Reconstituted Complex
MAPTAPOE1068458620924 Reconstituted Complex
NEFMAPOE1108188620924 Reconstituted Complex
NEFMAPOE1068458620924 Reconstituted Complex
UBCAPOE11316411401504 Affinity Capture-Western
UBCAPOE10684511401504 Affinity Capture-Western
PLTPAPOE10684512810820 Affinity Capture-Western
PLTPAPOE11137412810820 Affinity Capture-Western
LRP8APOE10684512950167 Reconstituted Complex
LRP8APOE11357912950167 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APOEAPOE_GWAS, APOE_ME.1, rs1081105, rs1081106, rs405509, rs429358, rs439401, rs440446, rs449647, rs7412, rs769446, rs769448, rs769449, rs769450 Gene overview in AlzGene
APOE_e2/3/4APOE_e2/3/4 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
APOEapoe_e2/3/4, rs405509, rs429358, rs449647, rs7412 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
APOEAPOE_e2/3/4, rs10119, rs405509, rs440446, rs449647, rs741780 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88057
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010724-18'