AutismKB 2.0

Annotation Details for APP


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Basic Information Top
Gene Symbol:APP ( AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN2 )
Gene Full Name: amyloid beta (A4) precursor protein
Band: 21q21.3
Quick LinksEntrez ID:351; OMIM: 104760; Uniprot ID:A4_HUMAN; ENSEMBL ID: ENSG00000142192; HGNC ID: 620
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space16502470
GO:0005641IDA-nuclear envelope lumen21989385
GO:0005737IDA-cytoplasm18509662
GO:0005737ISS-cytoplasm-
GO:0005768IDA-endosome18353773
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005790IEA-smooth endoplasmic reticulum-
GO:0005791IEA-rough endoplasmic reticulum-
GO:0005794IDA-Golgi apparatus20427278
GO:0005794ISS-Golgi apparatus-
GO:0005796TAS-Golgi lumen-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane12805363
GO:0005887TAS-integral component of plasma membrane10806211
GO:0005905IEA-clathrin-coated pit-
GO:0005911IEA-cell-cell junction-
GO:0009986IDA-cell surface7593229
GO:0016021ISS-integral component of membrane-
GO:0030134IEA-ER to Golgi transport vesicle-
GO:0030424ISS-axon-
GO:0031093TAS-platelet alpha granule lumen-
GO:0031594IEA-neuromuscular junction-
GO:0031904TAS-endosome lumen-
GO:0032588TAS-trans-Golgi network membrane-
GO:0035253IEA-ciliary rootlet-
GO:0043195IEA-terminal bouton-
GO:0043197IDA-dendritic spine11988176
GO:0043198IDA-dendritic shaft11988176
GO:0043235IDA-receptor complex23382219
GO:0044304IEA-main axon-
GO:0045121IDA-membrane raft24499793
GO:0045177IEA-apical part of cell-
GO:0045202IDA-synapse11988176
GO:0048471IDA-perinuclear region of cytoplasm20427278
GO:0051233IEA-spindle midzone-
GO:0070062IDA-extracellular exosome19199708
GO:0097449IEA-astrocyte projection-
GO:1990761IEA-growth cone lamellipodium-
GO:1990812IEA-growth cone filopodium-
GO ID Evidence Qualifier GO_term References
GO:0003677ISS-DNA binding-
GO:0004867IDA-serine-type endopeptidase inhibitor activity10652580
GO:0005102IPI-receptor binding19849849
GO:0005515IPI-protein binding2119582
GO:0008201IEA-heparin binding-
GO:0016504IEA-peptidase activator activity-
GO:0019899IPI-enzyme binding24499793
GO:0042802IPI-identical protein binding16286452
GO:0046914IEA-transition metal ion binding-
GO:0051425IPI-PTB domain binding12805363
GO:0070851IEA-growth factor receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0001934IDA-positive regulation of protein phosphorylation11404397
GO:0001967IEA-suckling behavior-
GO:0002265IGI-astrocyte activation involved in immune response23152628
GO:0002576TAS-platelet degranulation-
GO:0006378ISS-mRNA polyadenylation-
GO:0006417ISS-regulation of translation-
GO:0006468ISS-protein phosphorylation-
GO:0006878ISS-cellular copper ion homeostasis-
GO:0006897ISS-endocytosis-
GO:0006979IEA-response to oxidative stress-
GO:0007155IEA-cell adhesion-
GO:0007176ISS-regulation of epidermal growth factor-activated receptor activity-
GO:0007219IEA-Notch signaling pathway-
GO:0007409ISS-axonogenesis-
GO:0007611IGI-learning or memory19587288
GO:0007617ISS-mating behavior-
GO:0007626ISS-locomotory behavior-
GO:0008088ISS-axo-dendritic transport-
GO:0008203IEA-cholesterol metabolic process-
GO:0008285IDA-negative regulation of cell proliferation22944668
GO:0008344ISS-adult locomotory behavior-
GO:0008542ISS-visual learning-
GO:0009987IMP-cellular process25620700
GO:0010288IEA-response to lead ion-
GO:0010628IMP-positive regulation of gene expression23164821
GO:0010951IEA-negative regulation of endopeptidase activity-
GO:0010952IEA-positive regulation of peptidase activity-
GO:0010971IEA-positive regulation of G2/M transition of mitotic cell cycle-
GO:0016199ISS-axon midline choice point recognition-
GO:0016322ISS-neuron remodeling-
GO:0016358ISS-dendrite development-
GO:0030198ISS-extracellular matrix organization-
GO:0030198TAS-extracellular matrix organization-
GO:0030900IEA-forebrain development-
GO:0031175ISS-neuron projection development-
GO:0035235ISS-ionotropic glutamate receptor signaling pathway-
GO:0040014ISS-regulation of multicellular organism growth-
GO:0043393IEA-regulation of protein binding-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0045087TAS-innate immune response-
GO:0045665IEA-negative regulation of neuron differentiation-
GO:0045931ISS-positive regulation of mitotic cell cycle-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048167IGI-regulation of synaptic plasticity21113149
GO:0048669ISS-collateral sprouting in absence of injury-
GO:0050803ISS-regulation of synapse structure or activity-
GO:0050808IGI-synapse organization19587288
GO:0050885IEA-neuromuscular process controlling balance-
GO:0051124IEA-synaptic growth at neuromuscular junction-
GO:0051247IMP-positive regulation of protein metabolic process11404397
GO:0051247ISS-positive regulation of protein metabolic process-
GO:0051402IMP-neuron apoptotic process19225519
GO:0051563IEA-smooth endoplasmic reticulum calcium ion homeostasis-
GO:0071320IEA-cellular response to cAMP-
GO:0071874IEA-cellular response to norepinephrine stimulus-
GO:0090647TAS-modulation of age-related behavioral decline25390368
GO:0098815IGI-modulation of excitatory postsynaptic potential20974225
GO:1900273IGI-positive regulation of long-term synaptic potentiation20974225
GO:1904646IGI-cellular response to amyloid-beta23152628
GO:1990000IMP-amyloid fibril formation25620700
GO:1990090IEA-cellular response to nerve growth factor stimulus-
GO:2000310TAS-regulation of NMDA receptor activity17360908
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
APPACHE10656112427014 Reconstituted Complex
APPACHE10684812427014 Reconstituted Complex
APPAPBA11068178887653 12196555 Affinity Capture-Western; Reconstituted Complex
APPAPBA11068488887653 12196555 Affinity Capture-Western; Reconstituted Complex
APPAPBA21068189890987 12196555 12972431 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APPAPBA21068489890987 12196555 12972431 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APPAPBB11068198855266 8887653 9045663 9837937 10081969 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APPAPBB11068488855266 8887653 9045663 9837937 10081969 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APPAPBB210684814527950 Affinity Capture-Western
APPAPBB210682014527950 Affinity Capture-Western
BGNAPP1071027793988 Reconstituted Complex
BGNAPP1068487793988 Reconstituted Complex
NAE1APP1068488626687 Affinity Capture-Western; Reconstituted Complex
NAE1APP1144028626687 Affinity Capture-Western; Reconstituted Complex
SNCBAPP1068489163350 Reconstituted Complex
SNCBAPP1125049163350 Reconstituted Complex
SNCAAPP1068489163350 Reconstituted Complex
SNCAAPP1125069163350 Reconstituted Complex
HSD17B10APP1068489338779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HSD17B10APP1092789338779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CAV1APP1068489553108 Co-fractionation; Protein-RNA
CAV1APP1073059553108 Co-fractionation; Protein-RNA
APPBP2APP1068489843960 Reconstituted Complex; Two-hybrid
APPBP2APP1157699843960 Reconstituted Complex; Two-hybrid
APBA3APP10684810049767 12196555 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APBA3APP11492010049767 12196555 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APBB3APP10684810081969 Reconstituted Complex
APBB3APP11559310081969 Reconstituted Complex
GSNAPP10684810329371 Affinity Capture-Western; Reconstituted Complex
GSNAPP10918910329371 Affinity Capture-Western; Reconstituted Complex
DAB1APP10797010460257 Reconstituted Complex
DAB1APP10684810460257 Reconstituted Complex
BLMHAPP10684810973933 Co-fractionation; Reconstituted Complex
BLMHAPP10711110973933 Co-fractionation; Reconstituted Complex
NCSTNAPP10684810993067 Affinity Capture-Western
NCSTNAPP11696110993067 Affinity Capture-Western
KLC1APP10684811144355 Reconstituted Complex
KLC1APP11002911144355 Reconstituted Complex
FBLN1APP10684811238726 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBLN1APP10848611238726 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DAB2APP10684811247302 Reconstituted Complex
DAB2APP10797111247302 Reconstituted Complex
CALRAPP10684811378243 Affinity Capture-Western
CALRAPP10726211378243 Affinity Capture-Western
SHC1APP10684811877420 Affinity Capture-Western; Reconstituted Complex
SHC1APP11236111877420 Affinity Capture-Western; Reconstituted Complex
COL25A1APP10684811927537 Co-localization; Reconstituted Complex
COL25A1APP12414311927537 Co-localization; Reconstituted Complex
CLSTN1APP10684812972431 15037614 Affinity Capture-Western
CLSTN1APP11655012972431 15037614 Affinity Capture-Western
SETAPP10684816162853 Protein-peptide
SETAPP11231616162853 Protein-peptide
HGSAPP10684819019082 Reconstituted Complex
HGSAPP11459319019082 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
APPAPP_-9C/G, APP_VNTR7i, rs104173126, rs1191028526, rs11911934, rs178302626, rs187606426, rs200098926, rs202622526, rs205117426, rs207065526, rs21448826, rs215607926, rs21677326, rs221177326, rs223498826, rs224268326, rs224611526, rs282996626, rs282996826, rs282998426, rs283001226, rs283002126, rs283002526, rs283002926, rs283003026, rs283003626, rs283003826, rs283004126, rs283004526, rs283004626, rs283005026, rs283005226, rs283005326, rs283005426, rs283005626, rs283008826, rs283010326, rs364048, rs36404826, rs364051, rs438031, rs43803126, rs44066626, rs45401726, rs459543, rs463946, rs466433, rs466448, rs46644826, rs46660926, rs481709026, rs76247926, rs76803926 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
APPD21S1253 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88059
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000616-13'